Abstract:
:The results described in this paper partially agree with the hypothesis that mesenteric lymph nodes (MLN) of depleted growing rats recover their antigen specific determinants after the oral administration of 20% casein for 5-9 days following the time course of antigen dependent changes observed in virgin lymph nodes. With respect to the 39 days old control group, depleted MLN showed a highly diminished number of mature T cells (W3/13+) as well as surface and intracellular alpha heavy chain (alpha s and alpha cit). The oral administration of a 20% casein diet during 5 days tends to restore the appearance of these determinants; however, normal values were not attained even if refeeding was continued for 9 days. The discrepancy between the proposed hypothesis and the observed results might be ascribed to: a) defective migration of T cells from thymus; b) the diminished number of TH cells involved in terminal differentiation; c) inability of B cells to respond to T cell-derived factors.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Langini SH,López MC,Slobodianik NH,Sanahuja JC,Rio ME,Roux MEdoi
10.1016/0306-9877(87)90058-2subject
Has Abstractpub_date
1987-08-01 00:00:00pages
375-81issue
4eissn
0306-9877issn
1532-2777pii
0306-9877(87)90058-2journal_volume
23pub_type
杂志文章abstract::It is proposed that there is biological regulation of the low molecular weight antioxidant (LMWA) status of the body, and that these different antioxidants work in concert and in homeostasis as a system analogous to the regulation of acid-base status (pH). The theoretical design characteristics for such a system inclu...
journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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更新日期:2008-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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