Alpha helix capping and the conformation of threonine.

abstract：:Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative diseases of oral mucosa affecting an estimate of 20% of the world's population. Majority of the people affected by RAS are under 30 years of age. RAS is located on the lining (non-keratinized) oral mucosa, i.e. buccal mucosa, lateral side of the tongue,...

journal_title：Medical hypotheses

authors： Pärssinen M,Jäsberg H,Mikkonen JJW,Kullaa AM

更新日期：2021-01-01 00:00:00

abstract：:Chronic Fatigue Syndrome is a physiological state in which the patient feels high levels of fatigue without an obvious organic cause, which affects around 1 in 400 people in the developed world. A wide range of causes have been suggested, including immune or hormonal dysfunction, viral or bacterial infection, and psyc...

journal_title：Medical hypotheses

authors： Bains W

更新日期：2008-10-01 00:00:00

abstract：:The Sudden Infant Death Syndrome (SIDS) is responsible for the death of 10,000 infants annually in the U.S.A. The cause of these deaths is not known; all SIDS infants studied died during sleep in a silent fashion and there are no specific lesions observable post mortem. It may be of significance, however, that nearly ...

journal_title：Medical hypotheses

authors： Reid GM

更新日期：1987-03-01 00:00:00

abstract：:Damaged DNA can lead to aneuploidy and/or chromosomal instability, which is believed to be major contributor to tumor progression. Genotoxic and oncogenic stresses-induced DNA damage activate the tumor suppressor pathways initiate DNA damage response (DDR). One of the cellular fates in response to DDR is permanent gro...

journal_title：Medical hypotheses

authors： Erol A

更新日期：2010-06-01 00:00:00

abstract：:Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand fo...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2001-02-01 00:00:00

abstract：:Endothelial dysfunction due to reduced bioavailability of nitric oxide (NO) is an early step in the course of atherosclerotic cardiovascular disease (CVD). NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as asymmetric dimethyla...

journal_title：Medical hypotheses

authors： Yamagishi S,Ueda S,Okuda S

更新日期：2007-01-01 00:00:00

abstract：:In addition to classical metastatic pathways, recently gastric cancer was described having an alternative route called "endoluminal exfoliation". Provisional analyses demonstrated, in fact, this kind of shedding is associated with several clinico-pathological features indicative of aggressive behavior and resulted to ...

journal_title：Medical hypotheses

authors： Virgilio E,Balducci G,Mercantini P,Giarnieri E,Giovagnoli MR,Montagnini M,Proietti A,D'Urso R,Cavallini M

更新日期：2018-05-01 00:00:00

abstract：:Chimeras are the result of fusion of two zygotes to form a single embryo, producing an individual with genetically different kinds of tissue. If the fused zygotes are of different sex, the individual develops both ovarian and testicular tissues. The majority of these people are best reared as females and many pregnanc...

journal_title：Medical hypotheses

authors： Irmak MK

更新日期：2010-11-01 00:00:00

abstract：:Rushton bodies (RBs) are one of the characteristic features seen in the epithelial lining of odontogenic cysts mainly radicular, dentigerous and odontogenic keratocyst. It has two different histo-morphological appearances; granular and homogeneous. Although widely investigated, the exact pathogenesis and histogenesis ...

journal_title：Medical hypotheses

authors： Sarode GS,Sarode SC,Tupkari JV,Deshmukh R,Patil S

更新日期：2016-08-01 00:00:00

abstract：:The dominant role of the physical and chemical environment in the development of cancer is challenged. Analyses of the etiology of skin, bladder, respiratory and gastric cancers are presented which demonstrate the considerable extent to which one's health status may modify the initiation and promotion of environmental...

journal_title：Medical hypotheses

authors： Calabrese EJ

更新日期：1979-01-01 00:00:00

abstract：:Preliminary reports have suggested that chronic, intermittent electrical stimulation of the cervical vagus nerve (VNS) is an effective treatment for patients who suffered from medically refractory epilepsy. But the traditional VNS is an invasive and implantable procedure that will bring some injury to the patient. Ana...

journal_title：Medical hypotheses

authors： Yang AC,Zhang JG,Rong PJ,Liu HG,Chen N,Zhu B

更新日期：2011-08-01 00:00:00

abstract：:All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. In this paper, I propose a dynamic model of how tumor cells escape the supervision of the immune system; I also examine the possibil...

journal_title：Medical hypotheses

authors： Cai DW

更新日期：1995-05-01 00:00:00

abstract：:Over-proliferation of SMC (smooth muscle cell) is one characteristics of atherosclerosis. One well accepted mechanism is that the decrease of ECs (endothelial cells) induced by over apoptosis leads to endothelial dysfunction, which in turn results in over-proliferation of SMC. Obviously, the mechanism works after endo...

journal_title：Medical hypotheses

authors： Qin C,Liu Z

更新日期：2007-01-01 00:00:00

abstract：:The major thesis of the proposed hypothesis is that in the absence of microbial material synovial macrophages in rheumatoid arthritis patients continue to release interleukin 1, which perpetuates the inflammation so characteristic of the disease. Its release is suggested to result from an altered synovial macrophage g...

journal_title：Medical hypotheses

authors： Rafter GW

更新日期：1982-10-01 00:00:00

abstract：:Hypotheses regarding the factors that predispose individuals to developing AIDS after exposure to HTLV-III/LAV are beginning to emerge. It is suggested here that surgical removal of tonsils in childhood may increase the risk of developing opportunistic infections after infection with this newly discovered retrovirus. ...

journal_title：Medical hypotheses

authors： McCombie SC

更新日期：1986-03-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play an essential role in tumor-associated immunosuppression, which hampers effective immunotherapeutic approaches. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate target gene expression at the posttranscriptional level...

journal_title：Medical hypotheses

authors： Tian J,Rui K,Wang S

更新日期：2014-08-01 00:00:00

abstract：:At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Give...

journal_title：Medical hypotheses

authors： Tao H,Ge G,Li W,Liang X,Wang H,Li N,Sun H,Zhang W,Geng D

更新日期：2020-12-01 00:00:00

abstract：:Diabetes is a global public health challenge that imposes heavy burdens on communities and individuals. Metformin, the first-line medication for diabetes, has the superiority of reducing risk of macrovascular diseases, all-cause mortality and even possibly cancers. Recent observational studies, however, have demonstra...

journal_title：Medical hypotheses

authors： Xu L,Huang Z,He X,Wan X,Fang D,Li Y

更新日期：2013-08-01 00:00:00

abstract：:The "small-for-size" syndrome and "post-hepatectomy liver failure" refers to the development of liver failure (hyperbilirubinemia, coagulopathy, encephalopathy and refractory ascites) resulting from the reduction of liver mass beyond a certain threshold. This complication is associated with a high mortality and is a m...

journal_title：Medical hypotheses

authors： Asencio JM,Vaquero J,Olmedilla L,García Sabrido JL

更新日期：2013-05-01 00:00:00

abstract：:Obstructive sleep apnea is characterized by episodes of intermittent hypoxia that occur while the afflicted person sleeps, and is believed to affect and have a negative impact on many people worldwide. Both observational evidence in obstructive sleep apnea patients and direct studies in mice mimicking the disease stro...

journal_title：Medical hypotheses

authors： Johnson PR

更新日期：2008-10-01 00:00:00

abstract：:Chronic otitis media with cholesteatoma can cause erosion of the dense labyrinthine bone overlying the inner ear organs, and this labyrinthine fistula allows pressure or mass-induced motion of the underlying perilymphatic and endolymphatic compartment, evoking vestibular symptoms. While the mechanism of a positive fis...

journal_title：Medical hypotheses

authors： Jeong H,Lee DH,Shin JE,Kim CH

更新日期：2020-11-01 00:00:00

abstract：:The present paper hypothesizes that the top positions in academic medicine are generally occupied by less talented and skilled physicians who find more time to spare for administrative activities as compared to physicians who are successful in their research projects or enjoy their skills as practicing clinicians. A p...

journal_title：Medical hypotheses

authors： Sonnenberg A

更新日期：2007-01-01 00:00:00

abstract：:A localized graft-versus-host reaction was used to assess the cellular immunity of mice supporting progressive growth of an allogeneic tumor. It was found that early in tumor development anti-tumor-cellular-mediated immunity was hyper-responsive, and that adherent phagocytic cells isolated from the neoplasm would inhi...

journal_title：Medical hypotheses

authors： Parks RC

更新日期：1979-09-01 00:00:00

abstract：:The various neurotransmitter systems postulated to be involved in the pathogenesis of Gilles de la Tourette syndrome(GTS) are described with special reference to the endogenous opioid system(EOS). Malfunction of the opioid system is proposed as the underlying disturbance in this disease causing secondary dysfunction o...

journal_title：Medical hypotheses

authors： Gillman MA,Sandyk R

更新日期：1986-04-01 00:00:00

abstract：:The staggering number of publications featuring the use of stem cells has revolutionized regenerative medicine research. Preclinical studies indicate that allogeneic human mesenchymal stem cells (MSCs) may be useful for the treatment of several clinical disorders, including sepsis, acute renal failure, acute myocardia...

journal_title：Medical hypotheses

authors： Mamidi MK,Pal R,Govindasamy V,Zakaria Z,Bhonde R

更新日期：2011-04-01 00:00:00

abstract：:Atherosclerosis and its fatal complications, such as myocardial infarction or stroke, represent the most common cause of morbidity or mortality in modern world. It was observed that an excess of reactive oxygen species (ROS) accompanies atherosclerosis. Under physiological circumstances, intracellular H+ accumulates a...

journal_title：Medical hypotheses

authors： Zheng Z,Zhang Z,Wang M

更新日期：2020-08-01 00:00:00

abstract：:The disturbances of the 11p15.5 chromosomal region are associated with Beckwith-Wiedemann syndrome, Russell-Silver syndrome, Wilms tumor, IMAGe syndrome, and idiopathic hemihyperplasia. The aim of this research was to examine the hypothesis that 11p15.5 initially became unstable in the European population about 200 ye...

journal_title：Medical hypotheses

authors： Shterenshis M,Roitblat Y,Ilani J,Lumbroso J,Padilla-Raygoza N

更新日期：2018-12-01 00:00:00

abstract：:The two-stage initiation-progression model of cancer is widely accepted. Initiation appears to result most often from accumulation of damage to the DNA expressed as multiple mutations in the phenotype. Unsymmetrical chromosome segregation during mitosis of normal or mutated cells produces aneuploid cells and also cont...

journal_title：Medical hypotheses

authors： Parris G

更新日期：2006-01-01 00:00:00

abstract：:Despite the fact that antidepressants represent the gold standard for the treatment of depression, not all patients treated with an antidepressant monotherapy achieve complete remission of depressive symptoms and functional recovery. Therefore, further examination of the components that may be involved in the action m...

journal_title：Medical hypotheses

authors： Pae CU,Lee C,Paik IH

更新日期：2007-01-01 00:00:00

abstract：:The origin and initiating features of PBC remain obscure despite decades of study. However, recent papers have demonstrated loss of canals of Hering (CoH) to be the earliest histologic change in liver biopsy specimens from patients with primary biliary cholangitis (PBC). We posit that CoH loss prior to significant inf...

journal_title：Medical hypotheses

authors： Theise ND,Crawford JM,Nakanuma Y,Quaglia A

更新日期：2020-03-16 00:00:00