Abstract：
:Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play an essential role in tumor-associated immunosuppression, which hampers effective immunotherapeutic approaches. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate target gene expression at the posttranscriptional level. miRNAs are involved in regulating cell proliferation, differentiation and maturation, and abnormal expression and function of miRNAs are recognized in various human diseases. Accumulating evidence shows that various miRNAs modulate the development and differentiation of myeloid cells, which implies their possible role in the differentiation of MDSCs into mature myeloid cells. Our recent studies have found that the classical myeloid differentiation related gene runt-related transcription factor 1 (Runx1) and target nuclear factor 1/A (NFI-A) are modulated during the differentiation and maturation of MDSCs while six miRNAs are found to possibly regulate these two targets by miRNA array analysis. Thus, we hypothesize that the predicted miRNAs may modulate the target genes to regulate the differentiation and maturation of MDSCs. Further studies will provide a novel potential approach for tumor immunotherapy.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Tian J,Rui K,Wang Sdoi
10.1016/j.mehy.2014.05.006subject
Has Abstractpub_date
2014-08-01 00:00:00pages
151-3issue
2eissn
0306-9877issn
1532-2777pii
S0306-9877(14)00210-2journal_volume
83pub_type
杂志文章abstract：:Submagnetic domain magnetic fluid particles of approximately 10 nm average diameter complexed with CD4 or monoclonal antibody and then injected into the patient, will localize to the cell membrane of the target cell. These ferrofluid particles will interact with an externally applied rotating magnetic field of rapidly...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90226-1
更新日期：1996-01-01 00:00:00
abstract：:Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuit...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.11.010
更新日期：2018-01-01 00:00:00
abstract：:Circumstantial evidence links neuropathological changes in postencephalitic Parkinson's disease and amyotrophic lateral sclerosis on Guam to the 1918 influenza pandemic. Postencephalitic Parkinson's disease and amyotrophic lateral sclerosis have neuronal neurofibrillary tangles that anatomically correlate with clinica...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1224
更新日期：2002-03-01 00:00:00
abstract：:Pro PSA, the precursor of PSA, is an inactive 244-amino acid protein secreted by prostatic cells. Pro PSA, a distinct molecular form of free PSA in serum, includes native as well as several truncated forms. Clinical studies have recently provided evidence that pro PSA is associated with prostate cancer (PCa). The trun...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.06.006
更新日期：2005-01-01 00:00:00
abstract：:Approximately 15 million Americans including over 5 million children suffer from asthma, the most common chronic disease in childhood. The prevalence of pediatric asthma has risen sharply over the past four decades, with the sharpest increases occurring in children younger than 6 years and in urban, predominantly mino...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.10.001
更新日期：2004-01-01 00:00:00
abstract：:The biology of natural selection is an enduring mystery, as is the nature of Charles Darwin's chronic illness. Of the theories advanced to explain the latter, Oedipal conflicts and Chagas' disease are preeminent. Hypomania, however, propelled Darwin to the pinnacle of scientific achievement and good health, the depres...
journal_title：Medical hypotheses
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.mehy.2007.03.013
更新日期：2007-01-01 00:00:00
abstract：:The biophysical processes during electroconvulsive therapy (ECT) are discussed. The multilayer head structure causes a shunting and spreading of the major portions of the current all over the extracranial tissues. The final effect is that only a small percentage of the injected current passes into the brain. The secon...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90052-3
更新日期：1994-08-01 00:00:00
abstract：:Hypotheses regarding the factors that predispose individuals to developing AIDS after exposure to HTLV-III/LAV are beginning to emerge. It is suggested here that surgical removal of tonsils in childhood may increase the risk of developing opportunistic infections after infection with this newly discovered retrovirus. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90076-9
更新日期：1986-03-01 00:00:00
abstract：:The author, in an attempt to clarify whether the rise of alternative medicine is a phenomenon characteristic of our time or whether it existed in the past as well, has identified at least three alternative medicines, which developed in ancient Rome, ancient India and in the medieval Islamic world. The circumstances le...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1054/mehy.2000.1061
更新日期：2000-10-01 00:00:00
abstract：:Oxidative stress plays a crucial role in a variety of clinical settings of atherogenesis, and mediates many pathways linked to atherosclerosis and inflammation. gamma-Glutamyltransferase (GGT), an enzyme responsible for the extracellular catabolism of antioxidant glutathione, may directly take part in atherogenesis an...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2006.04.010
更新日期：2006-01-01 00:00:00
abstract：:Consideration of nine major factors predisposing to cerebral thrombosis, coronary thrombosis or thrombosis in the deep veins of the calf, reveals that these factors all have one thing in common. Estrogen administration, pregnancy, ageing, smoking, infection, trauma, surgery, soft water and winter season are all associ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(79)90072-0
更新日期：1979-08-01 00:00:00
abstract：:Tinnitus and temporomandibular joint dysfunction (TMJD) are among the most common complaints encountered by physicians. Though the relationship between tinnitus and TMJD has attracted great interest during the past several years, theories attempting to explain this association are still few and inconsistent. Conceivab...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00194-4
更新日期：2003-10-01 00:00:00
abstract：:Initiation and development of atherosclerosis has largely been attributed to irregular shear stress patterns and values, in the current literature. Abnormalities such as low shear stress, reversing and oscillatory shear force patterns, as well as temporal variations of shear stress are the most cited factors. However,...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.04.041
更新日期：2013-08-01 00:00:00
abstract：:Bone grafting uses a wide range of materials derived mainly from exogenous sources. Autogenous teeth are often used fresh or fixed with alcohol for later use. Proposed here is a method of using cryogenically preserved autogenous extracted teeth, which could be macerated after thawing. This method avoids the possibilit...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.04.028
更新日期：2016-07-01 00:00:00
abstract：:The prevalence of autism has increased dramatically over the last 60 years, and the cause of this increase is unclear. In this paradigm-shift paper, I propose an explanatory paradigm for the cause of autism and its increased prevalence in the general population. I also discuss how social and historical contexts may ha...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110456
更新日期：2021-01-01 00:00:00
abstract：:In this work we propose a simple mathematical model for the analysis of the impact of control measures against an emerging infection, namely, the severe acute respiratory syndrome (SARS). The model provides a testable hypothesis by considering a dynamical equation for the contact parameter, which drops exponentially w...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.09.029
更新日期：2005-01-01 00:00:00
abstract：:Osteoarthritis (OA) is a chronic, degenerative disorder of multifactorial aetiology, characterized by loss of articular cartilage and periarticular bone remodelling. Goals of managing OA include controlling pain, maintaining and improving function and health-related quality of life, and limiting functional impairment....
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.01.084
更新日期：2007-01-01 00:00:00
abstract：:The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). T...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0701
更新日期：1999-07-01 00:00:00
abstract：:Oral submucous fibrosis (OSMF) is a potentially malignant disorder of the oral cavity. Most of the people affected by OSMF are betel quid chewers. It is characterized by epithelial atrophy and progressive accumulation of collagen fibers in lamina propria and submucosa of the oral mucosa. 7.6% of OSMF cases undergo ora...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.07.001
更新日期：2013-10-01 00:00:00
abstract：:Arthritis is inflammation in a joint often with joint damage, usually accompanied by pain, swelling and stiffness, resulting from infection, trauma, degenerative changes, metabolic disturbances, autoimmune or other causes. It occurs in various forms, including rheumatoid arthritis, osteoarthritis, bacterial arthritis ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.06.021
更新日期：2005-01-01 00:00:00
abstract：:Dental implants have been widely used in clinic for the restoration of lost teeth in recent decades, but there still remains a great challenge for even a higher success rate and a shorter rehabilitation time. The osseointegration between dental implant and alveolar bone tissue is crucial for a successful implantation....
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.05.013
更新日期：2008-10-01 00:00:00
abstract：:Clinical studies have shown that moderately intense physical activity effectively treats various types of depression. Beneficial effects have been reported in the acute phase of the disease as well as in a long-term perspective. In addition, epidemiological studies have shown that inactivity increases the risk of depr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.10.007
更新日期：2013-01-01 00:00:00
abstract：:It was hypothesized decades ago that reduced levels of brain monoamines such as serotonin or norepinephrine form, at least in part, a pathophysiological basis for major depression. Consistent with this hypothesis, a conventional strategy used, with varying success, to treat major depression involves administering anti...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.03.023
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Operative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has b...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.01.043
更新日期：2015-05-01 00:00:00
abstract：:Pyoderma gangrenosum (PG) is a rare dermatological condition belonging to the group of deep neutrophilic dermatoses. It can display a protracted and refractory course. The list of treatments which have been tried and proved their efficacy is long, but none of them provide constant efficacy. In the absence of gold stan...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2012.01.039
更新日期：2012-05-01 00:00:00
abstract：:The epidemiologic findings of Kaposi's sarcoma (KS) among patients with the acquired immunodeficiency syndrome (AIDS) suggest that human immunodeficiency virus (HIV) infection is insufficient for the development of KS. It was speculated that another sexually transmitted infection is responsible for the markedly increa...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90051-y
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:Pregnancy is characterized by multiple metabolic processes to allow proper foetal development and ensure adequate stores. Little is known about the interactions between maternal and foetal metabolism during the last phase of pregnancy. Metabolomic offers potential to discover changes in maternal metabolism i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109543
更新日期：2020-04-01 00:00:00
abstract：:A method for fast nucleotide sequencing is described. It is based in the selection of well-known small oligomers able to be hybridized with the unknown target. The selected oligomers are afterwards ordered following a simple statistical approach. The use of capillary electrophoresis for the analysis is emphasized. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.1026
更新日期：2000-07-01 00:00:00
abstract：:The hypothesis proposed is that restoration of functional capacity of denervated diaphragm may be achieved by reinervating it with vagus nerve. Following trauma, carcinomatose infiltration, and/or large thoracic surgery and neck surgery, phrenic nerve is frequently injured. Reinervation even in the most favourable con...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00414-0
更新日期：2003-03-01 00:00:00
abstract：:Intestinal dysbiosis refers to an imbalance in the intestinal flora. The concept of small intestinal bacterial overgrowth (SIBO), a condition of abnormal proliferation of the small intestine microbiota, has been proposed as a form of small intestine dysbiosis. In Parkinson's disease patients, weight loss and metabolic...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109436
更新日期：2020-01-01 00:00:00
