Abstract：
:Rushton bodies (RBs) are one of the characteristic features seen in the epithelial lining of odontogenic cysts mainly radicular, dentigerous and odontogenic keratocyst. It has two different histo-morphological appearances; granular and homogeneous. Although widely investigated, the exact pathogenesis and histogenesis of RBs is still an enigma. Many hypotheses were made in the literature but none has explained conceivably the two histo-morphological appearances of RBs and their association with inflammation. In the present paper the various pathogenesis for the formation of RBs proposed till date are discussed along with proposal for a novel hypothesis. The given hypothesis is mainly related to inflammation and its effect on pore size of basement membrane of odontogenic cystic epithelium. It explains RBs association with inflammation as well as existence of two histo-morphological appearances. The proposed hypothesis also justifies the RB's presence inside the lining epithelium of odontogenic cyst despite its hematogenous origin. Future studies are advocated for isolating RBs using laser capture microdissection and subsequent biochemical, histochemical and electron microscopic analysis to substantiate the proposed hypothesis.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Sarode GS,Sarode SC,Tupkari JV,Deshmukh R,Patil Sdoi
10.1016/j.mehy.2016.06.007subject
Has Abstractpub_date
2016-08-01 00:00:00pages
166-9eissn
0306-9877issn
1532-2777pii
S0306-9877(16)30221-3journal_volume
93pub_type
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