Abstract：
:Initiation and development of atherosclerosis has largely been attributed to irregular shear stress patterns and values, in the current literature. Abnormalities such as low shear stress, reversing and oscillatory shear force patterns, as well as temporal variations of shear stress are the most cited factors. However, clinical findings have further indicated that plaques have still been formed and developed in arterial sites that possess relatively more steady and higher shear stresses than those observed in studies correlating low or oscillatory shear stresses with atherosclerosis. These data imply that deviations in shear stress from its normal physiological pattern alone may not be the only factor inducing atherosclerosis, and additional haemodynamics parameter other then shear stress may also contribute to the initiation and development of plaques. In this paper, we hypothesise that the combined effect of wall shear stress and circumferential stress waves, in the form of angular phase difference between the two waves at each cardiac cycle, may be a more accurate determinant of plaque formation and growth. Furthermore, arterial sites that possess more positive values of this angular phase difference may be more prone to plaque formation or development. If proved correct, this theory can transform our understanding of endothelial cell mechanotransduction and mechanobiology, and may lead to design and utilisation of new diagnostic procedures and equipment as predictive and preventive clinical tools for patients with abnormal arterial blood pressure.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Anssari-Benam A,Korakianitis Tdoi
10.1016/j.mehy.2013.04.041subject
Has Abstractpub_date
2013-08-01 00:00:00pages
235-9issue
2eissn
0306-9877issn
1532-2777pii
S0306-9877(13)00222-3journal_volume
81pub_type
杂志文章abstract：:Many of the movement disorders seen in psychiatric patients are determined, in large part, by the dynamic balance of dopamine and acetylcholine in the basal ganglia. Gamma aminobutyric acid has effects on various neurotransmitters in the brain including dopamine and acetylcholine and is therefore relevant to a discuss...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(88)90008-4
更新日期：1988-12-01 00:00:00
abstract：:The globally increasing incidences of Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM) can have a common background. If challenged by the contemporary high level of nutritional glucose stimulation, the β-cells in genetically predisposed individuals are at risk for damage which can lead to the diseases. The fat to car...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.02.027
更新日期：2019-04-01 00:00:00
abstract：:Pyoderma gangrenosum (PG) is a rare dermatological condition belonging to the group of deep neutrophilic dermatoses. It can display a protracted and refractory course. The list of treatments which have been tried and proved their efficacy is long, but none of them provide constant efficacy. In the absence of gold stan...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2012.01.039
更新日期：2012-05-01 00:00:00
abstract：:Solutes concentration in the aqueous humor of the eye is highest near the ciliary processes in the posterior chamber (p.c.) and lowest near the trabecular meshwork in the anterior chamber (a.c.). The high osmotic gradient across the semipermeable iris causes it to easily move forward at this location and occasionally ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00338-9
更新日期：2003-03-01 00:00:00
abstract：:Endometriosis is a common gynecological disorder that affects approximately 6-10% of the female population impairing the quality of life of patients. Several pathophysiologic pathways have been proposed as potential regulators of its severity; however, to date, the processes that trigger the onset and that influence t...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2019.109414
更新日期：2019-12-01 00:00:00
abstract：:Postoperative delirium represents a serious complication after major surgery. Patients suffer from anxiety, hallucinations and delusions, and have higher postoperative morbidity and mortality. Generally, the role of acetylcholine deficiency in delirium pathophysiology is widely accepted. How this pathologic state evol...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.07.003
更新日期：2007-01-01 00:00:00
abstract：:Metabolic targeting of liver 5-aminolevulinate synthase (5-ALAS) by inhibition of heme utilisation by tryptophan (Trp) 2,3-dioxygenase (TDO) or the use of tryptophan is proposed as a therapy of acute hepatic porphyrias. 5-ALAS, the rate-limiting enzyme of heme biosynthesis, is under negative feedback control by a smal...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2019.109314
更新日期：2019-10-01 00:00:00
abstract：:The mechanisms by which blast pressure waves cause mild-to-moderate traumatic brain injury (mTBI) are an open question. Possibilities include acceleration of the head, direct passage of the blast wave via the cranium, and propagation of the blast wave to the brain via a thoracic mechanism. The hypothesis that the blas...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.08.015
更新日期：2009-01-01 00:00:00
abstract：:The ability of tumor cells to differentiate in combination with their ability to express genes that are not expressed in normal tissues, may result in the emergence of new cell types in evolution. Tumors may play an evolutionary role by providing conditions (space and resources) for the expression of newly evolving ge...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.07.027
更新日期：2010-01-01 00:00:00
abstract：:It has been shown previously that the precipitator hypothesis of causation is able to account for certain key features of the epidemiological evidence that conflict with initiator and promoter hypotheses. The precipitator hypothesis states that the carcinogenic risk depends linearly in the average rate of smoking at a...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90145-6
更新日期：1981-12-01 00:00:00
abstract：:It is sometimes asserted that UK science is thriving, at other times that it has declined. We suggest that both assertions are partly true because the UK is thriving with respect to the volume of 'normal' science production but at the same time declining in the highest level of 'revolutionary' science. Revolutionary s...
journal_title：Medical hypotheses
pub_type： 社论
doi：10.1016/j.mehy.2007.12.004
更新日期：2008-01-01 00:00:00
abstract：:For a number of years, the principal attention was accorded total serum cholesterol as a possible predictor of cardiovascular pathosis. More recently, emphasis has been shifted to the high-density lipoproteins (HDL). Now consideration is turning to the ratio of total serum cholesterol to high-density lipoproteins. In ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(82)90057-3
更新日期：1982-12-01 00:00:00
abstract：:Human immunodeficiency virus may regulate its replication by stimulating the synthesis of interleukin-1. Interleukin-1, in turn, has the ability to stimulate the human immunodeficiency virus enhancer region. The human genes responsible for interleukin-1 and interleukin-1 receptor antagonist synthesis are located on th...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90040-2
更新日期：1997-05-01 00:00:00
abstract：:Hepatopulmonary syndrome (HPS) is a severe pulmonary sequela which can affect up to 15% of patients with cirrhotic liver disease. There is no treatment for HPS other than liver transplantation. The cause of HPS is incompletely understood, but the pulmonary vasodilation in HPS is thought to be related to increased leve...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.10.017
更新日期：2004-01-01 00:00:00
abstract：:Rushton bodies (RBs) are one of the characteristic features seen in the epithelial lining of odontogenic cysts mainly radicular, dentigerous and odontogenic keratocyst. It has two different histo-morphological appearances; granular and homogeneous. Although widely investigated, the exact pathogenesis and histogenesis ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.06.007
更新日期：2016-08-01 00:00:00
abstract：:The most important obstacle for preventing hypertension is the belief that systemic hypertension has no identifiable cause. This belief, hiding the main offender, sodium chloride, causes too much time wasting for combating against hypertension. Accepting that sodium chloride is a drug and re-evaluating the situation a...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.02.024
更新日期：2006-01-01 00:00:00
abstract：:Most COVID-19 infected individuals present with mild flu-like symptoms; however, 5-10% of cases suffer from life-threatening pneumonia and respiratory failure. The pathogenesis of SARS-CoV-2 and its pathology of associated acute lung injury (ALI), acute respiratory distress syndrome (ARDS), sepsis, coagulopathy and mu...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109906
更新日期：2020-10-01 00:00:00
abstract：:Doppler sonography is used as a routine test for detection of renal artery stenosis (RAS). Although increased peak systolic velocity at the site of the narrowing is a widely accepted method for assessing main renal artery stenosis, tardus parvus phenomenon detected on the downstream blood flow has been used as an alte...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.01.016
更新日期：2019-03-01 00:00:00
abstract：:Epidemiologic literatures suggest that temporomandibular joint disorders (TMD) are more prevalent in women than in men. It is affecting approximately 7-15% of the adult population in North America, and 80% of patients treated for TMD are women. The severity of symptoms is also related to the age of the patients. The g...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.05.011
更新日期：2008-10-01 00:00:00
abstract：:Anorexia nervosa was explored as the possible expression of an aberration of the processing of information which ordinarily has value in life protection or extension. Each of 6 areas was briefly reviewed, and noted to have the potential for failure to balance 2 or more factors. Anorexia nervosa may prove to be a psych...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(90)90079-t
更新日期：1990-09-01 00:00:00
abstract：:Exercise-induced hypoalgesia is characterised by a reduction in pain sensitivity following exercise. Recently, low intensity exercise performed with blood flow restriction has been shown to induce hypoalgesia. The purpose of this manuscript is to discuss the mechanisms of exercise-induced hypoalgesia and provide ratio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109370
更新日期：2019-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.11.009
更新日期：2007-01-01 00:00:00
abstract：:Chronic Fatigue Syndrome is a physiological state in which the patient feels high levels of fatigue without an obvious organic cause, which affects around 1 in 400 people in the developed world. A wide range of causes have been suggested, including immune or hormonal dysfunction, viral or bacterial infection, and psyc...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.02.022
更新日期：2008-10-01 00:00:00
abstract：:Multiple reports show the efficacious usage of ECT for catatonia in individuals with autism. There are also a few reports showing that ECT improves self-injury in people with and without autism. In this hypothesis, self-injury in autism and other developmental disorders may be an alternate sign of catatonia, and as su...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.02.001
更新日期：2010-07-01 00:00:00
abstract：:Ampligen, a mismatched double stranded RNA, is hypothesized to be an ideal base therapy for HIV disease to which other agents, such as the nucleoside analogue, AZT, can be advantageously added. The unique properties of Ampligen which support this hypothesis include activation of immune cells, inhibition of virus repli...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90002-t
更新日期：1992-01-01 00:00:00
abstract：:Depression is often associated with insulin resistance, owing to cortisol overproduction; conversely, many studies suggest that diabetics are at increased risk for depression. Recent evidence indicates that insulin is transported through the blood-brain barrier and influences brain function via widely distributed insu...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90075-2
更新日期：1994-10-01 00:00:00
abstract：:The authors hypothesize that the impairment of hypothalamic-pituitary-gonadal axis in patients suffering from anorexia nervosa depends (at least in part) on the increased sensitivity to endogenous melatonin. The hypothesis is based mainly on the following facts: (1) melatonin is well known to exert an inhibitory effec...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0631
更新日期：1999-02-01 00:00:00
abstract：:The 2013 American Heart Association Blood Cholesterol Guidelines increased the number of patients recommended for statin therapy in the United States to 56million. Two common statin side effects are muscle pain, referred to as "statin-associated muscle symptoms", and increased risk for new onset type-2-diabetes mellit...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.07.007
更新日期：2017-09-01 00:00:00
abstract：:Incretin hormones have trophic effects on beta cell function that can aid prevention and treatment of diabetes. cAMP is the primary mediator of these effects, and has been shown to potentiate glucose-stimulated insulin secretion, promote proper beta cells differentiation by increasing expression of the crucial transcr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.04.031
更新日期：2006-01-01 00:00:00
abstract：:Innumerable studies have been carried out by people to trace out those elements, find out the mechanisms that are vital to the maintenance of stemness. Amongst them, the one which is gaining importance in the recent past is the metabolism of stem cells, especially One carbon metabolism. Being associated directly or in...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.12.019
更新日期：2018-02-01 00:00:00
