Treatment of solid tumors and metastases by fibrinogen-targeted anticancer drug therapy.

Abstract:

:The accumulation of fibrin/fibrinogen and other coagulation factors in and around solid tumors and metastatic foci has been recognized for a century as an aspect of cancer pathology. On this basis, anticoagulants and fibrinolytic agents have been deployed as adjuvant anticancer therapies, but they have proved clinically useful for only a small proportion of tumors and they only control the functions of the coagulant components. Overuse or long-term application of anticoagulants and fibrinolytic agents often lead to undesirable side-effects. Here, we propose that anticancer drugs that act by different mechanisms can inhibit tumor-associated coagulation, and it may be possible to develop drugs that specifically targeting tumor-related coagulation, have specific cytotoxic effects on tumor and metastatic cells. We provide laboratory and clinical evidence supporting the hypothesis and offer proposals for future applications.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Lu DY,Chen XL,Ding J

doi

10.1016/j.mehy.2006.06.045

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

188-93

issue

1

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(06)00503-2

journal_volume

68

pub_type

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