Abstract:
:Rheumatoid arthritis is complex and not clear on the mechanism of pathogenesis. On the basis of analysis of the symptom and pathology of rheumatoid arthritis patients, we raised a new hypothesis. The content of the hypothesis is as follows: (A) Collagen II or collagen II-Iike substance in human cartilage is the cross-autoantigen of some infecting virus or bacteria because of the structure's similarity. (B) The inflammation in synovial tissue is auto-immunoreaction to collagen II in cartilage. (C) The proliferation and attachment of synovial tissue to the surface of cartilage is due to the chemotaxis of collagen II in cartilage for the immunocytes in synovial tissue. (D) The collagenase secreted from synovial cells and immunocytes are the direct elements in the destruction of cartilage. The fallen collagen II from cartilage is one of the most important inducer on the synovial cells and immunocytes for the production of collagenase.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Wang J,Liu X,Li F,Yao Ldoi
10.1016/s0306-9877(02)00143-3keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
411-5issue
4eissn
0306-9877issn
1532-2777pii
S0306987702001433journal_volume
59pub_type
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