Paroxetine for hepatopulmonary syndrome?

Abstract:

:Hepatopulmonary syndrome (HPS) is a severe pulmonary sequela which can affect up to 15% of patients with cirrhotic liver disease. There is no treatment for HPS other than liver transplantation. The cause of HPS is incompletely understood, but the pulmonary vasodilation in HPS is thought to be related to increased levels of nitric oxide. We therefore suggest that, the extremely safe and commonly used antidepressant medication paroxetine (Paxil) which is a potent nitric oxide synthase (NOS) inhibitor be considered for use in HPS.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Altschuler EL,Kast RE

doi

10.1016/j.mehy.2003.10.017

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

446-7

issue

3

eissn

0306-9877

issn

1532-2777

pii

S0306987703003888

journal_volume

62

pub_type

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