Abstract:
:Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of Vitamin K on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of Vitamin K overlap with key brain development aberrations, including those associated with autism. Furthermore, Vitamin K protects against oxidative stress associated with toxic exposure. Research on the neural effects is reviewed, and a small sample of severely autistic children of Somali descent residing in the Minneapolis/St. Paul area of Minnesota were genotyped and found to have a higher than expected genetic substitution that results in reduction in the efficiency of the Vitamin K cycle. The possibility that this genetic difference could play an etiological role in the development of autism is considered.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
DeSoto MCdoi
10.1016/j.mehy.2016.09.013subject
Has Abstractpub_date
2016-11-01 00:00:00pages
30-33eissn
0306-9877issn
1532-2777pii
S0306-9877(16)30617-Xjournal_volume
96pub_type
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journal_title:Medical hypotheses
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