Abstract:
:An observation of sleep improvement with vitamin D supplementation led to a 2 year uncontrolled trial of vitamin D supplementation in 1500 patients with neurologic complaints who also had evidence of abnormal sleep. Most patients had improvement in neurologic symptoms and sleep but only through maintaining a narrow range of 25(OH) vitamin D3 blood levels of 60-80 ng/ml. Comparisons of brain regions associated with sleep-wake regulation and vitamin D target neurons in the diencephalon and several brainstem nuclei suggest direct central effects of vitamin D on sleep. We propose the hypothesis that sleep disorders have become epidemic because of widespread vitamin D deficiency. The therapeutic effects together with the anatomic-functional correspondence warrant further investigation and consideration of vitamin D in the etiology and therapy of sleep disorders.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Gominak SC,Stumpf WEdoi
10.1016/j.mehy.2012.03.031subject
Has Abstractpub_date
2012-08-01 00:00:00pages
132-5issue
2eissn
0306-9877issn
1532-2777pii
S0306-9877(12)00150-8journal_volume
79pub_type
杂志文章abstract::Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe), manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium (Ca) - have been observed in the foodchains that traditionally support the Chamorro populations affected by high incidence clusters of Alzheimer (AD), Parkinson-like ...
journal_title:Medical hypotheses
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 社论,历史文章,评审
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journal_title:Medical hypotheses
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pub_type: 信件
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.mehy.2012.01.033
更新日期:2012-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
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