当前位置： SCI文献检索 > MEDICAL HYPOTHESES期刊下所有文献 > Intra-articular injection of parathyroid hormone in the temporomandibular joint as a novel therapy for mandibular asymmetry.

Intra-articular injection of parathyroid hormone in the temporomandibular joint as a novel therapy for mandibular asymmetry.

Abstract：

:Mandibular asymmetry (MA) is one of the most common craniofacial malformations. However, there is no optimal technique for this malformation nowadays. A novel technique for both children and adults with less disadvantages is a must. Parathyroid hormone (PTH) is a straight-chain polypeptide secreted by the parathyroid gland that regulates calcium metabolism. PTH has both anabolic and catabolic effects on bone formation, depending on its mode of administration. Furthermore, the mandible is characterized by the most delayed growth and the most postnatal growth of all the facial bones. The condyle, the major growth site of mandible, grows by proliferation of cartilage in the condylar head and endochondral bone formation. Condylar cartilage is present throughout postnatal life, taking part in endochondral ossification and having a special multidirectional capacity for growth potential and remodeling throughout life. Based on the double effects of PTH on bone formation and characters of mandibular development and growth, it is hypothesized that intermittent or/and continuous intra-articular injection of PTH in the temporomandibular joint be a novel therapy for mandibular asymmetry for both children and adults. It can achieve early treatment of MA to avoid many secondary deformities and keep away from many complications resulting from current techniques or systematic administration of PTH.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Wan Q,Li ZB

doi

10.1016/j.mehy.2009.10.047

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

685-7

issue

4

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(09)00726-9

journal_volume

74

pub_type

杂志文章

相关文献

MEDICAL HYPOTHESES文献大全
  • Minocycline may be useful to prevent/treat postoperative cognitive decline in elderly patients.

    abstract：:Postoperative cognitive dysfunction (POCD) is reported to occur frequently after all types especially cardiac surgery in elderly patients. It can be short-term or long-term and some cases even develop into Alzheimer's disease (AD). Although multi-risk factors associated with POCD have been identified, the etiology and...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2011.02.010

    authors： Fan L,Wang TL,Xu YC,Ma YH,Ye WG

    更新日期：2011-05-01 00:00:00

  • For ischemic brain damage, is preclinical evidence of neuroprotection by presynaptic blockade of glutamate release enough?

    abstract：:Some drugs blocking glutamate release produce reduced brain injury in some animal models of cerebral ischemia whereas others lack a clear effect. Meta-analysis is a widely used technique in clinical and epidemiological studies. However, it has never been used in the analysis of preclinical studies. In order to estimat...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1054/mehy.1998.0831

    authors： Nava-Ocampo AA,Reyes-Pérez H,Bello-Ramírez AM,Mansilla-Olivares A,Ponce-Monter H

    更新日期：2000-01-01 00:00:00

  • Each type of cause that initiates rheumatoid arthritis or RA flares differentially affects the response to therapy.

    abstract：:The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2011.10.006

    authors： Molnar-Kimber KL,Kimber CT

    更新日期：2012-01-01 00:00:00

  • Meiotic dynamics in mammalian seminal cells.

    abstract：:The paper discusses certain dynamic processes leading to meiotic (haploid) partition of chromatids via the chiasmatic mode in mammalian spermatic cells. The achiasmatic case is also reviewed briefly and only in the context of homologs with centromeric braids arrayed in the Para configuration. ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(94)90013-2

    authors： Matioli GT

    更新日期：1994-12-01 00:00:00

  • Malignancy may contribute to rapid evolution.

    abstract：:Characteristics of malignant tumors, including anaerobic metabolism and metastases to lung, liver, bone and brain, may permit the enhanced survival of edited parts of the genome during periods of rapid environmental change. Carcinogenesis may be partially analogous to fossilization. ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(89)90150-3

    authors： Fischer K

    更新日期：1989-01-01 00:00:00

  • Vitamin D status modulates the immune response to Epstein Barr virus: Synergistic effect of risk factors in multiple sclerosis.

    abstract：:MS risk is associated with low vitamin D status prior to disease, and Epstein Barr virus (EBV) infection seems to be a prerequisite for MS. EBV could activate autoreactive T cells by several mechanisms, but it is not clear why this leads to MS. Only a small proportion of those infected with EBV develops MS, whereas au...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2007.04.030

    authors： Holmøy T

    更新日期：2008-01-01 00:00:00

  • Three-dimensional kinematic stress magnetic resonance image analysis shows promise for detecting altered anatomical relationships of tissues in the cervical spine associated with painful radiculopathy.

    abstract：:For some patients with radiculopathy a source of nerve root compression cannot be identified despite positive electromyography (EMG) evidence. This discrepancy hampers the effective clinical management for these individuals. Although it has been well-established that tissues in the cervical spine move in a three-dimen...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2013.07.043

    authors： Jaumard NV,Udupa JK,Siegler S,Schuster JM,Hilibrand AS,Hirsch BE,Borthakur A,Winkelstein BA

    更新日期：2013-10-01 00:00:00

  • Platelet hyperactivity in COVID-19: Can the tomato extract Fruitflow® be used as an antiplatelet regime?

    abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the impact of COVID-19 on neurological and haemostatic systems becomes mor...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2020.110480

    authors： O'Kennedy N,Duttaroy AK

    更新日期：2021-01-04 00:00:00

  • Gastric carcinoma promoted by alkaline reflux gastritis -- with special reference to bile and other surfactants as promoters of postoperative gastric cancer.

    abstract：:For reasons that are not known, the incidence of stomach cancer is declining in most countries. In contrast, cancer of the gastric remnant after partial gastrectomy for peptic ulcer disease seems to be increasing. "Stump cancer" has been claimed to be a separate disease entity and has recently been mentioned as an iat...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(79)90112-9

    authors： Domellöf L

    更新日期：1979-04-01 00:00:00

  • Integrated electronic monitoring systems could revolutionize care for patients with cognitive impairment.

    abstract：:Dementia and other causes of functional disability can create considerable burdens for families and society as a whole, but it may be possible to partially alleviate this strain through technical innovations that replace some functions of human caregivers. This article proposes the hypothesis that cell phones, interne...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2005.11.045

    authors： Alisky JM

    更新日期：2006-01-01 00:00:00

  • The role of vitamin D3 in the aetiology of abdominal aortic aneurysms.

    abstract：:Abdominal aortic aneurysms (AAAs) have traditionally been attributed to atherosclerosis, although there is increasing epidemiological, biochemical and genetic evidence that aneurysmal arterial disease is different from occlusive atherosclerosis. One of the most consistent biochemical findings in the aneurysmal aorta i...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(95)90193-0

    authors： Norman PE,Wysocki SJ,Lamawansa MD

    更新日期：1995-07-01 00:00:00

  • Intra-monocyte pathogens delineate autism subgroups.

    abstract：:Immune panels of many autism-spectrum children reveal signs of atypical infections and shifted cell counts. In conjunction with trait-related cerebral hypometabolism and hypoperfusion, these findings suggest a hypothesis: Several autism-spectrum subgroups derive from intra-monocyte pathogens such as measles virus, cyt...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1054/mehy.2000.1247

    authors： Binstock T

    更新日期：2001-04-01 00:00:00

  • Pathophysiology of postoperative delirium: systemic inflammation as a response to surgical trauma causes diffuse microcirculatory impairment.

    abstract：:Postoperative delirium represents a serious complication after major surgery. Patients suffer from anxiety, hallucinations and delusions, and have higher postoperative morbidity and mortality. Generally, the role of acetylcholine deficiency in delirium pathophysiology is widely accepted. How this pathologic state evol...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2006.07.003

    authors： Hála M

    更新日期：2007-01-01 00:00:00

  • On the physiological function of lithium from a psychiatric view point.

    abstract：:Lithium is a naturally occurring alkali metal, which living organisms ingest from dietary sources and which is also present in trace amounts in the human body. In much higher concentrations, lithium is effective as a medication for mania and mood swings including manic depressive disorders. Many studies have shown tha...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1054/mehy.2001.1375

    authors： Demling JH,Eglau MC,Autenrieth T

    更新日期：2001-10-01 00:00:00

  • Folic acid supplementation as adjunctive treatment premature ejaculation.

    abstract：:Selective serotonin re-uptake inhibitors (SSRIs), has been increasingly used for the treatment of premature ejaculation over the past 5 years. It was reported that folic acid plays important roles in synthesis of 5-HT. Therefore, we hypothesize that folic acid supplementation may cures premature ejaculation by the sam...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2010.11.006

    authors： Yin TL,Yang J,Zhang B,Yan WJ,Xu WM,Li W,Yu L,Li SJ,Wu GX

    更新日期：2011-03-01 00:00:00

  • Treatment of trauma with lithium to forestall the development of posttraumatic stress disorder by pharmacological induction of a mild transient amnesia.

    abstract：:Posttraumatic stress disorder (PTSD) is a severe anxiety disorder that develops after exposure to trauma. Symptoms include persistent reexperiencing, persistent avoidance, persistent numbing, and persistent hyperarousal. Subsequent to trauma exposure, the onset of symptoms of an acute stress reaction can typically dev...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2013.02.017

    authors： Wallace J

    更新日期：2013-06-01 00:00:00

  • Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppr...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2016.12.006

    authors： Damar U,Gersner R,Johnstone JT,Schachter S,Rotenberg A

    更新日期：2017-02-01 00:00:00

  • ACTH regulates blood pressure in man.

    abstract：:In normal and hypertensive subjects, many stimuli which increase ACTH secretion also increase blood pressure and conversely, many drugs which decrease ACTH secretion also decrease blood pressure. We postulate that the hypothalamopituitary adrenal axis plays a role in blood pressure regulation in normal and hypertensiv...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(87)90014-4

    authors： Whitworth JA,McLachlan-Troup N,Scoggins BA

    更新日期：1987-07-01 00:00:00

  • Controllable metastasis: the trap for the esophageal cancer cells?

    abstract：:The prognosis of esophageal cancer (EC) remains poor, lymph node metastasis is one of the most important factors for determining the prognosis of patients with EC. Extensive lymph node dissection has long been considered as the favorable procedure to achieve an accurate pathologic staging and a better prognosis. Howev...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2010.01.017

    authors： Guo W,Ma Z,Zhao YP,Jiang YG

    更新日期：2010-06-01 00:00:00

  • Gene-gene coordination by the nuclear envelope.

    abstract：:The paper studies how certain topologic features of the nuclear envelope may reorganize entrained transcription via spatial rearrangements of genes carried by distinct chromatids. ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(95)90202-3

    authors： Matioli GT

    更新日期：1995-07-01 00:00:00

  • The estrogen connection: the etiological relationship between diabetes, cancer, rheumatoid arthritis and psychiatric disorders.

    abstract：:For some considerable time, there has been a growing awareness that defective essential fatty acid metabolism plays a causal role in the pathogenesis of both schizophrenia and non-insulin-dependent diabetes mellitus (NIDDM) but the influence of defective essential fatty acid metabolism in the pathogenesis of rheumatoi...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(95)90066-7

    authors： Holden RJ

    更新日期：1995-08-01 00:00:00

  • Lithium and viruses.

    abstract：:The activity of the lithium ion against DNA type viruses is explained by its competition with magnesium ions. Magnesium acts as the cofactor of the enzymes responsible for the replicative building of viral proteins and nucleosides. When lithium replaces magnesium, it appears to render the polymerase enzymes impotent. ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(87)90152-6

    authors： Bach RO

    更新日期：1987-06-01 00:00:00

  • Antibodies as oncogenes: a hypothesis.

    abstract：:We would like to put forward the hypothesis that cancer patients may produce autoantibodies that promote uncontrolled cell growth and thereby function as oncogenes. Dying cells release proteins that stimulate the production of autoantibodies, an event also known to occur during the earliest stages of tumor growth. If ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2006.03.006

    authors： Admon A,Shoshan SH

    更新日期：2006-01-01 00:00:00

  • Depressed exocytosis and endocytosis of type II alveolar epithelial cells are responsible for the surfactant deficiency in the lung of newborn with congenital diaphragmatic hernia.

    abstract：:Exocytosis and endocytosis are the way of macromolecules transmembrane transport. Pulmonary surfactant (PS), one of such macromolecules, is secreted via exocytosis of lamellar bodies and recycled via endocytosis by type II alveolar epithelial cells (AEC II). It maintains low alveolar surface tension and is therefore e...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2008.09.012

    authors： Xu C,Liu W,Wang Y,Chen Z,Ji Y

    更新日期：2009-02-01 00:00:00

  • What decides the nature of extraocular muscle injury? The probable mechanism of flap tear and rupture.

    abstract：:The assessment of nature and the extent of extraocular muscle injuries during initial visit in ocular emergencies is of paramount importance to avoid/minimize the subsequent need for strabismus surgery. Based on our experience in managing acute globe and orbital injuries and cases of strabismus, we propose the probabl...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2019.01.011

    authors： Pujari A,Saxena R,Sharma P,Phuljhele S

    更新日期：2019-02-01 00:00:00

  • The progression of the tubulointerstitial fibrosis driven by stress-induced "proliferation-death" vicious circle.

    abstract：:Several hypotheses have been developed to interpret the progression of tubulointerstitial fibrosis (TF), including senescence, epithelial-mesenchymal transition, inflammation, chronic hypoxia, and reactive oxygen species. All of these hypotheses are based on persistent cell injury and localized cell death. Proliferati...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2014.01.014

    authors： Chen BC,Bai YH,Tang LL,Wang BQ,Liu B,Cai Y,Peng X,Yang YR,Zheng SL

    更新日期：2014-06-01 00:00:00

  • Pharmacotherapy and psychotherapy in the treatment of psychiatric disturbances.

    abstract：:The type of treatment that most psychiatric disturbances receive at present is a mixture of pharmacotherapy and psychotherapy, following the principle that mental functions are the result of the activities of brain machinery subsequent to the interaction between individuals and their external environment. We now know ...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1054/mehy.1997.0774

    authors： Galzigna L

    更新日期：1999-01-01 00:00:00

  • Adaptive and maladaptive cortisol responses to pediatric obesity.

    abstract：:The recent unprecedented increase of childhood obesity has led to an alarming rise in type 2 diabetes mellitus (T2D) among these children. The process underlying the progression from simple obesity to T2D is not well understood. Cortisol is a candidate factor in the pathogenesis of T2D, as it can exacerbate insulin re...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/j.mehy.2008.04.020

    authors： Soros A,Zadik Z,Chalew S

    更新日期：2008-09-01 00:00:00

  • Coronary vasospasm: a neuro-behavioral event?

    abstract：:Evidence exists for the presence of a neuro-anatomy that can produce cardiac vasospasm. Recent experimental and clinical data suggest that this neuro-anatomic mechanism can be activated by behavioral events in the psycho-social surround of the patient with coronary artery disease. I hypothesize that this mechanism can...

    journal_title：Medical hypotheses

    pub_type： 杂志文章

    doi：10.1016/0306-9877(87)90214-3

    authors： Natelson BH

    更新日期：1987-12-01 00:00:00

  • Humoral immunity in measles infection: a critical factor?

    abstract：:Cell-mediated immunity is generally regarded as the essential factor in recovery from measles infection. In other viral infections humoral immunity has been considered a critical factor when antibody titres were correlated with outcome or when serum therapy proved protective. A review of available studies of severe-to...

    journal_title：Medical hypotheses

    pub_type： 杂志文章,评审

    doi：10.1016/0306-9877(87)90020-x

    authors： Aaby P,Bukh J,Hoff G,Lisse IM,Smits AJ

    更新日期：1987-07-01 00:00:00