Abstract:
:Infection of the lymphatic system by Wuchereria bancrofti microfilaria is the most common cause of elephantiasis, a disease that affects over 100 million people. The nightly release of microfilaria into the circulation coincides with the feeding activity of its mosquito vector, a synchronization that is presumably an evolutionary adaptation favoring survival and transmission of the parasite. During the daytime hours, the microfilaria are thought to be sequestered in the lungs, and because they are not exposed to the solar light/dark cycle, there must be some other cue that entrains their nightly release into the periphery. I hypothesize that the host's secretion of melatonin synchronizes the nocturnal release of the microfilaria. It follows that exogenous melatonin administration during the day would also trigger release of microfilaria in the blood and could be used as a provocative diagnostic test for filariasis.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Sack RLdoi
10.1016/j.mehy.2009.02.034subject
Has Abstractpub_date
2009-08-01 00:00:00pages
147-9issue
2eissn
0306-9877issn
1532-2777pii
S0306-9877(09)00196-0journal_volume
73pub_type
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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journal_title:Medical hypotheses
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更新日期:2017-01-01 00:00:00
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更新日期:2015-09-01 00:00:00
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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