Abstract：
:Selective serotonin re-uptake inhibitors (SSRIs), has been increasingly used for the treatment of premature ejaculation over the past 5 years. It was reported that folic acid plays important roles in synthesis of 5-HT. Therefore, we hypothesize that folic acid supplementation may cures premature ejaculation by the same mechanism of interacting with monoamine neurotransmitters in brain, to be the replacement of RRSIs. Folic acid supplementation cures premature ejaculation more safely. These new views will help to understand the diagnosis and treatment methods for premature ejaculation.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Yin TL,Yang J,Zhang B,Yan WJ,Xu WM,Li W,Yu L,Li SJ,Wu GXdoi
10.1016/j.mehy.2010.11.006subject
Has Abstractpub_date
2011-03-01 00:00:00pages
414-6issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(10)00469-Xjournal_volume
76pub_type
杂志文章abstract：:Oesophageal carcinoma is a devastating disease with a poor prognosis. This hypothesis shows how prostaglandin E2 exerts carcinogenic effects in the oesophagus. The contribution of prostaglandin E2 is related to other factors that predispose to oesophageal carcinoma. The implication of the hypothesis is that nonsteroid...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90285-1
更新日期：1997-02-01 00:00:00
abstract：:Accurate detection and prevention of overuse musculoskeletal injuries is limited by the nature of somatic tissue injury. In the pathogenesis of overuse injuries, it is well recognized that an abnormal inflammatory response occurs within somatic tissue before pain is perceived which can disrupt the normal remodeling pr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.12.003
更新日期：2016-02-01 00:00:00
abstract：:This hypothesis clearly proposes the true and previously undiscovered cause of male homosexuality or bisexuality and in most cases the predictability in infancy of the development of this sexuality in adulthood. It is based on compelling new evidence which has accumulated over many years. The fetal and neonatal period...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.06.006
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:Results from a recent study showed that the risk of cardiovascular and all-cause mortality was higher in patients who received febuxostat, a potent urate-lowering agent, than that in patients who received allopurinol. Therefore, we hypothesized that an abrupt change in serum urate levels caused by urate-lowe...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109740
更新日期：2020-08-01 00:00:00
abstract：:The exact contribution of the sirtuin family of NAD+-dependent histone deacetylases to longevity in metazoans is, at present, not completely understood but nonetheless regarded as significant. Despite the rapidly accreting evidence solidifying the role of NAD+-dependent histone deacetylase activity in longevity-promot...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.08.032
更新日期：2006-01-01 00:00:00
abstract：:The science of osteoimmunology, a relatively new field of research, reveals the important interactions between the immune system and skeletal system. Interactions occur between prostaglandin metabolism, inflammatory proteins and bone metabolism. Systemic as well as local sources of inflammation appear to be actively i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.03.042
更新日期：2013-08-01 00:00:00
abstract：:Class II malocclusion is one of the most common orthodontic problems. The main aetiology of Class II malocclusion is mandibular retrognathia. A variety of functional appliances have been used to stimulate mandibular growth in adolescence, however, the effects remain unsatisfactory. Therefore, new approaches are in nee...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.08.029
更新日期：2009-03-01 00:00:00
abstract：:This paper discusses a mechanism for converting heterochromatin into the more relaxed state of euchromatin. Actuation of such state conversion stems from disassembly of internal vesicles that are incapable of surviving when trapped within the inner chamber of mammalian nuclei. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00233-5
更新日期：2002-11-01 00:00:00
abstract：:The hepatitis B infection leads to various profound pathological processes in liver metabolism. Some biochemical alterations detectable by blood analysis are currently used for a preliminary evaluation of the infection. Based on existing data we present here evidence that non-protein amino acid L-homoserine is a patho...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1527
更新日期：2002-04-01 00:00:00
abstract：:The favourable effects of eicosapentaenoic acid (EPA)- and doco-sahexaenoic acid (DHA)-rich diets (marine fish, fish oil) on several risk factors for cardiovascular disease are well established. The present survey describes possible new indications for diets supplemented with long-chain n-3 fatty acids. During a stand...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90169-y
更新日期：1991-09-01 00:00:00
abstract：:Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control effor...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.03.025
更新日期：2011-07-01 00:00:00
abstract：:Inadequately responsive glycaemic control is an important factor in the causation of diabetic end-organ damage. Artificial or hybrid bioartificial pancreases can provide responsive glycaemic control that can reduce the enormous personal suffering and socio-economic costs of diabetes. However, they share the shortcomin...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.08.047
更新日期：2007-01-01 00:00:00
abstract：:Data on lymphocyte biology indicate that the humoral system of B-cells is specifically active with precise analogies at all mucosal levels. Might there be a corresponding function for T-lymphocytes at the cutaneous structure level? Certain physiological findings appear to suggest that the two main lymphocyte populatio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90060-8
更新日期：1981-09-01 00:00:00
abstract：:The hypothesis is proposed that: 1. Aflatoxin B1 and polycyclic hydrocarbon carcinogens cause the deletion of genes necessary for the production of a substance required for differentiation of the cell and activated by a steroid hormone possibly a corticosteroid. 2. Such genes could include genes for production of: glu...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(79)90046-x
更新日期：1979-09-01 00:00:00
abstract：:Sickle cell anaemia confirms that minor mutations in protein sequence can have catastrophic effects. However, RNA transcription depends on polymerases that have low fidelity and introduce errors at a rate of 10(-5) substitutions/base synthesised. For many large proteins translation of these errors could result in sign...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.02.024
更新日期：2004-01-01 00:00:00
abstract：:Therapies for preventing reperfusion injury (RI) have been widely studied. However, the attempts to transfer cardioprotective therapies for reducing RI from experiments into clinical practice have been so far unsuccessful. Pathophysiological mechanisms of RI are complicated and compose of many pathways e.g. hypercontr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109558
更新日期：2020-04-01 00:00:00
abstract：:Dyslipidemia is a common pathology throughout the industrialized world, and HMG-CoA reductase inhibitors (statins) are often administered to treat elevated lipid levels. Substantial concern has been raised regarding the aggressive clinical lowering of cholesterol, particularly in light of a growing body of research li...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.10.018
更新日期：2016-12-01 00:00:00
abstract：:Chimeras are the result of fusion of two zygotes to form a single embryo, producing an individual with genetically different kinds of tissue. If the fused zygotes are of different sex, the individual develops both ovarian and testicular tissues. The majority of these people are best reared as females and many pregnanc...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.04.021
更新日期：2010-11-01 00:00:00
abstract：:As known, gamma-interferon-induced cell death in HeLa cells can be mediated via the recently identified protein kinase, death associated protein (DAP) kinase which is localized to the microfilament system of the cytoskeleton. However, the downstream or upstream effectors of DAP kinase remain uncertain. In the present ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0967
更新日期：2000-05-01 00:00:00
abstract：:Studies have reported an increasing incidence of thyroid cancer worldwide. The reasons are likely related to improved imaging modalities, altered histopathologic criteria for diagnosis of thyroid cancer, and nuclear exposure. However, the classical assumption derived from epidemiological studies is that it should be q...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.08.021
更新日期：2010-01-01 00:00:00
abstract：:Retinopathy of prematurity (ROP) is a disease of the immature retina and is the leading global cause of blindness in children. Two postnatal phases of the disease are distinguished, the first phase is thought to be caused by hyperoxia. One of the most relevant ROP risk factor in routine clinical practice is blood tran...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109541
更新日期：2020-04-01 00:00:00
abstract：:The prevalence of atopic diseases (atopic dermatitis, bronchial asthma, allergic rhinitis) has considerably increased for the last 40 years. This tendency has coincided with the beginning of the epoch of the use of the topical corticosteroids, which have a potent immunomodulation action. This fact itself as well as a ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.059
更新日期：2005-01-01 00:00:00
abstract：:Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the prof...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.09.010
更新日期：2017-11-01 00:00:00
abstract：:Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe), manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium (Ca) - have been observed in the foodchains that traditionally support the Chamorro populations affected by high incidence clusters of Alzheimer (AD), Parkinson-like ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.04.029
更新日期：2004-01-01 00:00:00
abstract：:In contrast to Geschwind, Behan and Galaburda (GBG) theory, there is strong evidence that inheritance through maternal line is responsible for the coexistence of asthma and left-handedness early in childhood. A new model that incorporates GBG's theory and maternal inheritance is proposed. This hypothesis suggests that...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00325-6
更新日期：2004-01-01 00:00:00
abstract：:The problem how tumor cells get the metastatic ability is still a hot debate. Based on the premise that the default state of normal cells is quiescent rather than mobile, the classic progression and early metastasis model suggested that tumor metastasis should be an acquired trait contributed by the late or early gene...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.11.023
更新日期：2010-05-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the most common primary tumor of liver and its incidence continues to increase worldwide. HCC is a disease with multifactorial causes and genetic variability has been discussed as a risk factor for its development. Liver is a hormone-sensitive organ and therefore is influenced by gona...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.11.030
更新日期：2016-01-01 00:00:00
abstract：:Noonan syndrome (NS OMIM 163950) is a relatively common autosomal dominant developmental disorder characterized by short stature, specific facial features, and congenital cardiac anomalies. Approximately 50-66% of cases have defined mutations in the K-ras/Raf/MEK/ERK pathway that lead to constitutive signaling, but a ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.01.040
更新日期：2009-07-01 00:00:00
abstract：:Malignant hyperthermia (MH) is a rare myopathy inducing severe accident when carriers are exposed to triggering agents. MH susceptibility (MHS) is assessed by pharmacological tests performed on muscle strips. Exertional heat stroke (EHS) is a severe accident occurring during long and strenuous exercise. It has been ob...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90116-7
更新日期：1995-09-01 00:00:00
abstract：:Endometriosis is a common gynecological disorder that affects approximately 6-10% of the female population impairing the quality of life of patients. Several pathophysiologic pathways have been proposed as potential regulators of its severity; however, to date, the processes that trigger the onset and that influence t...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2019.109414
更新日期：2019-12-01 00:00:00
