Abstract：
:Obesity is a major public health problem, which occurs in epidemic proportions. Our understanding of the systems of the brain related to energy balance has increased over the last decade. As a result, drugs most commonly used today in the management of obesity have their primary effect in modulating the balance between monoaminergic neurotransmitters, among other serotonin. Serotonin is believed to be involved in the complex process of integrating physiological and behavioral systems geared towards energy balance. However, gradual weight gain seen in most people suggests that the regulatory system may not be sufficient under all circumstances. An insufficient serotoninergic neuronal function in the central nervous system has been shown in many studies to occur in patents with depression. In such serotonin-deficient patients, treatment with drugs increasing the concentration of serotonin at serotoninergic synapses gives a favorable clinical response. Taken together, this suggests to a certain extent a common pathophysiology between obesity and depression. Literature spanning several decades has addressed the relationship among obesity and depression. However, obesity and depression research have evolved as two independent disciplines, which rarely or never overlap. In this paper, we propose the notion that obesity and depression may represent different manifestations of the same disease process - Janus faces of the modern society.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Rosmond Rdoi
10.1016/j.mehy.2003.12.030keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
976-9issue
6eissn
0306-9877issn
1532-2777pii
S0306987704000660journal_volume
62pub_type
杂志文章abstract：:The present analysis addresses the question of how it has been possible for academic medicine to grow and lose its creative productivity at the same time. A mathematical model is developed to simulate the mechanisms that govern growth of medical systems over time. Time-dependent growth of system size increases the occ...
journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
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pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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journal_title：Medical hypotheses
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doi：10.1016/j.mehy.2010.08.047
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doi：10.1016/0306-9877(86)90036-8
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pub_type： 杂志文章
doi：10.1016/j.mehy.2010.08.039
更新日期：2011-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 社论
doi：10.1016/j.mehy.2007.07.006
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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