An extended hypothetical theory of the dose-response relations in pharmacology.

abstract：:The various neurotransmitter systems postulated to be involved in the pathogenesis of Gilles de la Tourette syndrome(GTS) are described with special reference to the endogenous opioid system(EOS). Malfunction of the opioid system is proposed as the underlying disturbance in this disease causing secondary dysfunction o...

journal_title：Medical hypotheses

authors： Gillman MA,Sandyk R

更新日期：1986-04-01 00:00:00

abstract：:Reflux of biliary secretions into the pancreatic duct following gallstone obstruction of the common biliary pancreatic ampulla has been implicated as a cause of acute pancreatitis. However, the pancreatic duct pressure is higher than the biliary pressure and, therefore, the simple obstruction of the choledochoduodenal...

journal_title：Medical hypotheses

authors： Arendt T,Mönig H,Stüber E,Katsoulis S,Fölsch UR

更新日期：2000-04-01 00:00:00

abstract：:Body size and body composition have been suggested as the best explanation for the temporal trend toward early menarche over the last 100 years. There is evidence from human and animal studies that indicates that body size is not the primary factor in influencing the occurrence of menarche. The data actually show that...

journal_title：Medical hypotheses

authors： Sanchez A,Kissinger DG,Phillips RI

更新日期：1981-11-01 00:00:00

abstract：:Complex spinal reconstructive procedures are invariably associated with excessive intraoperative blood loss that significantly increases the risk of severe perioperative complications. In some cases, excessive hemorrhage is equivalent to estimated total blood volume. Unfortunately, widely exposed bony surfaces are not...

journal_title：Medical hypotheses

authors： Block JE

更新日期：2005-01-01 00:00:00

abstract：:Malignant hyperthermia (MH) is a rare myopathy inducing severe accident when carriers are exposed to triggering agents. MH susceptibility (MHS) is assessed by pharmacological tests performed on muscle strips. Exertional heat stroke (EHS) is a severe accident occurring during long and strenuous exercise. It has been ob...

journal_title：Medical hypotheses

authors： Bourdon L,Canini F

更新日期：1995-09-01 00:00:00

abstract：:The resonator theory claims that light scattering by the melanin granules of the retinal pigment epithelium causes light to be reflected back through the outer segment of the cones, in a direction opposite that of the incident light. These two opposite directed wave motions may produce standing waves inside the cone o...

journal_title：Medical hypotheses

authors： Bülow N

更新日期：1992-02-01 00:00:00

abstract：:Cannabis use has often been associated with various forms of psychosis. Today it is well established that everyone produces marijuana-like compounds known as endocannabinoids. The endocannabinoid system is a homeostatic regulator of all body systems including the nervous system. As a result, imbalances in the endocann...

journal_title：Medical hypotheses

authors： Melamede R

更新日期：2009-02-01 00:00:00

abstract：:In a recent issue of Medical Hypotheses, Dr H L Newbold repeats the assertion that the cause of James B Duke's death in 1925 was pernicious anemia. Dr Newbold postulates that Mr Duke was neurologically impaired as a result of vitamin B-12 deficiency and that he suffered from depression. In an attempt to relieve this d...

journal_title：Medical hypotheses

authors： Halperin EC

更新日期：1991-11-01 00:00:00

abstract：:Silicone may, like any other adjuvant, induce an inflammatory reaction and diseases. There is no data about its use in renal transplant recipients. Increased immunogenicity of silicon may manifest by activation of both the innate and the adaptive immune system cells what promotes a chronic pro-inflammatory response. D...

journal_title：Medical hypotheses

authors： Basic-Jukic N,Ratkovic M,Radunovic D,Kastelan Z

更新日期：2019-02-01 00:00:00

abstract：:Insulin resistance has been associated with people diagnosed with depression. Conversely, it has also been documented that diabetics have an increased risk of depression. Evidence suggests that insulin activity plays a role in serotonergic activity by increasing the influx of tryptophan into the brain. This increased ...

journal_title：Medical hypotheses

authors： Salazar MR

更新日期：2000-12-01 00:00:00

abstract：:There is no secret that despite the rapid development of new methods of cancer therapy, we still are not able to completely destroy the tumor. Every time we attack the tumor, the tumor neutralizes our attempts. Carcinogenesis can be presented as a tree whose branches are different pro-tumor mechanisms and whose trunk ...

journal_title：Medical hypotheses

authors： Malyshev IY,Kuznetsova LV,Mardente S

更新日期：2020-04-01 00:00:00

abstract：:Inflammation and the genes, molecules, and biological pathways that lead to inflammatory processes influence many important and disparate biological processes and disease states that are quite often not generally considered classical inflammatory or autoimmune disorders. These include development, reproduction, aging,...

journal_title：Medical hypotheses

authors： Becker KG

更新日期：2007-01-01 00:00:00

abstract：:Hypotheses regarding the factors that predispose individuals to developing AIDS after exposure to HTLV-III/LAV are beginning to emerge. It is suggested here that surgical removal of tonsils in childhood may increase the risk of developing opportunistic infections after infection with this newly discovered retrovirus. ...

journal_title：Medical hypotheses

authors： McCombie SC

更新日期：1986-03-01 00:00:00

abstract：:Autism may be a disorder linked to the disruption of the G-alpha protein, affecting retinoid receptors in the brain. A study of 60 autistic children suggests that autism may be caused by inserting a G-alpha protein defect, the pertussis toxin found in the DPT vaccine, into genetically at-risk children. This toxin sepa...

journal_title：Medical hypotheses

authors： Megson MN

更新日期：2000-06-01 00:00:00

abstract：:Cancer and other diseases may be a natural biological event, the activities of which may be dependent on the constitution of the individual. Where fetal and embryonic cells are not diseased or faulty or defective, they may be useful as therapies against cancer and other diseases. ...

journal_title：Medical hypotheses

authors： Caesar G

更新日期：2002-05-01 00:00:00

abstract：:We argue that our common diseases should not necessarily be taken as a sign of physiological error. Regulatory networks developed by evolutionary forces to support reproductive fitness happen to include disease as a side-effect. For example, inflammatory and autoimmune diseases are secondary to a strong defence agains...

journal_title：Medical hypotheses

authors： Bredberg A,Lavasani S

更新日期：2013-10-01 00:00:00

abstract：:In this paper I hypothesize that a woman through her vagina absorbs sufficient quantities of the prostaglandins from her partner's semen, to affect her mood. The vagina appears to have an active transport mechanism which readily absorbs the hormones found in seminal plasma. The seminal secretions include estrogens, F....

journal_title：Medical hypotheses

authors： Ney PG

更新日期：1986-06-01 00:00:00

abstract：:The efficiency of anti-tumour drug strongly depends on its dose. Higher drug doses and exposure times usually result in better treatment. It is why the implementation of high-dose treatment is always attractive. However, most of the drug delivery techniques meet essential limitations. In isolated regional perfusion a ...

journal_title：Medical hypotheses

authors： Rukhlenko OS,Guria GT,Vorobiev AI

更新日期：2017-07-01 00:00:00

abstract：:Oesophageal carcinoma is a devastating disease with a poor prognosis. This hypothesis shows how prostaglandin E2 exerts carcinogenic effects in the oesophagus. The contribution of prostaglandin E2 is related to other factors that predispose to oesophageal carcinoma. The implication of the hypothesis is that nonsteroid...

journal_title：Medical hypotheses

authors： Morgan G

更新日期：1997-02-01 00:00:00

abstract：:The incidence of breast cancer in women has increased dramatically over the last decade. Epidemiological markers of this increased incidence include: endocrine related phenomena (early menarche, age of first parity and age of menopause); exposure of the breast to X-radiation; and a group of seemingly disparate factors...

journal_title：Medical hypotheses

authors： Morris JJ,Seifter E

更新日期：1992-07-01 00:00:00

abstract：:A major factor relating to the oversight of neurological dysfunction and seizures caused by magnesium (Mg++) depletion, involves the buffer functions of the skeletal system orchestrated primarily by the parathyroid. A Mg++ depleted subject may appear relatively asymptomatic until a short period after homeostatic respo...

journal_title：Medical hypotheses

authors： Langley WF,Mann DJ

更新日期：1991-01-01 00:00:00

abstract：:Dietary animal fat increases the risk of colorectal cancer. A factor in the increased risk is hypothesised to result from the inhibition of isoforms of a colonic epithelial cell enzyme that detoxifies genotoxins, glutathione S-transferase, by one of the major secondary bile acids produced in the colon by fat digestion...

journal_title：Medical hypotheses

authors： Schneider H

更新日期：1992-10-01 00:00:00

abstract：:Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modificati...

journal_title：Medical hypotheses

authors： Gavin DP,Chase KA,Sharma RP

更新日期：2011-07-01 00:00:00

abstract：:The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...

journal_title：Medical hypotheses

authors： Hässig A,Wen-Xi L,Stampfli K

更新日期：1996-04-01 00:00:00

abstract：:Virulence factors are microbial products that are known to be harmful to the host and may assist in the pathogenesis of the micro-organism. Superantigens, including those produced by bacteria and viruses, clearly act as virulence factors. The clinical effects of superantigens can be not only acute but also chronic and...

journal_title：Medical hypotheses

authors： Soos JM,Schiffenbauer J,Torres BA,Johnson HM

更新日期：1997-03-01 00:00:00

abstract：:Cannabinoid hyperemesis syndrome (CHS), a variant of cyclic vomiting syndrome, is an enigmatic and challenging clinical disorder. As cannabis legalization, use, and potency has increased worldwide over the past decade, so has the prevalence of CHS. These patients often require acute care and inpatient treatment for re...

journal_title：Medical hypotheses

authors： Richards JR

更新日期：2017-06-01 00:00:00

abstract：:In normal and hypertensive subjects, many stimuli which increase ACTH secretion also increase blood pressure and conversely, many drugs which decrease ACTH secretion also decrease blood pressure. We postulate that the hypothalamopituitary adrenal axis plays a role in blood pressure regulation in normal and hypertensiv...

journal_title：Medical hypotheses

authors： Whitworth JA,McLachlan-Troup N,Scoggins BA

更新日期：1987-07-01 00:00:00

abstract：:Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...

journal_title：Medical hypotheses

authors： Di Guardo G

更新日期：1989-07-01 00:00:00

abstract：:Axillary hair is a highly conserved phenotypical feature in humans, and as such deserves at least consideration of its functional significance. Protection from environmental factors is one of the main functions attributed to hair in furred vertebrates, but is believed to be inapplicable to humans. I considered the hyp...

journal_title：Medical hypotheses

authors： Komarova SV

更新日期：2006-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...

journal_title：Medical hypotheses

authors： Jucevičiūtė N,Banaitytė I,Vaitkus A,Balnytė R

更新日期：2019-06-01 00:00:00