Abstract:
:Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modifications. This has implications for psychotherapy and long-term rehabilitation of CNS disorders. We hypothesize that by enhancing learning through pharmacologically manipulating 'epigenetic' parameters, the effects of psychotherapies and rehabilitation can be enhanced.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Gavin DP,Chase KA,Sharma RPdoi
10.1016/j.mehy.2011.03.042subject
Has Abstractpub_date
2011-07-01 00:00:00pages
121-4issue
1eissn
0306-9877issn
1532-2777pii
S0306-9877(11)00154-Xjournal_volume
77pub_type
杂志文章abstract::Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarous...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.07.019
更新日期:2011-10-01 00:00:00
abstract::Dupuytren's disease is a pathological condition of the palmar fascia characterized by the formation of contractile disease cords that result in permanent finger contracture. This condition is believed to progress from a myofibroblast-rich nodule in the early clinical stages of the disease to a contractile disease cord...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.10.009
更新日期:2010-03-01 00:00:00
abstract::The U.S. Environmental Protection Agency's (EPA) proposed drinking water standard for radium-226 (226Ra) of 5 pCi/l is evaluated according to its health basis and carcinogenic implications. Proposed health risks of 226Ra in drinking water by other leading theoreticians (Evans, Gofman-Tamplin and Peterson) are also con...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(77)90002-0
更新日期:1977-09-01 00:00:00
abstract::The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The re...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.01.008
更新日期:2018-03-01 00:00:00
abstract::The understanding of the renin-angiotensin system (RAS) has significantly expanded over the last two decades. The elucidation of angiotensin-converting enzyme 2 (ACE2) that converts angiotensin (Ang) II into Ang (1-7) led to the discovery of the cardio-protective axis of the RAS. In addition, novel components of the s...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110038
更新日期:2020-11-01 00:00:00
abstract::As known, gamma-interferon-induced cell death in HeLa cells can be mediated via the recently identified protein kinase, death associated protein (DAP) kinase which is localized to the microfilament system of the cytoskeleton. However, the downstream or upstream effectors of DAP kinase remain uncertain. In the present ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0967
更新日期:2000-05-01 00:00:00
abstract::Vasopressin is now commonly used to control bleeding during surgery of the cervix. In larger intravenous doses, vasopressin can cause coronary artery vasoconstriction and increase systemic vascular resistance. Nicotine has a similar effect on the coronary circulation. The effects of combining both these drugs has not ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90036-5
更新日期:1996-07-01 00:00:00
abstract::A new collection of ideas from Medical Hypotheses by Roger Dobson is entitled Death can be cured and 99 other Medical Hypotheses. It consists of humorous summaries of Medical Hypotheses articles from the past 30 years. The book's humour derives mainly from the subject matter, although sometimes also from the 'unconven...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2008.01.016
更新日期:2008-01-01 00:00:00
abstract::Since forced unilateral nostril breathing activates the contralateral brain hemisphere, an animal analogue of this technique could be provided by methylmethacrylate gluing large plastic pellets in either the right or left nostrils in a group of rats. A large number of physiological, pharmacological, and immunological ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90047-9
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Pregnancy is characterized by multiple metabolic processes to allow proper foetal development and ensure adequate stores. Little is known about the interactions between maternal and foetal metabolism during the last phase of pregnancy. Metabolomic offers potential to discover changes in maternal metabolism i...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109543
更新日期:2020-04-01 00:00:00
abstract::Autism is a pervasive developmental disorder that is characterized by the behavioral traits of impaired social cognition and communication, and repetitive and/or obsessive behavior and interests. Although there are many theories and speculations about the pathogenetic causes of autism, the disruption of the serotonerg...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.01.002
更新日期:2013-04-01 00:00:00
abstract::It is hypothesized that Alzheimer's disease is a human phylogenetic disease which has a common multifactorial pathogenesis in sporadic and familial cases and in Down syndrome, related to a genomic character function G(x). Increments in G(x) accompanied the increased gene expression that sustained brain growth and diff...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90185-0
更新日期:1989-07-01 00:00:00
abstract::September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Pop...
journal_title:Medical hypotheses
pub_type: 传,社论,历史文章
doi:10.1016/j.mehy.2009.09.021
更新日期:2009-12-01 00:00:00
abstract::In UK educational circles it has long been regarded as a platitude that a good scientific education at school and undergraduate level should aim to teach critical thinking and encourage students to challenge mainstream science, debate scientific issues and express their personal opinions. However, I believe that this ...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2009.07.050
更新日期:2010-02-01 00:00:00
abstract::Over-degradation of extracellular components by matrix metalloproteinases (MMPs) has been implicated as an important characteristic during the pathological evolution of the abdominal aortic aneurysm (AAA) and cerebral aneurysm (CA), which contribute to progressive dilation of vascular wall. However, mRNA and protein e...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.06.062
更新日期:2007-01-01 00:00:00
abstract::From biographical data sources on ranking scientists, I was able to identify 35 centenarians. Among these, only one (Michel Chevereul from France) lived before the 20th century. Since the remaining 34 individuals became centenarians only from 1965, I propose that centenarian scientists are an unusual cluster, first fo...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1054/mehy.2001.1480
更新日期:2001-12-01 00:00:00
abstract::A high incidence of sudden unexplained nocturnal deaths has been reported among young Asian males. These deaths are known as Pokkuri in Japan, Bangungut in the Philippines and Sudden Unexplained Nocturnal Death in the United States. Post mortem analysis has demonstrated cardiac conduction defects in many of the victim...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90071-0
更新日期:1988-06-01 00:00:00
abstract::The paper based on the hypothesis that mechanical impulses cause the transmission of excitement in the peripheral and central nervous system. Possible connections between changes in the tubular neuronal network and the morphological findings of Alzheimer's disease are presented. Additionally, changes in the viscosity ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.02.012
更新日期:2014-05-01 00:00:00
abstract::NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation ...
journal_title:Medical hypotheses
pub_type: 信件
doi:10.1016/j.mehy.2020.109968
更新日期:2020-11-01 00:00:00
abstract::Intrauterine growth retardation (IUGR) is associated with insulin resistance, non-insulin-dependent diabetes mellitus (NIDDM) and cardiovascular diseases in adulthood. Postnatal tissues contain stem cells that though quiescent, retain their capacity to self-renew and regenerate tissues to fulfil organ demands. I propo...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00182-8
更新日期:2003-09-01 00:00:00
abstract::A novel substance-attributed biophysical theory of brain-mind unity is presented. We separate spiritualism and matters of the soul from the medical sphere. Biophysical principles are responsible for the body's operational regimen (BOR) in the homeostatic state which allows for materialization and emergence of the mind...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0852
更新日期:2000-03-01 00:00:00
abstract::ATP sensitive (K(+)(ATP)) potassium cardiac channels are recruited when ATP levels are low as in ischemic injury and acute trauma. Such activation results in ECG-ST elevation and cardiac arrhythmias. K(+)(ATP) channel recruitment may be blocked by the sulfonylurea glibenclamide, permitting a wide variety of animal exp...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00055-0
更新日期:2003-04-01 00:00:00
abstract::Recent findings indicate a principal role for Hepcidin in iron homeostasis. Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease. Under normal conditions influx and efflux of iron from duodenal enterocytes is regulated by Ferroportin. Fer...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.10.007
更新日期:2008-01-01 00:00:00
abstract::A new hypothesis is presented to explain some aspects of human smoking behaviour. While acknowledging the importance of the nicotine self-titration phenomenon, changes in puffing intensity during the smoking of a single cigarette are related not to the control of nicotine uptake but to the modification of cigarette sm...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90087-8
更新日期:1985-08-01 00:00:00
abstract::A five-step hypothesis on the pathogenesis of Hodgkin's disease (HD) is presented. Weak immune suppressor activity gives a predisposition for the development of the disease, after which a non-specific immune stimulation can initiate a self-perpetuating uncontrolled stimulation between interdigitating cells (IDCs), mac...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(84)90156-7
更新日期:1984-12-01 00:00:00
abstract::Yawning is a stereotyped event that occurs in humans and animals from fish to mammals, but neither its mechanisms nor its functions are entirely known. Its widespread nature suggests that it has important physiological functions. It is associated with stretching of muscles in a large area, but the function of this str...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.027
更新日期:2008-01-01 00:00:00
abstract::The S-oxidation of S-carboxymethyl-l-cysteine has been reported previously to be a biomarker of disease susceptibility in Parkinson's disease and Amyotrophic lateral sclerosis. In this investigation, the original observations have been confirmed with the incidence of the poor metaboliser phenotype (no urinary recovery...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.06.018
更新日期:2018-09-01 00:00:00
abstract::Knowledge about how information is stored in neurons of animals and in the human brain is still incomplete. A hypothesis related to long-term changes in synaptic efficiency has strong experimental support, but does not seem to be able to explain all observations. It has recently been proposed that magnetite together w...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.07.003
更新日期:2018-10-01 00:00:00
abstract::For almost 70 years, essential fatty acid deficiency has been known to be associated with skin disorders, vessel abnormalities, and increased tumorigenesis. However, the underlying molecular and cellular mechanism is largely unknown. Recently, it has been reported that essential fatty acids regulate cell adhesion by m...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1998.1191
更新日期:2000-09-01 00:00:00
abstract::The present study developed a feature selection (FS)-based decision support system using the electroencephalography (EEG) signals recorded from neonates with and without seizures. The study employed 10 different FS algorithms to reduce the classification cost by using fewer features and to improve the classification p...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109464
更新日期:2020-02-01 00:00:00