Drugs that induce neutropenia/agranulocytosis may target specific components of the stromal cell extracellular matrix.

abstract：:Neurofibromatosis 1 is a common heritable disorder. The gene causing neurofibromatosis 1 had been recognized and the protein encoded by this gene, neurofibromin, was supposed to play a role in development of various tissues. Neurofibromin was found to have GTP-ase (GAP) domain against small p21 ras. IQGAP1 is another ...

journal_title：Medical hypotheses

authors： Abdel-Wanis ME,Kawahara N

更新日期：2001-03-01 00:00:00

abstract：:The internal thoracic arteries (ITAs) are a source of "noncoronary collateral circulation" (NCCC), or "noncoronary collateral blood flow" (NCCBF). The hypothesis herein is that enhancement of NCCC may represent an alternative means of myocardial blood supply: (1) Ligature of the ITAs creates a local hypertensive statu...

journal_title：Medical hypotheses

authors： Picichè M,Kingma JG Jr,Fadel E,Dagenais F,Robillard J,Simard D,Voisine P

更新日期：2010-01-01 00:00:00

abstract：:Although frequently disseminated to other anatomical sites, neuroblastoma (NB) is rarely reported as involving the central nervous system (CNS), which may reflect insufficient research in poorly controlled systemic disease. Here we demonstrate the involvement of the CNS in patients with NB over 18 months of age at dia...

journal_title：Medical hypotheses

authors： Odone-Filho V,Cristofani LM,Maluf PT,Almeida MTA,Halley N,Vince CSC,de Azambuja AMP,Brumatti M,Lubraico P,da Camara Lopes LHA,Leite KRM,Silva JLF,Plese JPP,Weltman E

更新日期：2020-03-01 00:00:00

abstract：:Intractable epilepsy has always posed a challenge to management; conventional, surgical and alternative techniques available so far (e.g., vagal nerve stimulation, i.e. VNS). The author has attempted to search for a novel alternative (drug-regime) approach to its management to minimise any invasive technique or surger...

journal_title：Medical hypotheses

authors： Jaseja H

更新日期：2003-08-01 00:00:00

abstract：:The ability of tumor cells to differentiate in combination with their ability to express genes that are not expressed in normal tissues, may result in the emergence of new cell types in evolution. Tumors may play an evolutionary role by providing conditions (space and resources) for the expression of newly evolving ge...

journal_title：Medical hypotheses

authors： Kozlov AP

更新日期：2010-01-01 00:00:00

abstract：:Several earlier observations by us and other investigators led us to propose a thesis that B lymphocytes, when activated by a virus, allo-antigen or bacterial protein would enter into effector arm of the immune response and cause allograft and tumor rejection or GVH-type of lesion in immunosuppressed animals. These ef...

journal_title：Medical hypotheses

authors： Krishnan G

更新日期：1990-05-01 00:00:00

abstract：:This article reviews the biochemical and physiological observations underpinning the synergism between ghrelin and ghrelin agonists with exercise, especially progressive resistance training that has been shown to increase muscle mass. The synergy of ghrelin agonists and physical exercise could be beneficial in conditi...

journal_title：Medical hypotheses

authors： Fuoco D,Kilgour RD,Vigano A

更新日期：2015-12-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a complex and heterogeneous disease characterized by central obesity, impaired glucose metabolism, dyslipidemia, arterial hypertension, insulin resistance and high-sensitivity C-reactive protein. In 2006, a neurotrophic hypothesis of the etiopathogenesis of MetS was launched. This hypothes...

journal_title：Medical hypotheses

authors： Hristova MG

更新日期：2013-10-01 00:00:00

abstract：:Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modificati...

journal_title：Medical hypotheses

authors： Gavin DP,Chase KA,Sharma RP

更新日期：2011-07-01 00:00:00

abstract：:Antisense oligonucleotides (oligos) have demonstrated efficacy for the treatment of various cancers, infectious diseases and metabolic disorders. While most studies have utilized single oligos either administered alone, or more recently in combination therapy with other drugs, some investigators have administered more...

journal_title：Medical hypotheses

authors： Rubenstein M,Tsui P,Guinan P

更新日期：2005-01-01 00:00:00

abstract：:Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disease with no known cause. There are many clues to suggest an environmental trigger for the disease, including reports of conjugal couples and co-localized employees that developed sALS. On the island of Guam,a very high incidence of sALS occ...

journal_title：Medical hypotheses

authors： Stommel EW,Field NC,Caller TA

更新日期：2013-02-01 00:00:00

abstract：:Studies have reported an increasing incidence of thyroid cancer worldwide. The reasons are likely related to improved imaging modalities, altered histopathologic criteria for diagnosis of thyroid cancer, and nuclear exposure. However, the classical assumption derived from epidemiological studies is that it should be q...

journal_title：Medical hypotheses

authors： Gursoy A

更新日期：2010-01-01 00:00:00

abstract：:Schizophrenia, if not the most difficult, is one of the most difficult mysterious puzzles for psychiatrists, psychologists, and neuroscientists to solve. In this paper, based on the previously known pathologies of schizophrenia, a new model is proposed for explanation of the formation of positive psychotic symptoms of...

journal_title：Medical hypotheses

authors： Javanbakht A

更新日期：2006-01-01 00:00:00

abstract：:Most of the body iron is found within hemoglobin in red cells (the erythron), a smaller amount being distributed in other tissues such as muscles and in deposits. Iron homeostasis is a finely tuned process in which the most important regulators are probably the liver-derived hepcidin which blocks iron absorption and d...

journal_title：Medical hypotheses

authors： Cucuianu A,Patiu M,Trifa AP,Tomuleasa C,Dima D

更新日期：2014-11-01 00:00:00

abstract：:An increase in pro-inflammatory cytokines, decrease in endothelial nitric oxide (eNO) and adiponectin levels and an alteration in hypothalamic peptides and gastrointestinal hormones such as incretins and cholecystokinin that regulate satiety, hunger, and food intake occur in metabolic syndrome. Thus, metabolic syndrom...

journal_title：Medical hypotheses

authors： Das UN

更新日期：2011-03-01 00:00:00

abstract：:Epidemiological findings on the relation between foods and colon cancer are inconsistent. Many, but far from all, found positive associations for meat and fat and negative ones for vegetables and fruits. Explanations so far have focused on direct biochemical conversions in the colon or transit time, but they remain un...

journal_title：Medical hypotheses

authors： Holmqvist OH

更新日期：2000-03-01 00:00:00

abstract：:Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Speci...

journal_title：Medical hypotheses

authors： Balaji A,Bhuvaneswari S,Kumar DN

更新日期：2020-11-01 00:00:00

abstract：:The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousn...

journal_title：Medical hypotheses

authors： Tonello L,Cocchi M,Gabrielli F,Tuszynski JA

更新日期：2017-04-01 00:00:00

abstract：:Ever since antimicrobial therapy was introduced, two phenomenons have been observed: drug resistance and host toxicity. Mutation(s) in microbes leads to the earlier, while off target effects of therapy cause the latter. Neither of these problems have yet to be resolved. All Microbes express specific antigens, against ...

journal_title：Medical hypotheses

authors： Singla M

更新日期：2007-01-01 00:00:00

abstract：:The N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common form of autoimmune encephalitis. Antibodies against the GluN1 subunit of the NMDAR showed in primary cultures of rat hippocampal neurons and in a mouse model pathogenic effects including cross-linking and internalization of the target receptors ...

journal_title：Medical hypotheses

authors： Ismail FS,Faustmann PM

更新日期：2020-06-01 00:00:00

abstract：HYPOTHESIS:The delayed lung damage after SARS-CoV-2 infection may be caused by an autoimmune response to ACE2 induced by forced presentation of the ACE2 protein in a complex with CoV Spike in Fc Receptor positive Antigen Presenting Cells in the lung. The likelihood that this hypothesis is valid is low, but it is easily...

journal_title：Medical hypotheses

authors： Townsend A

更新日期：2020-11-01 00:00:00

abstract：:It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/H...

journal_title：Medical hypotheses

authors： Bhattacharyya D

更新日期：2020-11-01 00:00:00

abstract：:The limb remote ischaemia postconditioning (RIPOC), a newly conceived idea of applying brief limb ischaemic stimulus after onset of the myocardial ischaemia but prior to the reperfusion, can offer the possibility of applying this cardioprotective strategy to the patients with acute myocardial infraction. Although incr...

journal_title：Medical hypotheses

authors： Xu YC,Xue FS,Liao X,Xiong J,Yang QY,Wang WL,Zhang YM

更新日期：2009-09-01 00:00:00

abstract：:The few existing hypotheses for the function of the human hymen are weak. These are briefly reviewed, and a new hypothesis is proposed. We suggest that the appearance of the juvenile human hymen is based on 'premature' birth, following which infant helplessness and a subsequent advantage for vaginal protection from ex...

journal_title：Medical hypotheses

authors： Hobday AJ,Haury L,Dayton PK

更新日期：1997-08-01 00:00:00

abstract：:Dental tissues contains stem cells or progenitors that have high proliferative capacity, are clonogenic in vitro and demonstrate the ability to differentiate to multiple type cells involving neurons, bone, cartilage, fat and smooth muscle. Numerous experiments have demonstrated that the multipotent stem cells are not ...

journal_title：Medical hypotheses

authors： Xin LZ,Govindasamy V,Musa S,Abu Kasim NH

更新日期：2013-10-01 00:00:00

abstract：:In this communication I propose a technique for manipulating the idiotype anti-idiotype network with the aim of enhancing the immune response to tumors. The theoretical basis for this technique follows from Jerne's network theory of the immune system. By tolerizing the host to immunoglobulin bearing idiotypes directed...

journal_title：Medical hypotheses

authors： Sharpe RJ

更新日期：1985-11-01 00:00:00

abstract：:Treatment-resistant schizophrenia (TRS) is one of the subgroups of schizophrenia of which little is known with regard to its optimal mechanism. Treatment response, either as full remission of symptoms or prediction by biomarker, is important in psychiatry. We have proposed a model that integrates dopaminergic and glut...

journal_title：Medical hypotheses

authors： Huang LC,Lin SH,Tseng HH,Chen KC,Yang YK

更新日期：2020-10-01 00:00:00

abstract：:In early synovitides the tissue inflammatory cell reaction is often weak and sometimes absent, many alterations being consistent with nonvasculitic exudation (I). Increased permeability to protein may require little, if any, endothelial damage. In rheumatoid arthritis (RA) increased transfer of fluid and protein from ...

journal_title：Medical hypotheses

authors： Ahlqvist J

更新日期：1982-07-01 00:00:00

abstract：:A consistent accumulation of experimental evidence, most of it published long ago, clearly shows that a constant consequence of the immune response elicited by the Koch bacillus is that the individual becomes susceptible to be injured or killed by the tuberculous antigen, which is totally innocuous to the virgin subje...

journal_title：Medical hypotheses

authors： Rivarola AJ

更新日期：1987-08-01 00:00:00

abstract：:In light of the progressive, pubertal increases in serum gonadotropin (FSH, LH) levels coinciding with the peak incidence of simple goiters; the common alpha subunits associated with the gonadotropins, TSH and hCG; the ability of LH and hCG to bind to thyroid TSH receptors and affect thyroid function; and, the probabl...

journal_title：Medical hypotheses

authors： DiNicola AF

更新日期：1983-04-01 00:00:00