Three-dimensional spring model: a new hypothesis of pathogenesis of adolescent idiopathic scoliosis.

abstract：:There have been increasing numbers of reports that anti-osteoporosis drugs cause osteonecrosis. A typical example is medication-related osteonecrosis of the jaws (MRONJ) which can cause massive necrosis and defects of the jaws. Thus, the dosage and effects of anti-osteoporosis drugs should be re-examined. Our hypothes...

journal_title：Medical hypotheses

authors： Xiong Z,Wu J,Liu Z,Jing W

更新日期：2020-01-01 00:00:00

abstract：:p27(Kip1) (here after referred to as p27) is a member of a family of cyclin-dependent kinase inhibitors that control cell cycle. There is a considerable evidence that p27 plays a pivotal role in multiple foundational cellular processes, including cell proliferation, cell differentiation, and apoptosis. A large number ...

journal_title：Medical hypotheses

authors： Guan X,Chen L,Wang J

更新日期：2007-01-01 00:00:00

abstract：:'Electrohypersensitivity' is often explained as a psychological syndrome. Our modern environment contains a lot of different substances and some of them are toxic. Mycotoxins are types of toxins that are biologically very active and that affect living organisms. Mycotoxins and fungi capable of producing toxins have be...

journal_title：Medical hypotheses

authors： Anttila K

更新日期：2000-09-01 00:00:00

abstract：:Ligaments are generally viewed as passive structural elements. Virtually all treatments for torn ligaments are based upon a structural paradigm. However, there is considerable evidence to suggest that ligaments function as neural sensors to facilitate supportive reflex contractions of muscles. It is hypothesized that ...

journal_title：Medical hypotheses

authors： Brand RA

更新日期：1989-08-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a complex and heterogeneous disease characterized by central obesity, impaired glucose metabolism, dyslipidemia, arterial hypertension, insulin resistance and high-sensitivity C-reactive protein. In 2006, a neurotrophic hypothesis of the etiopathogenesis of MetS was launched. This hypothes...

journal_title：Medical hypotheses

authors： Hristova MG

更新日期：2013-10-01 00:00:00

abstract：:Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large numbe...

journal_title：Medical hypotheses

authors： Huang Y,Liu A,Liu L,Wang B,Liang G

更新日期：2020-02-01 00:00:00

abstract：:Curvilinear distraction is currently under investigation to reconstruct curved maxillofacial bone defects. However, previous studies have revealed the discrepancy between the contour of the regenerated bone in the distraction gap and the curvilinear pathway of the transport disc. We hypothesize that the discrepancy is...

journal_title：Medical hypotheses

authors： Zhou L,Shang H,Feng Z,Liu C,Ye W,Ma Q,Wu W,Liu Y

更新日期：2012-10-01 00:00:00

abstract：:This evidence, then, would suggest that the olive becomes active when, with a change in the motor task, the motor performance is required to adjust to the new circumstance. From Smith's experiments on blood pressure, it is extrapolated that the olive becomes active when there is a change in the physiological state, an...

journal_title：Medical hypotheses

authors： Kennedy PR

更新日期：1978-11-01 00:00:00

abstract：:What causes cancer? To date, this question is left with no answer. The scientific community keeps defining cancer as a proliferation of cells in an uncontrolled and uncontrollable manner. The hypothesis developed here through an understanding of the cancer cell's behaviour led to its re-definition, providing answers t...

journal_title：Medical hypotheses

authors： Majerus MA

更新日期：2002-06-01 00:00:00

abstract：:Class II malocclusion is one of the most common orthodontic problems. The main aetiology of Class II malocclusion is mandibular retrognathia. A variety of functional appliances have been used to stimulate mandibular growth in adolescence, however, the effects remain unsatisfactory. Therefore, new approaches are in nee...

journal_title：Medical hypotheses

authors： Li Y,Yang P,Fan X,Wang J,Liu J,Zhao Z,Zhao M

更新日期：2009-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative disease of uncertain etiology. In MS, neurodegeneration is thought to be secondary to autoimmune-mediated damage. However, no cohesive explanation yet exists as to how environmental factors interact to induce a neurodegenerative autoimmune response. Insufficient sunlight ...

journal_title：Medical hypotheses

authors： Hayes CE,Donald Acheson E

更新日期：2008-01-01 00:00:00

abstract：:I hypothesize that the intermediates of the kynurenine (Kyn) pathway (KP) of tryptophan (Trp) degradation kynurenic acid (KA) and quinolinic acid (QA) play opposite roles in inflammatory diseases, with KA being antiinflammatory and QA being immunosuppressant. Darlington et al. have demonstrated a decrease in the ratio...

journal_title：Medical hypotheses

authors： Badawy AA

更新日期：2018-09-01 00:00:00

abstract：:The resonator theory claims that light scattering by the melanin granules of the retinal pigment epithelium causes light to be reflected back through the outer segment of the cones, in a direction opposite that of the incident light. These two opposite directed wave motions may produce standing waves inside the cone o...

journal_title：Medical hypotheses

authors： Bülow N

更新日期：1992-02-01 00:00:00

abstract：:Chronic, tertiary Lyme disease, a vector-borne infection most accurately designated neuroborreliosis, is often misdiagnosed. Infectors of the human brain, Lyme borrelial spirochetes are neurotropic, similar to the spirochetes of syphilis. Symptoms of either disease may be stable and persistent, transient and inconsist...

journal_title：Medical hypotheses

authors： Sherr VT

更新日期：2005-01-01 00:00:00

abstract：:A hypothesis is presented concerning the origin of the action of muscles in the human and animal bodies It is advanced that muscle action originates with very rapid chemical reactions known as percussion reactions. These give rise to the temporary precipitation of solids in muscle cells. The accompanying volume change...

journal_title：Medical hypotheses

authors： Robertson DS

更新日期：2002-08-01 00:00:00

abstract：:The characteristic insoluble, senile (neuritic) plaques found extracellularly in brains of patients with Alzheimer's disease (AD) contain the fibrillar form of beta-amyloid (Abeta42). A substantial proportion of autopsied elderly brains have demonstrated DNA evidence of herpes simplex virus type 1 (HSV-1) infiltration...

journal_title：Medical hypotheses

authors： Kammerman EM,Neumann DM,Ball MJ,Lukiw W,Hill JM

更新日期：2006-01-01 00:00:00

abstract：:One of the most affected cognitive impairments in children who experienced heavy burdens of diarrhea is semantic fluency, the same impairment that is most affected in Alzheimer's dementia. These findings are leading us into provocative genetic studies that may elucidate the evolution of such genetic polymorphisms as t...

journal_title：Medical hypotheses

authors： Oriá RB,Costa CM,Lima AA,Patrick PD,Guerrant RL

更新日期：2009-11-01 00:00:00

abstract：:The globally increasing incidences of Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM) can have a common background. If challenged by the contemporary high level of nutritional glucose stimulation, the β-cells in genetically predisposed individuals are at risk for damage which can lead to the diseases. The fat to car...

journal_title：Medical hypotheses

authors： Sjöblad S

更新日期：2019-04-01 00:00:00

abstract：:Many experimental evidences indicate that infection with Trypanosoma cruzi delays or inhibits the growth of malignant tumors in different strains of mice and in rats. These facts were verified by different workers. Although earlier workers proposed that this effect would be due to a toxin of T. cruzi, most of the accu...

journal_title：Medical hypotheses

authors： Cabral HR

更新日期：2000-01-01 00:00:00

abstract：:Epidemiological findings on the relation between foods and colon cancer are inconsistent. Many, but far from all, found positive associations for meat and fat and negative ones for vegetables and fruits. Explanations so far have focused on direct biochemical conversions in the colon or transit time, but they remain un...

journal_title：Medical hypotheses

authors： Holmqvist OH

更新日期：2000-03-01 00:00:00

abstract：:In the AKR strain of mice a high incidence of spontaneous lymphoid leukemia develops before 12 months of age. Genetic, viral, and endocrine factors interact during development to produce the syndrome. Many of the deficiencies of AKR mice are associated with gene action in chromosome 17, at or near the major histocompa...

journal_title：Medical hypotheses

authors： Vriend J

更新日期：1976-11-01 00:00:00

abstract：:Primary angle closure glaucoma has been called the most common form of glaucoma in the world, and the leading cause of bilateral blindness. Pupillary block is felt to be the main mechanism of outflow obstruction in this condition. Recent advances in morphologic assessment of angle closure, specifically by means of ult...

journal_title：Medical hypotheses

authors： Razeghinejad MR,Kamali-Sarvestani E

更新日期：2007-01-01 00:00:00

abstract：:A hypothetical pathogenesis for a typical case of amyotrophic lateral sclerosis (ALS) follows from opinions of Rowland and results of neuroscientists at Baylor. ALS might typically result from an autoimmune disorder that causes IgG to enhance release of acetylcholine (ACh) from axon terminals. Motor neuron overactivit...

journal_title：Medical hypotheses

authors： Brown DW

更新日期：1994-06-01 00:00:00

abstract：:Acute viral infection is characterised by high-level replication before prompt decline of viraemia and, commonly, viral clearance. This kinetic pattern is generally held to be due to immune control. However, infection with some viruses, notably hepatitis C (HCV), hepatitis B (HBV) and the human immunodeficiency virus ...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：2004-01-01 00:00:00

abstract：:The reluctance of physicians to get involved with child abuse can be attributed to the problem of role conflict. Physicians derive their social authority from the Aesculapian tradition. This form of social authority is fragile and easily subverted, yet of utmost importance if physicians are to retain their effectivene...

journal_title：Medical hypotheses

authors： Thong YH

更新日期：1982-04-01 00:00:00

abstract：:Physical inactivity and a low maximal aerobic capacity (VO2max) strongly predict morbidity and mortality in patients with type 2 diabetes (T2D). Patients with T2D have a reduced VO2max when compared with healthy individuals of similar age, weight, and physical activity levels, and this lower aerobic capacity is usuall...

journal_title：Medical hypotheses

authors： Leone RJ,Lalande S

更新日期：2017-03-01 00:00:00

abstract：:We develop here the hypothesis that polycystic kidneys (PCK) may maintain, to a certain extent, the ability to perform endocrine functions. We know that patients with adult polycystic kidney disease (APCKD) produce more erythropoietin and maintain a higher hematocrit than patients with other primary diseases of the ki...

journal_title：Medical hypotheses

authors： Rotellar C,Gelfand MC

更新日期：1989-09-01 00:00:00

abstract：:The mechanisms of fibroproliferation disease (FPD) of the skin, such as keloids and hypertrophic scars, are still unknown. Since mechanical stress appears to be an important factor for FPD generation, we have studied the intervening factors that connect mechanical stress with keloid and scar formation. Hence, we intro...

journal_title：Medical hypotheses

authors： Akaishi S,Ogawa R,Hyakusoku H

更新日期：2008-01-01 00:00:00

abstract：:The psychological attributes of intelligence and personality are usually seen as being quite distinct in nature: higher intelligence being regarded a 'gift' (bestowed mostly by heredity); while personality or 'character' is morally evaluated by others, on the assumption that it is mostly a consequence of choice? So a ...

journal_title：Medical hypotheses

authors： Charlton BG

更新日期：2009-10-01 00:00:00

abstract：:Structures which morphologically resemble treponemes have been found in material from patients suffering from latent or late latent syphilis, many of whom have received treatment in the past. These structures were also found in the blood or spinal fluid (SF) of asymptomatic patients with both positive and negative ser...

journal_title：Medical hypotheses

authors： Ghinsberg RC,Nitzan Y

更新日期：1992-09-01 00:00:00