Iloprost: an adjunctive approach to chronic viral hepatitis treatment.

abstract：:It has been speculated that the rise of the adaptive immune system in jawed vertebrates some 400 million years ago gave them a superior protection to detect and defend against pathogens that became more elusive and/or virulent to the host that had only innate immune system. First, this line of thought implies that ada...

journal_title：Medical hypotheses

authors： Usharauli D

更新日期：2010-08-01 00:00:00

abstract：:The available epidemiological data for amyotrophic lateral sclerosis (ALS) support an infectious etiology and lead us to propose a new hypothesis. We examined older epidemiological data concerning categories of the population with increased incidence (aged people, people living in rural areas, farmers, breeders), more...

journal_title：Medical hypotheses

authors： Stipa G,Taiuti R,de Scisciolo G,Arnetoli G,Tredici MR,Biondi N,Barsanti L,Lolli F

更新日期：2006-01-01 00:00:00

abstract：:Cancer stem cells are a small population of tumor cells that have many malignant features such as chemotherapy resistance, radiotherapy resistance, tumorigenicity and are responsible for tumor progression, disease recurrence and metastasis. Therefore, insight into the regulation of the biology of cancer stem cells is ...

journal_title：Medical hypotheses

authors： Lin S,Fu S

更新日期：2013-04-01 00:00:00

abstract：:A method for fast nucleotide sequencing is described. It is based in the selection of well-known small oligomers able to be hybridized with the unknown target. The selected oligomers are afterwards ordered following a simple statistical approach. The use of capillary electrophoresis for the analysis is emphasized. ...

journal_title：Medical hypotheses

authors： Figureau A,Soto MA,Tohá J

更新日期：2000-07-01 00:00:00

abstract：:Lysosomes, lysosomal enzymes and oxidant processes are known to be involved in cancer processes. The prostasomes contain proteins and enzymes that would constitute pathways for the hydrolysis of proteins and peptides. However, integrated biochemical and cell biology studies are necessary to understand how lysosomal en...

journal_title：Medical hypotheses

authors： Tappel A

更新日期：2005-01-01 00:00:00

abstract：:It is proposed that gastrin promotes the uptake of divalent and trivalent metal ions from the gastrointestinal lumen by catalyzing the binding of metal ions to luminal albumin and transferrin respectively. The following observations are consistent with this hypothesis: 1. Gastrin binds both divalent and trivalent meta...

journal_title：Medical hypotheses

authors： Baldwin GS

更新日期：1992-05-01 00:00:00

abstract：:The goal in the treatment of osteonecrosis of the femoral head is to preserve, not replace, the femoral head. Although many methods have been proposed, none has proved completely satisfactory. Cellular mediators as a supplement to bone grafting and decompression is an attractive approach to this problem because it com...

journal_title：Medical hypotheses

authors： Yuan B,Liu Z

更新日期：2007-01-01 00:00:00

abstract：:Diabetes is a global public health challenge that imposes heavy burdens on communities and individuals. Metformin, the first-line medication for diabetes, has the superiority of reducing risk of macrovascular diseases, all-cause mortality and even possibly cancers. Recent observational studies, however, have demonstra...

journal_title：Medical hypotheses

authors： Xu L,Huang Z,He X,Wan X,Fang D,Li Y

更新日期：2013-08-01 00:00:00

abstract：:It is a known fact that individuals who engaged in delinquent behavior in childhood are more probable to carry on similar behavior in adulthood. If the factors that lead children to involve in delinquency are defined, the risk of dragging children into crime can be detected before they are involved in crime and delinq...

journal_title：Medical hypotheses

authors： Ucuz I,Ciçek AU,Ari A,Ozcan OO,Aybüke Sari S

更新日期：2020-10-01 00:00:00

abstract：:Encouraging results have been obtained with stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). However, local control rates decrease in larger volume disease. Several studies have found a correlation between T stage or tumor volume and local progression-free survival. In man...

journal_title：Medical hypotheses

authors： Nieder C,Andratschke N

更新日期：2012-04-01 00:00:00

abstract：:Reconciling the early promising results of radiation therapy in the treatment of epilepsy with the recent theory concerning the role of nonsynaptic mechanisms in focal epileptogenesis, it is suggested that the potential of irradiation as an alternative to temporal lobe resection in intractable epilepsy should be re-ev...

journal_title：Medical hypotheses

authors： Elomaa E

更新日期：1980-05-01 00:00:00

abstract：:The author presents evidence from published papers of research done by numerous investigators that Multiple Sclerosis (MS) is an autoimmune disease, that the target tissue is the myelin sheath which covers the nerve fibers in the brain and spinal cord, that Myelin Basic Protein (MBP) is the antigen or one of the antig...

journal_title：Medical hypotheses

authors： Eidinoff H

更新日期：1988-06-01 00:00:00

abstract：:Intractable epilepsy has always posed a challenge to management; conventional, surgical and alternative techniques available so far (e.g., vagal nerve stimulation, i.e. VNS). The author has attempted to search for a novel alternative (drug-regime) approach to its management to minimise any invasive technique or surger...

journal_title：Medical hypotheses

authors： Jaseja H

更新日期：2003-08-01 00:00:00

abstract：:Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. ...

journal_title：Medical hypotheses

authors： Brenner SR

更新日期：2017-05-01 00:00:00

abstract：:An expansion of the 'stable' gene hypothesis proposed previously is the hypothesis that there is a range of genes, some proto-oncogenes and some not, varying from those with multiple copies in the genome, wide distribution among species, and limited mutability because of a specific protective stabilizing mechanism of ...

journal_title：Medical hypotheses

authors： Frei JV

更新日期：1995-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary tumor of liver and its incidence continues to increase worldwide. HCC is a disease with multifactorial causes and genetic variability has been discussed as a risk factor for its development. Liver is a hormone-sensitive organ and therefore is influenced by gona...

journal_title：Medical hypotheses

authors： Baldissera VD,Alves AF,Almeida S,Porawski M,Giovenardi M

更新日期：2016-01-01 00:00:00

abstract：:Invasive carcinoma originates from the epithelial cells lining the lumen of an organ. It is often preceded by metaplasia, dysplasia or carcinoma in situ. The purpose of this review is to suggest that this disease of the epithelium may be, in part, the result of underlying tissue-based disorganization. Human cancer is ...

journal_title：Medical hypotheses

authors： Schwartz L,Balosso J,Baillet F,Brun B,Amman JP,Sasco AJ

更新日期：2002-04-01 00:00:00

abstract：:Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of Vitamin K on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of Vitamin K overlap with key brain development aberration...

journal_title：Medical hypotheses

authors： DeSoto MC

更新日期：2016-11-01 00:00:00

abstract：:The largely empirical dopamine theory has limited value in clarifying the pathogenesis of schizophrenia, due to its inability to explain consistent imaging findings, such as cortical grey matter loss, reduced frontal and thalamic activity, and, reduced D1 receptor load. Furthermore, the most effective drug for treatin...

journal_title：Medical hypotheses

authors： McDermott E,de Silva P

更新日期：2005-01-01 00:00:00

abstract：:Preliminary reports have demonstrated that anterior nucleus thalamus high-frequency electrical stimulation (ANT-HFS) is an effective treatment for patients who suffer from medically refractory epilepsy. However, its extensive application has been hampered by the high cost and the unpredictable outcome before the opera...

journal_title：Medical hypotheses

authors： Yan N,Chen N,Lu J,Wang Y,Wang W

更新日期：2013-09-01 00:00:00

abstract：:Both human cell lines HL-60 and AML-193 exhibit a myeloblastic and promyelocytic morphology, respectively, but may be regarded as bipotent leukemic precursors. They can be triggered to differentiate to either granulocytes or monocytes upon retinoic acid (RA) or 1,25-dihydroxyvitamin D (D3) addition, respectively. We h...

journal_title：Medical hypotheses

authors： Camagna A,Testa U,Masciulli R,Barberi T,Samoggia P,Tritarelli E,Pustorino E,Cipollone L,Ciancio L,del Duca P,Dionisi S,del Vecchio LR,Misasi G,de Martinis C,Peschle C

更新日期：1998-03-01 00:00:00

abstract：:Vagus nerve stimulation (VNS) and electroacupuncture (EA) at specific acupoints have both shown promising anticonvulsant effects in intractable epilepsy patients. The differences between these therapies are target selection and stimulation parameter modulation. It has been demonstrated that EA of the extremities resul...

journal_title：Medical hypotheses

authors： Chen N,Zhang H,Gao XD,Yan N,Ma Y,Yu CJ

更新日期：2013-12-01 00:00:00

abstract：:Fetal death recurrence is an important problem in reproductive health that is poorly understood. Based on preliminary epidemiologic evidence, we propose an "event memory" hypothesis which posits that when fetal death occurs the event is retained (memorized) as a program that is replayed in future pregnancies. We descr...

journal_title：Medical hypotheses

authors： Salihu HM

更新日期：2008-01-01 00:00:00

abstract：:Hyperplasia of the coronoid process of the mandible has been observed in conditions like Oral submucous fibrosis, TMJ ankylosis, etc. The etiopathogenesis of this coronoid overgrowth has not been clearly sequenced or adequately hypothesized, and no definite mechanism has so far been advocated to explain this elongatio...

journal_title：Medical hypotheses

authors： Chakranarayan A,Jeyaraj P

更新日期：2011-11-01 00:00:00

abstract：:Historically, cluster reports have been considered to be only marginally productive and generally discouraged as statistical artifacts. This report presents the results of a three year study involving in excess of 100 cancer cluster reports. The majority of these investigations represented statistical events; there we...

journal_title：Medical hypotheses

authors： Aldrich TE,Garcia N,Ziechner S,Berger S

更新日期：1983-09-01 00:00:00

abstract：:The essential trace element selenium is known to be capable of reducing the toxicity of heavy metals like cadmium(II), mercury(II) and silver(I). One mechanism by which this occurs is through the formation of an inert metal selenide like silver selenide. It is not clear why selenide should react in the body preferenti...

journal_title：Medical hypotheses

authors： Nuttall KL

更新日期：1987-10-01 00:00:00

abstract：:The biology of natural selection is an enduring mystery, as is the nature of Charles Darwin's chronic illness. Of the theories advanced to explain the latter, Oedipal conflicts and Chagas' disease are preeminent. Hypomania, however, propelled Darwin to the pinnacle of scientific achievement and good health, the depres...

journal_title：Medical hypotheses

authors： Lieb J

更新日期：2007-01-01 00:00:00

abstract：:S-allylgutimine has immunostimulant and tumor cell inhibitory activities. This complex action may be a result of the stimulation of IL-2 production. The effectiveness of immunotherapy depends on the uncoupling of IL-2 downregulation. This principle can be widely used with those immunological diseases where IL-2 level ...

journal_title：Medical hypotheses

authors： Vértesi C

更新日期：1993-06-01 00:00:00

abstract：:The prevailing view of lung cancer is multi-step progression of normal cells into cancer cells through gain of function oncogenes coupled with loss of tumor suppressor genes. This progression of genetic damage ultimately results in the hallmarks of cancer. This theory has strong support from studies finding genetic da...

journal_title：Medical hypotheses

authors： Haura EB

更新日期：2006-01-01 00:00:00

abstract：:Cancer is caused by a combination of factors, genetic, epigenetics and environmental. Among the latter, environmental pollutants absorbed by contact, inhalation, or ingestion are major proven or suspected culprits. Depleted uranium (DU) is one of them directly pertinent to the military and civilians working in militar...

journal_title：Medical hypotheses

authors： Cappello F,Macario AJL

更新日期：2019-03-01 00:00:00