Abstract:
:The efficiency of anti-tumour drug strongly depends on its dose. Higher drug doses and exposure times usually result in better treatment. It is why the implementation of high-dose treatment is always attractive. However, most of the drug delivery techniques meet essential limitations. In isolated regional perfusion a tumour can be exposed to high-dose therapeutic influence but the target organ may be isolated from the rest of circulatory system only for a relatively short period of time. During systemic injection of anti-tumour agents dose limitations are dictated by side toxicity danger. Viperidae venoms are known to cause local stagnation of blood flow and blood-tissue exchange processes in the place of snakebite. In present paper we suggest to use Viperidae snake venoms in addition to anti-tumour drugs for regional anti-cancer therapy. We suppose that Viperidae venoms will assist in drug localization. We state that their usage will help in high-dosage therapy implementation.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Rukhlenko OS,Guria GT,Vorobiev AIdoi
10.1016/j.mehy.2017.05.025subject
Has Abstractpub_date
2017-07-01 00:00:00pages
89-92eissn
0306-9877issn
1532-2777pii
S0306-9877(16)30662-4journal_volume
104pub_type
杂志文章abstract::Neandertals were an anatomically distinct hominoid species inhabiting a vast geographical area ranging from Portugal to western Siberia and from northern Europe to the Middle East. The species became extinct 28,000 years ago, coinciding with the arrival of anatomically modern humans (AMHs) in Europe 40,000 years ago. ...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/j.mehy.2010.01.048
更新日期:2010-07-01 00:00:00
abstract::Posttraumatic stress disorder (PTSD) is a severe anxiety disorder that develops after exposure to trauma. Symptoms include persistent reexperiencing, persistent avoidance, persistent numbing, and persistent hyperarousal. Subsequent to trauma exposure, the onset of symptoms of an acute stress reaction can typically dev...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.02.017
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.07.024
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110276
更新日期:2020-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.08.024
更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.10.013
更新日期:2014-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.02.041
更新日期:2019-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(80)90104-8
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abstract::Ampligen, a mismatched double stranded RNA, is hypothesized to be an ideal base therapy for HIV disease to which other agents, such as the nucleoside analogue, AZT, can be advantageously added. The unique properties of Ampligen which support this hypothesis include activation of immune cells, inhibition of virus repli...
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.04.041
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.08.012
更新日期:2014-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90052-3
更新日期:1994-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.021
更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00307-4
更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90123-8
更新日期:1993-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2006.02.017
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.10.010
更新日期:2005-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 信件
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pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.12.050
更新日期:2006-01-01 00:00:00
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更新日期:1998-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.05.011
更新日期:2009-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90127-8
更新日期:1989-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2003.12.021
更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.0740
更新日期:1999-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00013-6
更新日期:2003-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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