Biophysical body-brain-mind unity: theory and practice.

abstract：:Recent investigations on protease inhibitors in articular cartilage have provided new insights into the possible initial lesions of osteoarthrosis. A hypothesis has been formulated based upon an impaired ability of chondrocytes to synthesize protease inhibitors, which leads to loss of matrix integrity and vascular inv...

journal_title：Medical hypotheses

authors： Stephens RW,Ghosh P,Taylor TK

更新日期：1979-07-01 00:00:00

abstract：:Crossed cerebellar diaschisis (CCD) refers to transneuronal degeneration of the corticopontocerebellar pathway, resulting in atrophy of cerebellum contralateral to supratentorial pathology. CCD is traditionally diagnosed on nuclear medicine studies. Our aim is to apply a biexponential diffusion model, composed of intr...

journal_title：Medical hypotheses

authors： Kohannim O,Huang JC,Hathout GM

更新日期：2018-11-01 00:00:00

abstract：:Atherosclerosis and its fatal complications, such as myocardial infarction or stroke, represent the most common cause of morbidity or mortality in modern world. It was observed that an excess of reactive oxygen species (ROS) accompanies atherosclerosis. Under physiological circumstances, intracellular H+ accumulates a...

journal_title：Medical hypotheses

authors： Zheng Z,Zhang Z,Wang M

更新日期：2020-08-01 00:00:00

abstract：:Historically, cluster reports have been considered to be only marginally productive and generally discouraged as statistical artifacts. This report presents the results of a three year study involving in excess of 100 cancer cluster reports. The majority of these investigations represented statistical events; there we...

journal_title：Medical hypotheses

authors： Aldrich TE,Garcia N,Ziechner S,Berger S

更新日期：1983-09-01 00:00:00

abstract：UNLABELLED:Physiological acts present the puzzle that we are unable to explain how we performed them, how we solved the technical difficulties involved in their execution. For instance, when we sing, we produce various musical notes by changing the shape of the larynx. The normal person does not even know what the lary...

journal_title：Medical hypotheses

authors： Seely S

更新日期：2002-12-01 00:00:00

abstract：:In a recent paper it was argued that all stem cells are small motile cells, the haemopoietic stem cell being no exception. Although haemopoietic stem cells arise and mature in an extravascular milieu, they are present in small numbers in the peripheral circulation, where they have a lymphocyte-like appearance, and in ...

journal_title：Medical hypotheses

authors： Drummond R

更新日期：1994-09-01 00:00:00

abstract：:Dysbiosis is a prominent feature of inflammatory bowel diseases (IBD). However, the efficacy of using antibiotics aiming at the aberrant gut microflora for IBD treatment are either unsuccessful or not persistent. In contrast, long-term oral vancomycin has been proved effective in controlling both the bile duct and gut...

journal_title：Medical hypotheses

authors： Du W,Han W,Dong J

更新日期：2020-11-01 00:00:00

abstract：:Recently, a theory has been postulated that suggests that vital enzymes in ingested food interact synergistically with enzymes within the human body and more specifically with enzymes in the digestive tract. Alterations in food enzymes induced by bulk processing including heating and irradiation and also the addition ...

journal_title：Medical hypotheses

authors： Prochaska LJ,Piekutowski WV

更新日期：1994-06-01 00:00:00

abstract：:This hypothesized reflex relates the vertical direction of gaze to the amount of tension exerted by the ciliary muscle. Based on simple observations the following is assumed. When looking downwards a tendency for closer focusing (near searching) exists even without a specific visual stimulus, whereas looking up favors...

journal_title：Medical hypotheses

authors： Blumenthal EZ

更新日期：1991-12-01 00:00:00

abstract：:Jet lag is a travel-induced circadian rhythm phenomenon that afflicts healthy individuals following long- distance flights through several time zones. The typical jet-lag manifestations - insomnia during local sleep time, day fatigue, reduced concentration, irritability, and exhaustion with mild depression - are attri...

journal_title：Medical hypotheses

authors： Katz G,Durst R,Zislin Y,Barel Y,Knobler HY

更新日期：2001-01-01 00:00:00

abstract：:Erectile dysfunction after nerve injury is a common disease after radical prostatectomy. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which plays an important role in the survival of existing neurons, the differentiation of new neurons, and synaptic plasticity. It has been demonstra...

journal_title：Medical hypotheses

authors： Chiang PK,Yang FY

更新日期：2019-01-01 00:00:00

abstract：:All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibil...

journal_title：Medical hypotheses

authors： Cai DW

更新日期：1995-05-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play an essential role in tumor-associated immunosuppression, which hampers effective immunotherapeutic approaches. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate target gene expression at the posttranscriptional level...

journal_title：Medical hypotheses

authors： Tian J,Rui K,Wang S

更新日期：2014-08-01 00:00:00

abstract：:The incidence rate of cutaneous melanoma has been increasing faster than that of any other cancer in white-skinned populations over the past decades. The main risk factors for melanoma (i.e. exposure to sunlight, naevus count, phototype, and family history of melanoma) may not wholly explain the epidemiological trends...

journal_title：Medical hypotheses

authors： Kvaskoff M,Weinstein P

更新日期：2010-09-01 00:00:00

abstract：:Pre-implantation genetic diagnosis (PGD) is a powerful clinical tool to identify embryos with or at risk of specific genetic diseases before implantation in utero after in vitro fertilization (IVF). PGD is performed on embryo biopsies that are obtained by aspiration of one or two cells from pre-implantation embryos at...

journal_title：Medical hypotheses

authors： Assou S,Aït-Ahmed O,El Messaoudi S,Thierry AR,Hamamah S

更新日期：2014-10-01 00:00:00

abstract：:There are large amounts of zinc in muscle and zinc ions can enhance the degree of muscle contraction in response to direct stimulation while at the same time inhibiting neuromuscular transmission. The opposites of these effects would lead to myotonia and muscle weakness. There are many parallels between the non-muscul...

journal_title：Medical hypotheses

authors： Horrobin DF,Morgan RO

更新日期：1980-04-01 00:00:00

abstract：:Acute renal failure (ARF) is a rapid loss of kidney function. The reasons and mechanism by which this occurs has not been clarified so far thus creating obstacles to management of this disease. Presently, the experimental research using the accepted renal ischemia reperfusion injury (I/R injury) model represented for ...

journal_title：Medical hypotheses

authors： Hao JL,Li YF,Li RS

更新日期：2013-04-01 00:00:00

abstract：:The etiology of most kinds of dementia is still obscure and is probably multifactorial. We query whether excessive watching of television may contribute to the development of dementive processes for the following reasons: TV spectators are exposed to a mass of successive and rapid stimuli with little or no possibility...

journal_title：Medical hypotheses

authors： Aronson M

更新日期：1993-11-01 00:00:00

abstract：:COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and lethality of the infection. Macrophages are innate immune cells th...

journal_title：Medical hypotheses

authors： Pagliaro P

更新日期：2020-10-01 00:00:00

abstract：:The new prion diseases that have emerged in the last 15 years are bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (variant CJD). Although initially confined to the UK, these diseases have recently emerged in other European countries. The accepted cause of the human disease is that BSE spre...

journal_title：Medical hypotheses

authors： Brown DR

更新日期：2001-11-01 00:00:00

abstract：:Growing evidence has indicated the existence of deleterious networks in the brains of neurodegenerative disorders, including Alzheimer's disease. Parkinson's disease, amyotrophic lateral sclerosis and Huntington's disease. The deleterious networks are formed on the basis of the intimate interactions among the key path...

journal_title：Medical hypotheses

authors： Ying W

更新日期：1996-10-01 00:00:00

abstract：:In a previous paper, I have proposed that the deficiency of an endogenous caffeine-like substance is the underlying pathogenic mechanism in schizophrenia (1). In the present paper, my new concept is used to explain many of the clinical, biochemical, radiologic and pharmacologic facts about schizophrenia. ...

journal_title：Medical hypotheses

authors： Missak SS

更新日期：1991-10-01 00:00:00

abstract：:In this editorial, we provide concise suggestions to help individuals decide what scientific papers to read and how to read them. We do so because--like others--we are frequently asked by people with interest in science as to how to effectively surf today's information tsunami. This is particularly important in, but n...

journal_title：Medical hypotheses

authors： Erren TC,Cullen P,Erren M

更新日期：2009-09-01 00:00:00

abstract：:Given the reports made about dogs detecting cancer on the basis of odour, our hypothesis is that the volatile organic compounds produced by tumours, and detected by dogs, are products of MHC genes. Two lines of evidences support this hypothesis: (1) human body odour is genetically determined by MHC. These antigen mole...

journal_title：Medical hypotheses

authors： Balseiro SC,Correia HR

更新日期：2006-01-01 00:00:00

abstract：:Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin:light therapy is hypothesized to be mediated by superoxide. ...

journal_title：Medical hypotheses

authors： Peterson DA,McKelvey S,Edmondson PR

更新日期：1981-02-01 00:00:00

abstract：:Chlorination of potable water supplies high in organics may yield carcinogenic compounds such as trihalomethanes. Chlorine dioxide has been proposed as an alternative disinfectant to chlorine. However, chlorine dioxide is a strong oxidant that forms significant amounts of chlorite when added to potable water supplies,...

journal_title：Medical hypotheses

authors： Moore GS,Calabrese EJ,DiNardi SR,Tuthill RW

更新日期：1978-09-01 00:00:00

abstract：:The present study developed a feature selection (FS)-based decision support system using the electroencephalography (EEG) signals recorded from neonates with and without seizures. The study employed 10 different FS algorithms to reduce the classification cost by using fewer features and to improve the classification p...

journal_title：Medical hypotheses

authors： Açıkoğlu M,Tuncer SA

更新日期：2020-02-01 00:00:00

abstract：:Knowledge about how information is stored in neurons of animals and in the human brain is still incomplete. A hypothesis related to long-term changes in synaptic efficiency has strong experimental support, but does not seem to be able to explain all observations. It has recently been proposed that magnetite together w...

journal_title：Medical hypotheses

authors： Alfsen EM,Størmer FC,Njå A,Walløe L

更新日期：2018-10-01 00:00:00

abstract：:In attempts to develop a rational anticancer strategy the same homologous tissue in 3 conditions were used side by side as targets: normal epidermis of the mouse back. Tween 60R-provoked benign epidermal hyperplasia, and carcinogen-provoked malignant condition. In contrast to the highest tolerated doses of the cytosta...

journal_title：Medical hypotheses

authors： Setälä K

更新日期：1982-03-01 00:00:00

abstract：:It is proposed that there is biological regulation of the low molecular weight antioxidant (LMWA) status of the body, and that these different antioxidants work in concert and in homeostasis as a system analogous to the regulation of acid-base status (pH). The theoretical design characteristics for such a system inclu...

journal_title：Medical hypotheses

authors： Berry EM,Kohen R

更新日期：1999-11-01 00:00:00