Abstract:
:The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with others have recently found that SDH activity, the second step in the polyol pathway, might make a greater contribution to the etiology of diabetic retinopathy than does the first step involving AR. In this paper, we propose a novel hypothesis that polymorphisms of SDH gene may be correlated with SDH gene expression levels in diabetic retinas, thus being a valuable genetic marker for diabetic retinopathy.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Amano S,Yamagishi S,Koda Y,Tsuneoka M,Soejima M,Okamoto T,Inagaki Y,Yamada K,Kimura Hdoi
10.1016/s0306-9877(03)00013-6keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
550-1issue
4eissn
0306-9877issn
1532-2777pii
S0306987703000136journal_volume
60pub_type
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