Abstract：
:There are many observations regarding the behaviour of melanoma which points away from sunshine as the main cause of this tumour. Incidence data shows that the increase is mostly seen for thin melanomas which cannot be attributed to sun exposure but increasing screening over the last 20 years. Melanoma behaves in a similar fashion all over the world regarding age of onset, gender differences and histological subtypes. An excess of naevi is the strongest risk factor for melanoma and their appearance and involution throughout life, and the differences in naevus distribution according to gender is giving us a lot of clues about melanoma biology. Melanoma like all cancers is a complex disease with the involvement of many common and low penetrance genes many of them involved in pigmentation and naevogenesis but these only explain a very small portion of melanoma susceptibility. Genes involved in melanocyte differentiation early on in embryogenesis are also becoming relevant for melanoma initiation and progression. Reduced senescence and longevity as well as body weight and energy expenditure are also relevant for melanoma susceptibility. These observations with links between melanoma and non-sun related phenotypes as well as gene discoveries should help to assess the relative contribution of genetic and environmental factors in its causation.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Bataille Vdoi
10.1016/j.mehy.2013.05.031subject
Has Abstractpub_date
2013-11-01 00:00:00pages
846-50issue
5eissn
0306-9877issn
1532-2777pii
S0306-9877(13)00272-7journal_volume
81pub_type
杂志文章,评审abstract：:The paradigm of an immune system presumes that a system arose specifically to combat infection -- hence its name. This paradigm gained credibility with the discovery of antibodies and anamnestic immunity, even though these are relatively late arrivals in evolution. Another presumption has been that thymus-dependent T ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0645
更新日期：1999-03-01 00:00:00
abstract：:Reconciling the early promising results of radiation therapy in the treatment of epilepsy with the recent theory concerning the role of nonsynaptic mechanisms in focal epileptogenesis, it is suggested that the potential of irradiation as an alternative to temporal lobe resection in intractable epilepsy should be re-ev...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(80)90102-4
更新日期：1980-05-01 00:00:00
abstract：:Keratoacanthomas have many characteristics of squamous cell carcinoma and in the past were interpreted as squamous cell carcinomas. It is now known that these lesions spontaneously resolve if left untreated. In man the lesions occur on sunlight damaged areas or areas exposed to tar. Many of the experimental cancers of...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(88)90063-1
更新日期：1988-06-01 00:00:00
abstract：:The possibility of a pathway, common to progression, in entities in which activated macrophages or microglia are present, amenable to particular therapies, is discussed. Immunoglobulin synthesis and activation of the complement pathway may be critical elements in progression. It is possible progression in a proportion...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.06.001
更新日期：2006-01-01 00:00:00
abstract：:Cancer is a tissue that requires a genetic program, possibly involving hundreds of genes, as indicated by studies of differential gene expression performed with microarrays in various types of cancer. Cancer is thus a biological process of considerable precision as described by Schrödinger's equation, and it is not si...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.11.033
更新日期：2009-04-01 00:00:00
abstract：:Oral water irrigation devices (WIDs) are widely used for oral physiotherapy in homes and dental clinics throughout the world. A major area of concern in the use of WIDs has been the possibility of injury to the sulcular epithelium and underlying tissue. There are several documented clinical cases of tissue injury with...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(85)90110-0
更新日期：1985-12-01 00:00:00
abstract：:It has been previously proposed that conscious process involves the collapse of quantum, dynamical brain states through conscious observation. It has been further proposed that the brain process has an active role in selecting the status of uncertain stimuli. On the basis of these proposals it was predicted that event...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.10.002
更新日期：2004-01-01 00:00:00
abstract：UNLABELLED:CRPS is an acute pain disease expressed as chronic pain with a severe loss of tissue and function. CRPS usually occurs after minor injuries and then progresses in a way that is scarcely controllable, or completely uncontrollable. This article addresses the functional control mechanism of a biological organis...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.07.017
更新日期：2015-11-01 00:00:00
abstract：:The measurement of urinary neopterin and biopterin may be an important non-specific diagnostic tool. Urinary biopterin has been found to be decreased in parkinsonian patients, and in hyperphenylalanemia as a variant of phenylketonuria. Urinary neopterin has been found to be elevated in numerous conditions. It has been...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(89)90105-9
更新日期：1989-08-01 00:00:00
abstract：:Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment. ...
journal_title：Medical hypotheses
pub_type： 信件
doi：10.1016/j.mehy.2020.110202
更新日期：2020-11-01 00:00:00
abstract：:The ability of tumor cells to differentiate in combination with their ability to express genes that are not expressed in normal tissues, may result in the emergence of new cell types in evolution. Tumors may play an evolutionary role by providing conditions (space and resources) for the expression of newly evolving ge...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.07.027
更新日期：2010-01-01 00:00:00
abstract：:The authors present an extended version of Clark's and Ariëns's classical theory that enables the interpretation and quantitative characterization of dose-response curves which are not in accordance with classical theory. Being supported by the chemical receptor theory, the new model expands its applicability to two o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(85)90063-5
更新日期：1985-04-01 00:00:00
abstract：:Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic disease in adults, and it is thought to be increasing in incidence. FSGS is often difficult to treat and even has a high propensity to relapse after transplant. Indeed, this suggests that there might be some circulating factor responsible for pro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1438
更新日期：2001-12-01 00:00:00
abstract：:This paper discusses a mechanism for converting heterochromatin into the more relaxed state of euchromatin. Actuation of such state conversion stems from disassembly of internal vesicles that are incapable of surviving when trapped within the inner chamber of mammalian nuclei. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00233-5
更新日期：2002-11-01 00:00:00
abstract：:Natural whole foods contain fats as structural components, and have a balance of polyunsaturated fat, monounsaturated fat, and saturated fat. Since we are still a Paleolithic species, adapted to eating only wild foods, it is difficult to justify the consumption of anything other than an overall balance of triglyceride...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90210-3
更新日期：1997-09-01 00:00:00
abstract：:Natural objects, live and inanimate, actively maintain their entities by using their capacities (i.e., properties, internal resources, mechanisms, and experience) adequately to their needs. It is suggested that the principle of adequate function is a law of nature. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90078-2
更新日期：1986-03-01 00:00:00
abstract：:Immunoreactive prolactin in high concentration was detected in the human semen. Therefore, the effect of prolactin on the various metabolic parameters of the human spermatozoa was studied. It was found that prolactin brought about many of the biochemical changes in the spermatozoa which are known to be associated with...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(79)90079-3
更新日期：1979-08-01 00:00:00
abstract：:Hypotheses regarding the factors that predispose individuals to developing AIDS after exposure to HTLV-III/LAV are beginning to emerge. It is suggested here that surgical removal of tonsils in childhood may increase the risk of developing opportunistic infections after infection with this newly discovered retrovirus. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90076-9
更新日期：1986-03-01 00:00:00
abstract：:The present study developed a feature selection (FS)-based decision support system using the electroencephalography (EEG) signals recorded from neonates with and without seizures. The study employed 10 different FS algorithms to reduce the classification cost by using fewer features and to improve the classification p...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109464
更新日期：2020-02-01 00:00:00
abstract：:Over the past decade evidence from multiple research trajectories have converged to provide evidence that impaired glucose metabolism and mitochondrial dysfunction in the brain are the critical issues laying at the root of Bipolar Disorder (BD). These developments have been paralleled by increasing recognition of the ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110299
更新日期：2020-12-01 00:00:00
abstract：:An unacceptably high incidence of preterm labour is seen in the black and coloured communities of South Africa. This hypothesis proposes that sodium-potassium adenosine triphosphatase activity plays an important role in preterm labour. The impaired activity of the sodium pump leads to increased cytosolic calcium level...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90081-x
更新日期：1996-09-01 00:00:00
abstract：:In mathematics and physics, chaos theory deals with the behavior of certain nonlinear dynamical systems that under certain conditions exhibit a phenomenon known as chaos, which is characterised by a sensitivity to initial conditions. Mathematicians paradoxically call such states of order chaos and distinguish them fro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.02.032
更新日期：2006-01-01 00:00:00
abstract：:A search for control mechanisms involving embryonic genes is explored reviewing a variety of subject areas including, a) the methylation status of DNA and the globin gene, b) ethionine and steroid effects on expression of embryonic genes, c) alpha-fetoprotein gene activity induced by carcinogens and in hepatomas. Also...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90008-e
更新日期：1993-05-01 00:00:00
abstract：:Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.01.026
更新日期：2005-01-01 00:00:00
abstract：:Oral administration of L-arginine in pharmacological doses induces growth hormone and insulin-like growth factor-I responses and stimulates nitric oxide synthesis. Growth hormone and insulin-like growth factor-I are important mediators of bone turnover and osteoblastic bone formation, while nitric oxide is a potent in...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90113-9
更新日期：1994-11-01 00:00:00
abstract：:Several disorders or abnormalities observed in medicine and psychology are not explicable (or not fully explicable) by genetics and environmental influences, either alone or together. These include phobias and philias observed in early infancy, unusual play in childhood, homosexuality, gender identity disorder, a chil...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0920
更新日期：2000-04-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disease and oligodendrocyte degeneration and white matter damage play a critical role in the pathogenesis of AD. FGF/FGF receptor signaling have been implicated in diverse cellular processes including cell apoptosis, survival, adhesion, migration, different...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.12.008
更新日期：2013-04-01 00:00:00
abstract：:Exocytosis and endocytosis are the way of macromolecules transmembrane transport. Pulmonary surfactant (PS), one of such macromolecules, is secreted via exocytosis of lamellar bodies and recycled via endocytosis by type II alveolar epithelial cells (AEC II). It maintains low alveolar surface tension and is therefore e...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.09.012
更新日期：2009-02-01 00:00:00
abstract：:The accumulation of fibrin/fibrinogen and other coagulation factors in and around solid tumors and metastatic foci has been recognized for a century as an aspect of cancer pathology. On this basis, anticoagulants and fibrinolytic agents have been deployed as adjuvant anticancer therapies, but they have proved clinical...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.06.045
更新日期：2007-01-01 00:00:00
abstract：:Most of the evidence of formation of amblyopia is derived traditionally from electrophysiological studies. Recently, there have been many discoveries from genetics, histopathology, biochemistry, immunology and interventional studies. On the basis of evidence gathered in the last five years, the various types of amblyo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90275-9
更新日期：1997-02-01 00:00:00
