Could the high consumption of high glycaemic index carbohydrates and sugars, associated with the nutritional transition to the Western type of diet, be the common cause of the obesity epidemic and the worldwide increasing incidences of Type 1 and Type 2 d

abstract：:A new hypothesis is presented to explain some aspects of human smoking behaviour. While acknowledging the importance of the nicotine self-titration phenomenon, changes in puffing intensity during the smoking of a single cigarette are related not to the control of nicotine uptake but to the modification of cigarette sm...

journal_title：Medical hypotheses

authors： Chamberlain AT,Higenbottam TW

更新日期：1985-08-01 00:00:00

abstract：:In endemic pemphigus foliaceus (EPF) or "fogo selvagem" the epidemiological evidence shows that all the described outbreaks occur on the banks of rivers where there is mercury contamination from alluvium gold mining and deforestation. Pathophysiological evidence shows a similarity to pemphigus induced by sulphydryl (S...

journal_title：Medical hypotheses

authors： Robledo MA

更新日期：2012-01-01 00:00:00

abstract：:Concerning the damage to back muscles and posterior ligament complex (PLC) by posterior open approach for lumbar spinal stenosis (LSS), the oblique lateral intervertebral fusion (OLIF) is pretty popular nowadays. However, oblique lateral approach has obvious drawbacks, which are limited vision and operative scope for ...

journal_title：Medical hypotheses

authors： Du C,Wu T,Mao T,Jia F,Hai B,Zhu B,Liu X

更新日期：2020-11-01 00:00:00

abstract：:Treatment for stuttering attempts to reduce or eliminate the observable core markers of the disorder, specifically repetitions and prolongation. In this hypothesis, it is proposed that stuttering may be inhibited by two distinct yet related procedures: active inhibition and passive inhibition. Active inhibition is bro...

journal_title：Medical hypotheses

authors： Saltuklaroglu T,Dayalu VN,Kalinowski J

更新日期：2002-01-01 00:00:00

abstract：:Inflammatory eye diseases such as uveitis are common and may eventually result in vision loss. Iron can play a critical role in ocular inflammation via promoting the generation of oxygen free radicals and it is also nutritionally essential for microbial growth. Considering this involvement of iron in inflammation and ...

journal_title：Medical hypotheses

authors： Chen J,Zhou J,Kelly M,Holbein BE,Lehmann C

更新日期：2017-06-01 00:00:00

abstract：:COVID-19 due to the SARS-CoV-2 infection is a multi-systemic immune syndrome affecting mainly the lungs, oropharyngeal region, and other vascular endothelial beds. There are tremendous ongoing efforts for the aim of developing drugs against the COVID-19 syndrome-associated inflammation. However, currently no specific ...

journal_title：Medical hypotheses

authors： Beyazit F,Beyazit Y,Tanoglu A,Haznedaroglu IC

更新日期：2020-10-01 00:00:00

abstract：:In this work we propose a simple mathematical model for the analysis of the impact of control measures against an emerging infection, namely, the severe acute respiratory syndrome (SARS). The model provides a testable hypothesis by considering a dynamical equation for the contact parameter, which drops exponentially w...

journal_title：Medical hypotheses

authors： Massad E,Burattini MN,Lopez LF,Coutinho FA

更新日期：2005-01-01 00:00:00

abstract：:Although frequently encountered, no available consensus about the association between skeletal abnormalities and skin pigmentation. Several syndromes are characterized by the presence of skin pigmentation in association with skeletal disorders like neurofibroamtosis 1, McCune-Albright Syndrome, Jaffe-Campanacci Syndro...

journal_title：Medical hypotheses

authors： Abdel-Wanis ME,Kawahara N

更新日期：2003-11-01 00:00:00

abstract：:The presented hypothesis suggests that chronic latent malaria infection prepares the niche where the otherwise feeble HIV coinfection can thrive and cause AIDS. It is suggested that the roots of the HIV outbreak and AIDS pandemic lay in the urbanization processes in Africa that resulted in the eradication of the Anoph...

journal_title：Medical hypotheses

authors： Yaffe I

更新日期：2001-10-01 00:00:00

abstract：:Body size and body composition have been suggested as the best explanation for the temporal trend toward early menarche over the last 100 years. There is evidence from human and animal studies that indicates that body size is not the primary factor in influencing the occurrence of menarche. The data actually show that...

journal_title：Medical hypotheses

authors： Sanchez A,Kissinger DG,Phillips RI

更新日期：1981-11-01 00:00:00

abstract：:Host cholesterol is widely getting recognized as an important factor in the pathogenesis of tuberculosis in multiple ways. Therefore it is logically expected that cholesterol reduction by statins is going to have a positive outcome in the context of tuberculosis management. But at the present moment statin therapy in ...

journal_title：Medical hypotheses

authors： Banerjee D,Bhattacharyya R

更新日期：2014-07-01 00:00:00

abstract：:Epidemiological studies reveal that chronic alcoholics exhibiting liver disease are generally malnourished. Experimental studies unequivocally demonstrate that incidence of malnutrition cannot be avoided in animals fed liquid diets containing high concentrations of alcohol. Furthermore, ingestion of additional amounts...

journal_title：Medical hypotheses

authors： Sankaran H,Larkin EC,Rao GA

更新日期：1994-02-01 00:00:00

abstract：:The paper discusses a mechanism for reciprocal translocation of midsegments between two chromatids so that one of the segments is restacked in inverted configuration. Regarding malignant cells, such process could derive from anachronistic assembly of the nuclear envelope. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：1998-06-01 00:00:00

abstract：:Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin:light therapy is hypothesized to be mediated by superoxide. ...

journal_title：Medical hypotheses

authors： Peterson DA,McKelvey S,Edmondson PR

更新日期：1981-02-01 00:00:00

abstract：:Although peripartum cardiomyopathy (PPCM) is a rare disease, it has very serious consequences for both mother and child. No single cause has been held responsible for the pathogenesis. Recent studies have indicated that increased proteolytic cathepsin D activity in cardiomyocytes results in16kDa prolactin fragments wi...

journal_title：Medical hypotheses

authors： Reuwer AQ,Reuwer PJ,van der Post JA,Cramer MJ,Kastelein JJ,Twickler MT

更新日期：2010-02-01 00:00:00

abstract：:There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compare...

journal_title：Medical hypotheses

authors： Dahlen HG,Kennedy HP,Anderson CM,Bell AF,Clark A,Foureur M,Ohm JE,Shearman AM,Taylor JY,Wright ML,Downe S

更新日期：2013-05-01 00:00:00

abstract：:Autism is a pervasive developmental disorder that is characterized by the behavioral traits of impaired social cognition and communication, and repetitive and/or obsessive behavior and interests. Although there are many theories and speculations about the pathogenetic causes of autism, the disruption of the serotonerg...

journal_title：Medical hypotheses

authors： Sato K

更新日期：2013-04-01 00:00:00

abstract：:It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/H...

journal_title：Medical hypotheses

authors： Bhattacharyya D

更新日期：2020-11-01 00:00:00

abstract：:Ever since antimicrobial therapy was introduced, two phenomenons have been observed: drug resistance and host toxicity. Mutation(s) in microbes leads to the earlier, while off target effects of therapy cause the latter. Neither of these problems have yet to be resolved. All Microbes express specific antigens, against ...

journal_title：Medical hypotheses

authors： Singla M

更新日期：2007-01-01 00:00:00

abstract：:An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...

journal_title：Medical hypotheses

authors： Lin YP,Cheng TJ

更新日期：2002-08-01 00:00:00

abstract：:Trypanosoma cruzi is thought to selectively destroy the postganglionic cardiac vagal neurons of chagasic cardiac patients. This theory is based on morphologic and functional evidences obtained from chagasic individuals who were in very advanced stages of the disease. We have studied chagasic patients who were in both ...

journal_title：Medical hypotheses

authors： Davila DF,Donis JH,Torres A,Gottberg CF,Rossell O

更新日期：1991-06-01 00:00:00

abstract：:Based on a logic of balance mechanisms influencing information processing in tripartite synapses are proposed. It is hypothesized that the number of expressed astrocytic receptors determines balanced and imbalanced synaptic states. Synaptic information processing in mental disorders is underbalanced in depression, ove...

journal_title：Medical hypotheses

authors： Mitterauer BJ

更新日期：2015-04-01 00:00:00

abstract：:Multiple reports show the efficacious usage of ECT for catatonia in individuals with autism. There are also a few reports showing that ECT improves self-injury in people with and without autism. In this hypothesis, self-injury in autism and other developmental disorders may be an alternate sign of catatonia, and as su...

journal_title：Medical hypotheses

authors： Wachtel LE,Dhossche DM

更新日期：2010-07-01 00:00:00

abstract：:The persistent use of different forms of nicotine replacement therapy (NRT) is an under-investigated issue in medical research. While the data concerning the proportion of long-term users in the population of total NRT users seems reassuring at first glance, we must recognize that the small relative numbers (proportio...

journal_title：Medical hypotheses

authors： Dome P

更新日期：2011-12-01 00:00:00

abstract：:The amino acid threonine contains two chiral carbons and thus can exist in four possible conformations. However, only a single conformation (2S, 3R) of threonine is incorporated in proteins by the cellular translation material. The conformation at the alpha carbon (carbon 2) is the same as that of the other amino acid...

journal_title：Medical hypotheses

authors： Altschuler EL

更新日期：2001-04-01 00:00:00

abstract：:Sudden cardiac death prematurely claims the lives of some 7 million each year worldwide. It occurs primarily in patients with an underlying structural cardiac abnormality, and regardless of the type of the underlying pathology (heart failure, dilated and hypertrophic cardiomyopathies, myocardial infarction and aging),...

journal_title：Medical hypotheses

authors： Sovari AA,Morita N,Weiss JN,Karagueuzian HS

更新日期：2008-08-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative condition characterized by tremor, rigidity, bradykinesia, and postural instability. Smoking is an inverse risk factor for Parkinson's disease, although the mechanism for this apparent neuroprotection is not definitively established. Smoking consistently upregulates nicotinic...

journal_title：Medical hypotheses

authors： Chapman MA

更新日期：2009-12-01 00:00:00

abstract：:The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The re...

journal_title：Medical hypotheses

authors： Oliveira DBG

更新日期：2018-03-01 00:00:00

abstract：:Glaucoma is the leading cause of irreversible blindness worldwide, which is now viewed as a disease of brain with pathogenesis not fully understood. The main diagnostic methods are examining the retinal nerve fiber layer through optical coherence tomography and investigating visual field defect, but these methods pres...

journal_title：Medical hypotheses

authors： Sun Y,Huang W,Li F,Li H,Wang L,Huang Y,Zhang X

更新日期：2019-02-01 00:00:00

abstract：:Parkinson's disease is one of the mostly seen neurological disease. It affects to nervous system and hinders people's vital activities. The majority of Parkinson's patients lose their ability to speak, write and balance. Many machine learning methods have been proposed to automatically diagnose Parkinson's disease usi...

journal_title：Medical hypotheses

authors： Yaman O,Ertam F,Tuncer T

更新日期：2020-02-01 00:00:00