Abstract：
:We would like to put forward the hypothesis that cancer patients may produce autoantibodies that promote uncontrolled cell growth and thereby function as oncogenes. Dying cells release proteins that stimulate the production of autoantibodies, an event also known to occur during the earliest stages of tumor growth. If some of these autoantibodies are directed against cell surface hormone receptors, they could oligomerize the receptors and inadvertently transmit growth signals. The abnormal signals could result in uncontrolled cell proliferation and, eventually, oncogenesis. Thus, some specific autoantibodies from among the large repertoires of autoantibodies present in the sera of cancer patients are, in reality, oncogenes. If such oncogenic autoantibodies are indeed present and can be identified, inhibition of their molecular action may be an effective therapeutic modality.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Admon A,Shoshan SHdoi
10.1016/j.mehy.2006.03.006subject
Has Abstractpub_date
2006-01-01 00:00:00pages
471-3issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(06)00186-1journal_volume
67pub_type
杂志文章abstract：:Treatment for stuttering attempts to reduce or eliminate the observable core markers of the disorder, specifically repetitions and prolongation. In this hypothesis, it is proposed that stuttering may be inhibited by two distinct yet related procedures: active inhibition and passive inhibition. Active inhibition is bro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1452
更新日期：2002-01-01 00:00:00
abstract：:This hypothesis agrees with Le Vay's suggestion that the two phenomena of childhood behavior and adult sexuality are induced by separate events rather than being two events in a single chain. However, it differs from Le Vay in that it includes the postnatal period, as being of crucial importance in the development of ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90006-7
更新日期：1996-02-01 00:00:00
abstract：:Parathyroid hormone (PTH) acts as a controller of bone remodeling and has influence on periodontal tissues. In addition to the well-established catabolic effects (activation of bone resorption) of PTH, it is recognized that the PTH intermittent administration has anabolic effects (promotion of bone formation). However...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.12.025
更新日期：2016-03-01 00:00:00
abstract：:Exacerbation of certain medical conditions during specific phases of the menstrual cycle has long been recognized. Mechanisms of the cyclic variations are poorly understood, but are often attributed to fluctuations in reproductive hormones. We hypothesize that normal variations in autonomic balance during the menstrua...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.02.036
更新日期：2004-01-01 00:00:00
abstract：:Seizure (ictal) behavior in humans has been observed and recorded since ancient times. A satisfactory solution to this vexing problem continues to elude medical science. Antiepileptic drug (AED) therapy fails to control seizures in 20% of patients with primary generalized epilepsy and 35% of patients with partial epil...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/s0306-9877(02)00348-1
更新日期：2003-01-01 00:00:00
abstract：:The Sudden Infant Death Syndrome (SIDS) is responsible for the death of 10,000 infants annually in the U.S.A. The cause of these deaths is not known; all SIDS infants studied died during sleep in a silent fashion and there are no specific lesions observable post mortem. It may be of significance, however, that nearly ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(87)90195-2
更新日期：1987-03-01 00:00:00
abstract：:The interstitial space (ISS) can be thought of as an organ of translocation. Defined in this way the concentration of any substance in the ISS is equal to the ratio of an input to a clearance function. When substances accumulate, there is a disturbance of one or both functions. The three phase anatomy of the ISS give ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(80)90040-7
更新日期：1980-09-01 00:00:00
abstract：:A hypothetical pathogenesis for a typical case of amyotrophic lateral sclerosis (ALS) follows from opinions of Rowland and results of neuroscientists at Baylor. ALS might typically result from an autoimmune disorder that causes IgG to enhance release of acetylcholine (ACh) from axon terminals. Motor neuron overactivit...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90160-0
更新日期：1994-06-01 00:00:00
abstract：:Increased longevity is compromised for the quality of life due to prevalence of metabolic derangements and systemic degenerative disorders, as a result of lifestyle changes in modern days. In a craze to improve upon quality of life, use of pharmacological formulations aimed towards symptomatic treatment regimen is man...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.09.069
更新日期：2007-01-01 00:00:00
abstract：:Acute renal failure (ARF) is a rapid loss of kidney function. The reasons and mechanism by which this occurs has not been clarified so far thus creating obstacles to management of this disease. Presently, the experimental research using the accepted renal ischemia reperfusion injury (I/R injury) model represented for ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.12.041
更新日期：2013-04-01 00:00:00
abstract：:Mood expressions encompassing positive scales like "activity, elation, contemplation, calmness" and negative scales like "anger, excitement, depression, fatigue" were applied for introducing a new tool to assess the effects of acupuncture on brain structures. Traditional acupuncture points defined in the literature fo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.05.013
更新日期：2015-09-01 00:00:00
abstract：:In a previous paper we predicted that health effects of dietary fats in humans would require half a century or more to be understood, instead of the decade or so predicted during 1956 by an Editorial in The Lancet. It would seem that our prediction may have been optimistic since it has now been reported that trans uns...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90194-h
更新日期：1992-04-01 00:00:00
abstract：:Crossed cerebellar diaschisis (CCD) refers to transneuronal degeneration of the corticopontocerebellar pathway, resulting in atrophy of cerebellum contralateral to supratentorial pathology. CCD is traditionally diagnosed on nuclear medicine studies. Our aim is to apply a biexponential diffusion model, composed of intr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.08.025
更新日期：2018-11-01 00:00:00
abstract：:Diabetic individuals frequently suffer from skin pathologies, especially in their feet. Co-existing peripheral vascular disease and neuropathy exacerbate the capacity of these individuals to cope with infections, minor cuts and wounds, often leading to hard to treat and chronic ulcers. Copper has potent anti-fungal an...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.02.050
更新日期：2009-12-01 00:00:00
abstract：:Relapse to cocaine, heroin, and alcohol is a common occurrence in ex-abusers of these substances. Although there are many potential causes for relapse, we postulate that one cause in some people may be re-exposure in an anesthesia setting to a drug similar to the formerly abused drug. We hypothesize, for example, that...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0797
更新日期：1999-12-01 00:00:00
abstract：:Exercise is thought to have considerable potential as a preventive for osteoporosis. We critically examined 27 studies that address the prophylactic role of exercise in osteoporosis. The results from both cross-sectional and longitudinal studies showed that differences in bone mass were more pronounced in the axial sk...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/0306-9877(89)90118-7
更新日期：1989-09-01 00:00:00
abstract：:Anemia of chronic disease (ACD) is a condition of decreased red cell mass secondary to some other chronic inflammatory condition. In ACD total body iron stores are normal, though serum iron is typically low secondary to iron sequestration by macrophages, and often iron supplementation is not an effective treatment for...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.01.036
更新日期：2005-01-01 00:00:00
abstract：:The hypothesis is proposed that: 1. Aflatoxin B1 and polycyclic hydrocarbon carcinogens bind to the regions of DNA to which steroid hormones bind and cause the deletion of genes in these regions. 2. The deletion of these genes may be responsible for a reduced number of ribosomes bound to the endoplasmic reticulum. 3. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(77)90063-9
更新日期：1977-07-01 00:00:00
abstract：:Oxidative stress-mediated neurodegeneration is responsible for 12% mortality around the globe. Alzheimer's Disease (AD) and Parkinson's Disease (PD) are the most prevalent neurodegenerative diseases, associated with modulation of acetylcholine levels and amyloid beta accumulation & dopamine level and alpha-synuclein o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109872
更新日期：2020-10-01 00:00:00
abstract：:The objective of this work is to propose a biomechanical model of sacro-iliac joint dysfunction as a cause of low back pain. Sacro-iliac joint is known to be a source of low back pain. We also know that it is a very stable joint with little mobility. Surrounding lower limb and back muscles contribute a major part of t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.02.035
更新日期：2005-01-01 00:00:00
abstract：:The modern living standard has imposed upon society a situation of chronic sleep deprivation. This chronic loss of sleep affects women more than it does men. As a result, the postponement of pregnancy has become a common choice due to the priority given to social and domestic activities. For women, pregnancy represent...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.07.036
更新日期：2010-12-01 00:00:00
abstract：:Preeclampsia (PE) and gestational diabetes mellitus (GDM) are two of the most common medical complications of pregnancy, with risks for both mother and child. Like many other antepartum complications, PE and GDM occur only in pregnancy. However, it is not clear if pregnancy itself is the cause of these complications o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.04.019
更新日期：2012-07-01 00:00:00
abstract：:Stroke is a major cause of neurological disability across all countries in the world. Functional recovery after stroke is limited because of neuronal death and degeneration. Although early reperfusion therapy may improve outcome, thrombolysis does not reverse ischaemic neuronal death and carries the risk of cerebral h...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.01.091
更新日期：2007-01-01 00:00:00
abstract：:A review of the literature shows that x-ray induced lung adenomas in mice, breast adenomas in rats and thyroid adenomas in rats show the same approximate dependence for number of tumors vs dose. It is hypothesized that these benign tumors are due to cell proliferation. The controls of the G1 stage of the cell cycle ha...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(83)90049-x
更新日期：1983-01-01 00:00:00
abstract：:Pelvis is a functional shell-like unit consisting of the pelvic floor and perineum. The patients, who underwent a radical operation of the pelvis due to an oncological disease, often develop pelvic disorders. These disorders do not depend on the type of surgery or any presence of postoperative treatment (radio- and ch...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.10.019
更新日期：2009-03-01 00:00:00
abstract：:The paper discusses a mechanism for reciprocal translocation of midsegments between two chromatids so that one of the segments is restacked in inverted configuration. Regarding malignant cells, such process could derive from anachronistic assembly of the nuclear envelope. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90277-8
更新日期：1998-06-01 00:00:00
abstract：:Immunotherapy has attracted attention as a novel treatment modality for malignant melanoma. Although the use of immunotherapy in metastatic melanoma has shown promising results, there remains a lack of predictive biomarkers indicating treatment benefit from immunotherapy. There is growing evidence suggesting that micr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.05.023
更新日期：2016-08-01 00:00:00
abstract：:Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(89)90194-1
更新日期：1989-07-01 00:00:00
abstract：:Dementia and other causes of functional disability can create considerable burdens for families and society as a whole, but it may be possible to partially alleviate this strain through technical innovations that replace some functions of human caregivers. This article proposes the hypothesis that cell phones, interne...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.11.045
更新日期：2006-01-01 00:00:00
abstract：:Under the headline "drug addiction" the medical world has exclusively been interested in psychoactive drugs. For diagnosis of substance dependence (addiction), DSM-IV-TR has determined seven criteria, and fulfilling at least tree of them signifies addiction. When studied salt intake according to these criteria it is s...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.04.041
更新日期：2006-01-01 00:00:00
