Abstract:
:The thickness of the choroid is measured on the optical coherence tomography (OCT) as the distance between the hyperreflective retinal pigment epithelium and the hyperreflective chorio-scleral junction, contributed by the choroidal vessels and choroidal melanocytes. Our hypothesis is that the amount of absorption and reflectance of the infrared wavelength OCT light by the melanin present in the choroidal melanocytes contribute to the visibility of the choroidal structures and choroidal thickness on OCT. We explain this hypothesis via two representative cases with choroidal pigmentary abnormalities. In conclusion, we believe that the optical properties of the melanin in choroid influences choroidal measurements and may lead to inaccurate assessment. Therefore, further understanding about choroidal pigmentation is necessary before we further adapt choroidal biomarkers in our clinical practice.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Venkatesh R,Reddy NG,Chhablani Jdoi
10.1016/j.mehy.2020.110408subject
Has Abstractpub_date
2021-01-01 00:00:00pages
110408eissn
0306-9877issn
1532-2777pii
S0306-9877(20)33299-0journal_volume
146pub_type
杂志文章abstract::Several hypotheses have been developed to interpret the progression of tubulointerstitial fibrosis (TF), including senescence, epithelial-mesenchymal transition, inflammation, chronic hypoxia, and reactive oxygen species. All of these hypotheses are based on persistent cell injury and localized cell death. Proliferati...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.01.014
更新日期:2014-06-01 00:00:00
abstract::The Aquatic Ape Theory claims that human ancestors once lived in a semi-aquatic habitat. Some human diseases might be explained by our aquatic past. Such problems include hyperventilation, periodic breathing, laryngo- and bronchospasm, vasomotor rhinopathy, seborrhea, dandruff, male pattern alopecia, rhinophyma, osteo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(87)90076-4
更新日期:1987-11-01 00:00:00
abstract::There are differences in male and female height throughout the growth period. Utilising reference standard height charts we calculated the difference in male and female height as a function of age. A triphasic relationship was observed with statistically significant peaks (males greater than females) at 8 months and 1...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(87)90122-8
更新日期:1984-07-01 00:00:00
abstract::An unexpected and novel finding is described and discussed here concerning the synaptic physiology of hippocampal slices during the period of recovery after brain dissection. Contrary to the common notion that the amplitude of synaptic responses recovers in a single exponential rising fashion, we found that synaptic r...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.09.010
更新日期:2011-12-01 00:00:00
abstract::Body size and body composition have been suggested as the best explanation for the temporal trend toward early menarche over the last 100 years. There is evidence from human and animal studies that indicates that body size is not the primary factor in influencing the occurrence of menarche. The data actually show that...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(81)90124-9
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abstract::Consideration of nine major factors predisposing to cerebral thrombosis, coronary thrombosis or thrombosis in the deep veins of the calf, reveals that these factors all have one thing in common. Estrogen administration, pregnancy, ageing, smoking, infection, trauma, surgery, soft water and winter season are all associ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(79)90072-0
更新日期:1979-08-01 00:00:00
abstract::Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels. The vascular component of the lesion is prone to bleeding and responsible for its clinical "malignancy". Some nasopharyngeal angiofibromas are resistant to surgical therapy because of extensive growth and occasionally bone des...
journal_title:Medical hypotheses
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更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
abstract::In a recent issue of Medical Hypotheses, Dr H L Newbold repeats the assertion that the cause of James B Duke's death in 1925 was pernicious anemia. Dr Newbold postulates that Mr Duke was neurologically impaired as a result of vitamin B-12 deficiency and that he suffered from depression. In an attempt to relieve this d...
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pub_type: 传,历史文章,杂志文章
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更新日期:1991-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.03.027
更新日期:2013-06-01 00:00:00
abstract::Corona virus disease 2019 (Covid-19), a pandemia emerged recently, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). The receptor for corona virus and influenza A is the mucosal cell membrane protein angiotensin converting enzyme 2 (ACE2), which is abundant on the membrane of alveolar cells and ...
journal_title:Medical hypotheses
pub_type: 信件
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更新日期:2020-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(83)90009-9
更新日期:1983-04-01 00:00:00
abstract::The paper studies how certain topologic features of the nuclear envelope may reorganize entrained transcription via spatial rearrangements of genes carried by distinct chromatids. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90202-3
更新日期:1995-07-01 00:00:00
abstract::Invasive carcinoma originates from the epithelial cells lining the lumen of an organ. It is often preceded by metaplasia, dysplasia or carcinoma in situ. The purpose of this review is to suggest that this disease of the epithelium may be, in part, the result of underlying tissue-based disorganization. Human cancer is ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1539
更新日期:2002-04-01 00:00:00
abstract::Since forced unilateral nostril breathing activates the contralateral brain hemisphere, an animal analogue of this technique could be provided by methylmethacrylate gluing large plastic pellets in either the right or left nostrils in a group of rats. A large number of physiological, pharmacological, and immunological ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90047-9
更新日期:1989-03-01 00:00:00
abstract::The authors present an extended version of Clark's and Ariëns's classical theory that enables the interpretation and quantitative characterization of dose-response curves which are not in accordance with classical theory. Being supported by the chemical receptor theory, the new model expands its applicability to two o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90063-5
更新日期:1985-04-01 00:00:00
abstract::Epidemiological findings on the relation between foods and colon cancer are inconsistent. Many, but far from all, found positive associations for meat and fat and negative ones for vegetables and fruits. Explanations so far have focused on direct biochemical conversions in the colon or transit time, but they remain un...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0878
更新日期:2000-03-01 00:00:00
abstract::Mild traumatic brain injury, often referred to as concussion, is a common, potentially debilitating, and costly condition. One of the main challenges in diagnosing and managing concussion is that there is not currently an objective test to determine the presence of a concussion and to guide return-to-play decisions fo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.05.012
更新日期:2015-09-01 00:00:00
abstract::The aim was to search for periodical fluctuations in daily occurrence of gout attacks during the synodic lunar cycle. 126 gout attacks were recorded between 1972 and 1994 at known calendar dates. The synodic plexogram, displaying the number of attacks for each day of the cycle, was processed by cosinor regression. A p...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0973
更新日期:2000-07-01 00:00:00
abstract::Superficial fraying, splitting and fibrillation of articular cartilage as a consequence of ageing or mechanical injury is not always associated with joint pain. However, similar cartilage lesions accompanied by synovitis and engorgement of the subchondral vasculature generally is; the disorder being known as osteoarth...
journal_title:Medical hypotheses
pub_type: 杂志文章
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abstract::P53 is an oncosuppressor protein which acts via transcriptional and non-transcriptional mechanisms. The transcriptional function of p53 is mediated by specific responsive elements (RE). In the present study we found one perfect p53 RE located in the first intron of the gene encoding for CD58 (lymphocyte function Antig...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1476
更新日期:2002-02-01 00:00:00
abstract::Endogenous lectins of normal tissues can play a functional role in recognition processes and cell adhesion. These functions are areas of particular relevance to tumor growth and metastasis. Our initial results on endogenous lectins of different tumors lead to the working hypothesis that the pattern of endogenous lecti...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90118-5
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.05.002
更新日期:2008-09-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare dermatological condition belonging to the group of deep neutrophilic dermatoses. It can display a protracted and refractory course. The list of treatments which have been tried and proved their efficacy is long, but none of them provide constant efficacy. In the absence of gold stan...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2012.01.039
更新日期:2012-05-01 00:00:00
abstract::A role for lipopolysaccharides (endotoxins, LPS) in 7 the pathogenesis of Reye's syndrome (RS) has previously been suggested. Impairment of hepatic LPS clearance can lead to systemic endotoxemia as previous studies by this and other laboratories have suggested for several hepatic disorders including RS. Systemic LPS m...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90115-s
更新日期:1992-11-01 00:00:00
abstract::Surgery for intractable affective illnesses has generated considerable controversy over the last century. Deep brain stimulation (DBS) has revolutionized neurosurgical practice, especially in the field of advanced Parkinson's disease and, more recently, in selected medical-refractory cases of obsessive-compulsive diso...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.07.036
更新日期:2006-01-01 00:00:00
abstract::The modern living standard has imposed upon society a situation of chronic sleep deprivation. This chronic loss of sleep affects women more than it does men. As a result, the postponement of pregnancy has become a common choice due to the priority given to social and domestic activities. For women, pregnancy represent...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.07.036
更新日期:2010-12-01 00:00:00
abstract::The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.10.006
更新日期:2012-01-01 00:00:00
abstract::Most of the evidence of formation of amblyopia is derived traditionally from electrophysiological studies. Recently, there have been many discoveries from genetics, histopathology, biochemistry, immunology and interventional studies. On the basis of evidence gathered in the last five years, the various types of amblyo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90275-9
更新日期:1997-02-01 00:00:00
abstract::Chronic Fatigue Syndrome is a physiological state in which the patient feels high levels of fatigue without an obvious organic cause, which affects around 1 in 400 people in the developed world. A wide range of causes have been suggested, including immune or hormonal dysfunction, viral or bacterial infection, and psyc...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.02.022
更新日期:2008-10-01 00:00:00