Abstract:
:The staggering number of publications featuring the use of stem cells has revolutionized regenerative medicine research. Preclinical studies indicate that allogeneic human mesenchymal stem cells (MSCs) may be useful for the treatment of several clinical disorders, including sepsis, acute renal failure, acute myocardial infarction, and more recently, acute lung injury (ALI). However, considerable success would not be obtained in clinical trials due to poor survival of transplanted cells under the influence of inflammatory conditions. Despite robust approaches like cellular reprogramming, scaffolds and conditioned media have been tested to overcome this problem; however the success rate of these approaches remain questionable. Recently, pretreatment of bioactive compounds in vitro have been shown to suppress cell apoptosis and promote cell survival. Quite likely a similar phenomenon can take place in vivo. Based on such studies, we hypothesize that MSCs derived from human post-natal tissues could be conditioned and prepared for targeted disease therapy. Depending on the disease condition, the MSCs could be treated prior to delivery with appropriate bioactive compounds to allow them survive longer and perform a better role as biocatalyst. The advantage of this approach could be the tailor made availability of MSCs preconditioned with appropriate bioactive compounds for disease specific therapy. Therefore, the choice of suitable bioactive molecule is likely to enhance the efficacy of targeted stem cell therapy and preconditioning may provide a novel strategy in maximizing biological and functional properties of MSCs.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Mamidi MK,Pal R,Govindasamy V,Zakaria Z,Bhonde Rdoi
10.1016/j.mehy.2011.01.010subject
Has Abstractpub_date
2011-04-01 00:00:00pages
599-601issue
4eissn
0306-9877issn
1532-2777pii
S0306-9877(11)00011-9journal_volume
76pub_type
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90046-f
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
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更新日期:2018-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.01.024
更新日期:2009-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.05.037
更新日期:2017-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0878
更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mehy.2006.08.041
更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.09.022
更新日期:2010-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 临床试验,杂志文章
doi:10.1016/0306-9877(82)90089-5
更新日期:1982-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.11.001
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109614
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.04.065
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2003.12.028
更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90299-6
更新日期:1995-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.06.021
更新日期:2018-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90040-2
更新日期:1997-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2015.05.012
更新日期:2015-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.09.013
更新日期:2016-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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