Abstract：
:Trypanosomiasis (whether African sleeping sickness, or American Chaga's disease) is caused by an infection with a protozoan parasite, i.e. the trypanosome. This carries fatal sequences in the untreated host. Currently available chemotherapeutic drugs (some of which cure by involving reactive oxygen species (ROS] are not optimally adequate. They are toxic as well, and may also be carcinogenic. It is therefore desirable to devise better chemotherapeutic regimens. ROS destroy the parasite, but excess ROS damage host tissue and are potentially carcinogenic. Alpha-difluoromethylornithine (DFMO) inhibits ornithine decarboxylase and so lowers the levels of spermine and spermidine. This singular effect in the parasite inhibits its multiplication, whereas in the host tissue it prevents carcinogenesis by preventing cell proliferation. Thus, combination of ROS-generating drugs with DFMO would be very effective against trypanosomiasis, and would be without cancer risk too. The combination is therefore advocated for chemotherapy of trypanosoma infections. This necessities experimental investigations specifically directed towards establishing the optimally efficacious combination of DFMO with the drugs.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Eze MOdoi
10.1016/0306-9877(91)90142-lsubject
Has Abstractpub_date
1991-11-01 00:00:00pages
246-9issue
3eissn
0306-9877issn
1532-2777pii
0306-9877(91)90142-Ljournal_volume
36pub_type
杂志文章abstract：:The Sudden Infant Death Syndrome (SIDS) is responsible for the death of 10,000 infants annually in the U.S.A. The cause of these deaths is not known; all SIDS infants studied died during sleep in a silent fashion and there are no specific lesions observable post mortem. It may be of significance, however, that nearly ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(87)90195-2
更新日期：1987-03-01 00:00:00
abstract：:Memory is a complex cognition that plays a critical role in daily functioning. This review discusses the dynamic effects of acute exercise on memory function, via a hypothesized exercise-memory interaction model, taking into consideration multiple memory systems and exercise parameters. ...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2019.03.010
更新日期：2019-05-01 00:00:00
abstract：:Neutrophils are activated in the coronary circulation during acute coronary events (unstable angina and myocardial infarction), often prior to the onset of ischemic damage. Moreover, neutrophils infiltrate coronary plaque in these circumstances, and may contribute to the rupture or erosion of this plaque, triggering t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.03.040
更新日期：2004-01-01 00:00:00
abstract：:The precise role of erythrophagocytosis in sickle cell disease is not known. Using hematological data from three studies and 791 subjects comprising of eight epidemiological groups, we found a strong statistical support for the hypothesis that erythrophagocytosis is increased in sickle cell trait, that neutrophils and...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.09.044
更新日期：2007-01-01 00:00:00
abstract：:An immune modulation complex is proposed which recognizes and is driven by an MHC presented epitope of the CD4 molecule present on the surface of up regulated CD4+ lymphocytes. Immune modulation is affected by both CD4 lymphocyte destruction and impairment of their potential for immune recognition. These two processes...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90123-8
更新日期：1993-11-01 00:00:00
abstract：:In an effort to develop a method to ascertain whether ancient physicians used certain drugs because of their efficacy or for other reasons (random process, tradition, etc.), the authors have devised a statistical test (Efficacy Quotient-EQ) to evaluate ancient therapeutic data quantitatively. They have applied the Eff...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/s0306-9877(98)90057-3
更新日期：1998-10-01 00:00:00
abstract：:Studies on receptor stability suggest that functional conversion of adrenoceptors between alpha and beta can occur in mammalian myocardium due to variations in the environment such as temperature changes, pH or hormonal changes. If adrenoceptors of the respiratory system behave similarly, heat and water loss of airway...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(88)90011-4
更新日期：1988-12-01 00:00:00
abstract：:Benign prostatic hyperplasia (BPH) is one of the most common problems faced by aging men and can be associated with bothersome lower urinary tract symptoms that affect quality of life by interfering with normal daily activities and sleep patterns. Despite the clinical importance of BPH, its pathogenesis is still poorl...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.07.012
更新日期：2008-01-01 00:00:00
abstract：:The accumulation of fibrin/fibrinogen and other coagulation factors in and around solid tumors and metastatic foci has been recognized for a century as an aspect of cancer pathology. On this basis, anticoagulants and fibrinolytic agents have been deployed as adjuvant anticancer therapies, but they have proved clinical...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.06.045
更新日期：2007-01-01 00:00:00
abstract：:SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatm...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109843
更新日期：2020-10-01 00:00:00
abstract：:Cannabis use has often been associated with various forms of psychosis. Today it is well established that everyone produces marijuana-like compounds known as endocannabinoids. The endocannabinoid system is a homeostatic regulator of all body systems including the nervous system. As a result, imbalances in the endocann...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.08.025
更新日期：2009-02-01 00:00:00
abstract：:For a number of years, the principal attention was accorded total serum cholesterol as a possible predictor of cardiovascular pathosis. More recently, emphasis has been shifted to the high-density lipoproteins (HDL). Now consideration is turning to the ratio of total serum cholesterol to high-density lipoproteins. In ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(82)90057-3
更新日期：1982-12-01 00:00:00
abstract：:High doses of oestrogens in the dog and ferret cause myeloid hyperplasia in the bone marrow superseded by hypoplasia affecting all cell lines. In the peripheral blood after an initial leucocytosis, there is thrombocytopenia, anaemia and leucopenia. These effects, which are ultimately lethal, do not occur in cats, rats...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(85)90070-2
更新日期：1985-02-01 00:00:00
abstract：:Atherosclerosis is a common disease whose complications, such as myocardial infarction, are a leading cause of mortality worldwide. Therefore, ideas which try to explain the circumstances of atherosclerotic plaque initiation and progression are warranted. We hypothesize that low-grade inflammation in early life (espec...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.10.026
更新日期：2019-01-01 00:00:00
abstract：:Non-invasive molecular analysis of fetal DNA is the diagnostic goal of prenatal medicine. Circulating fetal DNA can be detected in maternal plasma. Recently, it has been detected in the urine of pregnant women. We hypothesize that fetal DNA is present also in maternal saliva and that advances in stabilization and isol...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.09.022
更新日期：2010-02-01 00:00:00
abstract：:Rodent studies reveal that oxidative stress, much of it generated via induction/activation of NADPH oxidase, is a key mediator of a number of the pathogenic effects of chronic ethanol overconsumption. The highly reactive ethanol metabolite acetaldehyde is a key driver of this oxidative stress, and doubtless works in o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.12.040
更新日期：2013-04-01 00:00:00
abstract：:The hypothesis is proposed that: 1. Aflatoxin B1 and polycyclic hydrocarbon carcinogens bind to the regions of DNA to which steroid hormones bind and cause the deletion of genes in these regions. 2. The deletion of these genes may be responsible for a reduced number of ribosomes bound to the endoplasmic reticulum. 3. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(77)90063-9
更新日期：1977-07-01 00:00:00
abstract：:The type of treatment that most psychiatric disturbances receive at present is a mixture of pharmacotherapy and psychotherapy, following the principle that mental functions are the result of the activities of brain machinery subsequent to the interaction between individuals and their external environment. We now know ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0774
更新日期：1999-01-01 00:00:00
abstract：:Hepatopulmonary syndrome (HPS) is a severe pulmonary sequela which can affect up to 15% of patients with cirrhotic liver disease. There is no treatment for HPS other than liver transplantation. The cause of HPS is incompletely understood, but the pulmonary vasodilation in HPS is thought to be related to increased leve...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.10.017
更新日期：2004-01-01 00:00:00
abstract：:The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with oth...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00013-6
更新日期：2003-04-01 00:00:00
abstract：:Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.01.026
更新日期：2005-01-01 00:00:00
abstract：:In this paper I hypothesize that a woman through her vagina absorbs sufficient quantities of the prostaglandins from her partner's semen, to affect her mood. The vagina appears to have an active transport mechanism which readily absorbs the hormones found in seminal plasma. The seminal secretions include estrogens, F....
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90128-3
更新日期：1986-06-01 00:00:00
abstract：:Mandibular asymmetry (MA) is one of the most common craniofacial malformations. However, there is no optimal technique for this malformation nowadays. A novel technique for both children and adults with less disadvantages is a must. Parathyroid hormone (PTH) is a straight-chain polypeptide secreted by the parathyroid ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.10.047
更新日期：2010-04-01 00:00:00
abstract：:Injury and organ failure after irradiation of late-responding tissues is a substantial problem in radiation oncology and a major threat after accidental or belligerent exposures. The mechanisms of injury may include death of clonogens, vascular injury, activation of cytokine networks, and/or chronic oxidative stress. ...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2012.11.022
更新日期：2013-02-01 00:00:00
abstract：:Open-angle glaucoma, idiopathic intracranial hypertension, and Meniere's disease are disorders managed by different specialties in medicine viz. ophthalmology, neurology, and otorhinolaryngology respectively. By working in silos, the similarity of these disorders is overlooked. Close inspection of these disorders reve...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109361
更新日期：2019-11-01 00:00:00
abstract：:In addition to classical metastatic pathways, recently gastric cancer was described having an alternative route called "endoluminal exfoliation". Provisional analyses demonstrated, in fact, this kind of shedding is associated with several clinico-pathological features indicative of aggressive behavior and resulted to ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.02.023
更新日期：2018-05-01 00:00:00
abstract：:Hypotheses generally conform to paradigms which, over time, change, usually tardily, after they have become increasingly difficult to sustain under the impact of non-conforming evidence and alternative hypotheses, but more important, when they no longer are comfortably ensconced in the surrounding social-economic-poli...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.07.030
更新日期：2006-01-01 00:00:00
abstract：:Recent findings indicate a principal role for Hepcidin in iron homeostasis. Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease. Under normal conditions influx and efflux of iron from duodenal enterocytes is regulated by Ferroportin. Fer...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.10.007
更新日期：2008-01-01 00:00:00
abstract：:Several experiments show that there is a cell to cell communication by light in different cell types. This article describes theoretical mechanisms and subcellular structures that could be involved in this phenomenon. Special consideration is given to the nervous system, since it would have excellent conditions for su...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/S0306-9877(03)00308-6
更新日期：2004-01-01 00:00:00
abstract：:The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109754
更新日期：2020-09-01 00:00:00
