Abstract:
:Skin photoaging, the most common skin damage, is caused by chronic UV irradiation. It is involved in the reduction, aging and apoptosis of fibroblasts (FBs) as well as the blockage of transforming growth factor-beta (TGF-β)/Smad and p38 mitogen-actived protein kinase (MAPK) signaling pathways. Dermal multipotent stem cells (dMSCs) are a population of adult stem cells derived from dermis in recent years. It has been confirmed that dMSCs can activate or differentiate into FBs to participate in wound healing by producing and expressing TGF-β and other cytokines. Considering the mechanism of skin photoaging and the role of dMSCs, we hold a hypothesis that dMSCs may be applied in skin photoaging by activating TGF-β/Smad and p38 MAPK signaling pathways, and then stimulating FBs to secrete and synthesize collagen or elastin, heightening the extracellular matrix, finally eliminating wrinkles and strengthening skin elasticity. These would provide a novel approach for anti-skin photoaging.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Zhong J,Hu N,Xiong X,Lei Q,Li Ldoi
10.1016/j.mehy.2010.10.035subject
Has Abstractpub_date
2011-03-01 00:00:00pages
343-6issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(10)00448-2journal_volume
76pub_type
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 社论
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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