Abstract：
:Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. Other Neurological degenerative diseases with potential nutritional components such as Parkinson's disease, frailty of age and Multiple Sclerosis, a disease with increased activity from vitamin D deficiency, may also be related to untreated exocrine pancreatic insufficiency causing impaired absorption of essential dietary elements. Testing of patients with Neurological degenerative diseases for EPI may enable correction of underlying nutritional deficiencies with enzyme replacement as necessary, possibly resulting in improvement of the underlying Neurological condition.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Brenner SRdoi
10.1016/j.mehy.2017.03.020subject
Has Abstractpub_date
2017-05-01 00:00:00pages
89-90eissn
0306-9877issn
1532-2777pii
S0306-9877(16)30528-Xjournal_volume
102pub_type
杂志文章abstract：:Dysbiosis is a prominent feature of inflammatory bowel diseases (IBD). However, the efficacy of using antibiotics aiming at the aberrant gut microflora for IBD treatment are either unsuccessful or not persistent. In contrast, long-term oral vancomycin has been proved effective in controlling both the bile duct and gut...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110211
更新日期：2020-11-01 00:00:00
abstract：:Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a numb...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.03.010
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109869
更新日期：2020-10-01 00:00:00
abstract：:Chronic stresses can induce physiological and psychological changes and result in stress-related neuropsychiatry, sometimes they may also contribute to hypersensitivity to pain known as stress-induced hyperalgesia (SIH). Recently it was found that GABAergic disinhibition is closely related to morphine and chronic infl...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.10.008
更新日期：2014-12-01 00:00:00
abstract：:Breast and ovarian cancer rates in Pakistan are significantly higher than in neighboring countries. The cancer rate discrepancies cannot be explained with discrepancies of their risk factors. We propose that observed cancer excess in Pakistan is due to cancer development by negative heterosis. Heterosis occurs when a ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.10.013
更新日期：2005-01-01 00:00:00
abstract：:We describe here a new technique for analyzing human growth curves using a first order kinetic representation. Plotting in ([h infinity-ht)/h infinity] vs time (where h infinity and ht represent the final and instantaneous heights) transforms growth curves into 3 linear phases and 2 interphases. These growth parameter...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(85)90073-8
更新日期：1985-02-01 00:00:00
abstract：:An observation of sleep improvement with vitamin D supplementation led to a 2 year uncontrolled trial of vitamin D supplementation in 1500 patients with neurologic complaints who also had evidence of abnormal sleep. Most patients had improvement in neurologic symptoms and sleep but only through maintaining a narrow ra...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.03.031
更新日期：2012-08-01 00:00:00
abstract：:Herbs and minerals are the integral parts of traditional systems of medicine in many countries. Kushta is a form of herbo-mineral preparations used in traditional systems of medicine (Unani and Ayurvedic) of Indo-Pak subcontinent. These preparations have long been used and claimed to be the most effective and potent d...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00260-8
更新日期：2002-10-01 00:00:00
abstract：:Recurrent aphthous ulcer (RAU) is the most common ulcer of oral non-keratinized mucosa, but the treatment is always limited at present. Considering the multifactorial etiology of RAU, a novel therapeutic agent with multi-bioactivties should be presented. Garlic has been recognized as a favorable natural medicine again...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.07.028
更新日期：2008-12-01 00:00:00
abstract：:Acute renal failure (ARF) is a rapid loss of kidney function. The reasons and mechanism by which this occurs has not been clarified so far thus creating obstacles to management of this disease. Presently, the experimental research using the accepted renal ischemia reperfusion injury (I/R injury) model represented for ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.12.041
更新日期：2013-04-01 00:00:00
abstract：:Mild traumatic brain injury, often referred to as concussion, is a common, potentially debilitating, and costly condition. One of the main challenges in diagnosing and managing concussion is that there is not currently an objective test to determine the presence of a concussion and to guide return-to-play decisions fo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.05.012
更新日期：2015-09-01 00:00:00
abstract：:Reversing chronic conditions remains an elusive goal of medicine. The modern medical paradigm based on blocking overactive pathways or augmenting deficient pathways offers symptomatic benefit, but tolerance to therapy can develop and treatment cessation can produce rebound symptoms due to compensatory mechanisms. We p...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.09.007
更新日期：2005-01-01 00:00:00
abstract：:N-acetylaspartate (NAA) is an intermediary metabolite that is found in relatively high concentrations in the human brain. More specifically, NAA is so concentrated in the neurons that it generates one of the most visible peaks in nuclear magnetic resonance (NMR) spectra, thus allowing NAA to serve as "a neuronal marke...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.02.047
更新日期：2006-01-01 00:00:00
abstract：:We have observed a distinct difference in the alpha-fetoprotein production of Sprague-Dawley rats and Swiss white mice. When both animals are fed a 1% D/L-ethionine diet, only the rat responds with increased levels of hepatic alpha-fetoprotein synthesis as shown by radioimmunoassay studies. Also, hybridization studies...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(82)90083-4
更新日期：1982-10-01 00:00:00
abstract：:The major thesis of the proposed hypothesis is that in the absence of microbial material synovial macrophages in rheumatoid arthritis patients continue to release interleukin 1, which perpetuates the inflammation so characteristic of the disease. Its release is suggested to result from an altered synovial macrophage g...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(82)90084-6
更新日期：1982-10-01 00:00:00
abstract：:Autism is a severe developmental disability believed to have multiple etiologies. This paper outlines the possibility of a subacute, chronic tetanus infection of the intestinal tract as the underlying cause for symptoms of autism observed in some individuals. A significant percentage of individuals with autism have a ...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/s0306-9877(98)90107-4
更新日期：1998-08-01 00:00:00
abstract：:Injury and organ failure after irradiation of late-responding tissues is a substantial problem in radiation oncology and a major threat after accidental or belligerent exposures. The mechanisms of injury may include death of clonogens, vascular injury, activation of cytokine networks, and/or chronic oxidative stress. ...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2012.11.022
更新日期：2013-02-01 00:00:00
abstract：:The modern living standard has imposed upon society a situation of chronic sleep deprivation. This chronic loss of sleep affects women more than it does men. As a result, the postponement of pregnancy has become a common choice due to the priority given to social and domestic activities. For women, pregnancy represent...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.07.036
更新日期：2010-12-01 00:00:00
abstract：:Spinocerebellar ataxia type 2 (SCA2) is caused by a CAG trinucleotide repeat expansion within the coding region of the ataxin-2 gene. Affected individuals typically have between 34 and 57 CAG repeats. Signs of the disorder generally begin in adulthood and include progressive ataxia, dysarthria, tremor, hyporeflexia, a...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.03.046
更新日期：2004-01-01 00:00:00
abstract：:The article introduces the hypothesis that aquaporin 1 of intramuscular capillary endothelial cells may enhance the capability of the skeletal myofiber regeneration. Evidence for the hypothesis is based on the indication obtained from our previous muscle xenograft study into athymic nude mice, and the indications prop...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.07.056
更新日期：2007-01-01 00:00:00
abstract：:This article proposes a series of experiments to determine if cows and sheep could be used as animal models for HIV-1, the AIDS virus. To justify this effort, a substantial case is presented that HIV-1 is a natural recombinant of Bovine Leukemia Virus (BLV) and Visna Virus. This natural recombinant may have been inadv...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90069-3
更新日期：1993-10-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.04.013
更新日期：2019-06-01 00:00:00
abstract：:Treatment for stuttering attempts to reduce or eliminate the observable core markers of the disorder, specifically repetitions and prolongation. In this hypothesis, it is proposed that stuttering may be inhibited by two distinct yet related procedures: active inhibition and passive inhibition. Active inhibition is bro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1452
更新日期：2002-01-01 00:00:00
abstract：:Pulmonary hypertension (PH) is defined as elevated mean pulmonary artery pressure secondary to e.g. congenital heart disease and chronic obstructive pulmonary disease. It elevates right ventricular afterload that eventually leads to cor pulmonale and right heart failure. Experimental research has shown that cardioprot...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109572
更新日期：2020-04-01 00:00:00
abstract：:The paper proposes a mechanism for regulating nucleo-cytoplasmic exchanges of macromolecules via NPC in vertebrates. Bending of NE toward the transport vector significantly contributes to the dynamics. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1998.0813
更新日期：2000-01-01 00:00:00
abstract：:Cancer stem cells are a small population of tumor cells that have many malignant features such as chemotherapy resistance, radiotherapy resistance, tumorigenicity and are responsible for tumor progression, disease recurrence and metastasis. Therefore, insight into the regulation of the biology of cancer stem cells is ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.12.016
更新日期：2013-04-01 00:00:00
abstract：:The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.02.046
更新日期：2009-11-01 00:00:00
abstract：:Chronic active Epstein-Barr virus (EBV) infection has been recognized as clonal non-neoplastic lymphoproliferative diseases. However, some reports of cases with a multiphenotypic expansion of EBV-infected lymphocytes give rise to questions of how EBV infects multiphenotypic lymphocytes and whether chronic active EBV i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.03.012
更新日期：2004-01-01 00:00:00
abstract：:Developmental alcohol exposure adversely influences the developing brain. Alcohol exposure during rapid brain growth causes cell loss, alters connections between brain regions, and lowers the production of biological substances responsible for the communication among neurons. It is reasonable to suggest that alcohol m...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.021
更新日期：2004-01-01 00:00:00
abstract：:Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.01.026
更新日期：2005-01-01 00:00:00
