Abstract：
:The interstitial space (ISS) can be thought of as an organ of translocation. Defined in this way the concentration of any substance in the ISS is equal to the ratio of an input to a clearance function. When substances accumulate, there is a disturbance of one or both functions. The three phase anatomy of the ISS give it unique properties including a high resistance to bulk flow, normal or even augmented diffusion of small ions, marked restriction to macromolecular transport, and some specificity for binding certain substances. Depositional disease in the interstitium can be approached in terms of minimizing the input function or maximizing the clearance function of the deposited substance. In the near future the clinician will have access to importance physical parameters of the ISS.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Katz MAdoi
10.1016/0306-9877(80)90040-7subject
Has Abstractpub_date
1980-09-01 00:00:00pages
885-98issue
9eissn
0306-9877issn
1532-2777pii
0306-9877(80)90040-7journal_volume
6pub_type
杂志文章abstract：:Organisms release their antigens into the environment. Some antigens are volatile and may pass into the blood of other organisms during respiration. Fetal antigens enter the mother's bloodstream through the placenta. Foreign antigens in the blood can cause various chemical changes and may initiate an immune reaction. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90211-2
更新日期：1995-07-01 00:00:00
abstract：:Studies have reported an increasing incidence of thyroid cancer worldwide. The reasons are likely related to improved imaging modalities, altered histopathologic criteria for diagnosis of thyroid cancer, and nuclear exposure. However, the classical assumption derived from epidemiological studies is that it should be q...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.08.021
更新日期：2010-01-01 00:00:00
abstract：:What causes cancer? To date, this question is left with no answer. The scientific community keeps defining cancer as a proliferation of cells in an uncontrolled and uncontrollable manner. The hypothesis developed here through an understanding of the cancer cell's behaviour led to its re-definition, providing answers t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1532
更新日期：2002-06-01 00:00:00
abstract：:The Sudden Infant Death Syndrome (SIDS) is responsible for the death of 10,000 infants annually in the U.S.A. The cause of these deaths is not known; all SIDS infants studied died during sleep in a silent fashion and there are no specific lesions observable post mortem. It may be of significance, however, that nearly ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(87)90195-2
更新日期：1987-03-01 00:00:00
abstract：:The molecular similarity between certain human antigenic determinants with those of HIV has been already described. In this matter, we have previously demonstrated, by a chromatographic method, the cross reactivity of human serum albumin with HIV gp 120. The hypothesis that this similarity could be one of the reasons ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1520
更新日期：2002-05-01 00:00:00
abstract：:Chronic viral liver disease may evolve to cirrhosis. The medical treatment to slow down this passage is based on anti-viral and anti-fibrotic properties of interferon. Recently, we evidenced significant increase of portal vein flow velocity and volume after a prostacyclin analog (iloprost) infusion in subjects without...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.05.017
更新日期：2005-01-01 00:00:00
abstract：:In UK educational circles it has long been regarded as a platitude that a good scientific education at school and undergraduate level should aim to teach critical thinking and encourage students to challenge mainstream science, debate scientific issues and express their personal opinions. However, I believe that this ...
journal_title：Medical hypotheses
pub_type： 社论
doi：10.1016/j.mehy.2009.07.050
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:There is widespread loss of acetylcholine and other neurotransmitters in Alzheimer's disease and vascular dementia. It has generally been assumed that death of neurons causes neurotransmitter loss, but alternatively neurotransmitter depletion itself may at least contribute to neurodegeneration. PRESENTATION...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.02.043
更新日期：2006-01-01 00:00:00
abstract：:Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large numbe...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2019.109448
更新日期：2020-02-01 00:00:00
abstract：:Placebo controlled trials in disease states as currently constituted are designed to show a drug "works" when in fact it may not. Efficacy of this type may be constructed in trials that demonstrate some marginal superiority of a drug over placebo in disease states that do not take into account any potentialities of th...
journal_title：Medical hypotheses
pub_type： 社论,历史文章,评审
doi：10.1016/j.mehy.2010.01.038
更新日期：2010-05-01 00:00:00
abstract：:Juvenile nasopharyngeal angiofibroma (JNA) is the most common benign tumor of the nasopharynx. For reasons unknown, this tumor is found almost always in male population. However, site of origin of JNA is still an enigma. Previously, JNA was considered to arise from the superior aspect of sphenopalatine foramen. Over l...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110300
更新日期：2020-11-01 00:00:00
abstract：:Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109938
更新日期：2020-11-01 00:00:00
abstract：:About 19-26% of patients with chronic lymphocytic leukemia (CLL) have intractable disease resistant to chemotherapy, have a relatively short median survival time and are responsive to splenectomy. Lymphocytes from patients with intractable CLL are resistant in vitro to X-irradiation and to colchicine. Responsive CLL i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(90)90001-u
更新日期：1990-02-01 00:00:00
abstract：:A model of human language requires a theory of meaningful marks. Humans are the only species who use marks to think. A theory of marks identifies children's scribbles as significant behavior, while hypothesizing the importance of rotational systems to hominid brain evolution. By recognizing the importance of children'...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.09.002
更新日期：2005-01-01 00:00:00
abstract：:The results described in this paper partially agree with the hypothesis that mesenteric lymph nodes (MLN) of depleted growing rats recover their antigen specific determinants after the oral administration of 20% casein for 5-9 days following the time course of antigen dependent changes observed in virgin lymph nodes. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(87)90058-2
更新日期：1987-08-01 00:00:00
abstract：:Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10-20%. Approximately 90% of survivors will have moderate to severe neurological injury ranging from moderate cognitive impairment to brain ...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2017.06.016
更新日期：2017-08-01 00:00:00
abstract：:Increased chemotactic activity of peripheral polymorphonuclear (PMN) cells has been described in disease states of different etiology and may represent a common pathway in the generation of an inflammatory reaction. The suppressive effect of colchicine on PMN chemotaxis may explain its effect in apparently unrelated d...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90017-7
更新日期：1981-01-01 00:00:00
abstract：:We develop here the hypothesis that polycystic kidneys (PCK) may maintain, to a certain extent, the ability to perform endocrine functions. We know that patients with adult polycystic kidney disease (APCKD) produce more erythropoietin and maintain a higher hematocrit than patients with other primary diseases of the ki...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(89)90127-8
更新日期：1989-09-01 00:00:00
abstract：:The prognosis of esophageal cancer (EC) remains poor, lymph node metastasis is one of the most important factors for determining the prognosis of patients with EC. Extensive lymph node dissection has long been considered as the favorable procedure to achieve an accurate pathologic staging and a better prognosis. Howev...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.01.017
更新日期：2010-06-01 00:00:00
abstract：:There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compare...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.01.017
更新日期：2013-05-01 00:00:00
abstract：:No survival profit has been achieved for patients with disseminated prostate cancer since hormonal therapy was introduced. It is proposed that dissemination of rare prostatic cancer stem cells may lead to metastatic disease and that resistance of these cells to androgen ablation makes them responsible for failure of c...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.06.021
更新日期：2008-11-01 00:00:00
abstract：:Accurate detection and prevention of overuse musculoskeletal injuries is limited by the nature of somatic tissue injury. In the pathogenesis of overuse injuries, it is well recognized that an abnormal inflammatory response occurs within somatic tissue before pain is perceived which can disrupt the normal remodeling pr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.12.003
更新日期：2016-02-01 00:00:00
abstract：:Dyslipidemia is a common pathology throughout the industrialized world, and HMG-CoA reductase inhibitors (statins) are often administered to treat elevated lipid levels. Substantial concern has been raised regarding the aggressive clinical lowering of cholesterol, particularly in light of a growing body of research li...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.10.018
更新日期：2016-12-01 00:00:00
abstract：:Numerous medical conditions present with acute and severe autonomic and muscular overactivity. These syndromes include Neuroleptic Malignant Syndrome, Serotonin Syndrome, Dysautonomia (or paroxysmal sympathetic storms) following acquired brain injury, Autonomic Dysreflexia, Parkinsonian-Hyperpyrexia Syndrome, Malignan...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.04.037
更新日期：2008-01-01 00:00:00
abstract：:One of the most affected cognitive impairments in children who experienced heavy burdens of diarrhea is semantic fluency, the same impairment that is most affected in Alzheimer's dementia. These findings are leading us into provocative genetic studies that may elucidate the evolution of such genetic polymorphisms as t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.05.013
更新日期：2009-11-01 00:00:00
abstract：:There are different theories and hypotheses related to the aetiology of depression. The interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood changes and depression. In major depression, activation of the inflammatory response system (IRS) and, increased concentrations of proi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00207-x
更新日期：2003-11-01 00:00:00
abstract：:Oxidative stress-mediated neurodegeneration is responsible for 12% mortality around the globe. Alzheimer's Disease (AD) and Parkinson's Disease (PD) are the most prevalent neurodegenerative diseases, associated with modulation of acetylcholine levels and amyloid beta accumulation & dopamine level and alpha-synuclein o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109872
更新日期：2020-10-01 00:00:00
abstract：:Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric b...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.08.012
更新日期：2017-09-01 00:00:00
abstract：:There is a striking resemblance, in amino-acid composition and properties, between one class of structural glycoproteins from connective tissue and the apo low density lipoproteins (LDL) of blood plasma. It is suggested that there is a structurally specific analogy between the early atherogenic accumulation of LDL (an...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(76)90039-6
更新日期：1976-09-01 00:00:00
abstract：:COVID-19 due to the SARS-CoV-2 infection is a multi-systemic immune syndrome affecting mainly the lungs, oropharyngeal region, and other vascular endothelial beds. There are tremendous ongoing efforts for the aim of developing drugs against the COVID-19 syndrome-associated inflammation. However, currently no specific ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110150
更新日期：2020-10-01 00:00:00
