Alzheimer's disease and other neurodegenerative diseases may be due to nutritional deficiencies secondary to unrecognized exocrine pancreatic insufficiency.


:Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. Other Neurological degenerative diseases with potential nutritional components such as Parkinson's disease, frailty of age and Multiple Sclerosis, a disease with increased activity from vitamin D deficiency, may also be related to untreated exocrine pancreatic insufficiency causing impaired absorption of essential dietary elements. Testing of patients with Neurological degenerative diseases for EPI may enable correction of underlying nutritional deficiencies with enzyme replacement as necessary, possibly resulting in improvement of the underlying Neurological condition.


Med Hypotheses


Medical hypotheses


Brenner SR




Has Abstract


2017-05-01 00:00:00












  • Long-term oral vancomycin for refractory inflammatory bowel diseases without Clostridium difficile infection: Lessons from primary sclerosing cholangitis.

    abstract::Dysbiosis is a prominent feature of inflammatory bowel diseases (IBD). However, the efficacy of using antibiotics aiming at the aberrant gut microflora for IBD treatment are either unsuccessful or not persistent. In contrast, long-term oral vancomycin has been proved effective in controlling both the bile duct and gut...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Du W,Han W,Dong J

    更新日期:2020-11-01 00:00:00

  • Glutathione sodium salt as a novel adjunctive treatment for acute myocardial infarction.

    abstract::Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a numb...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Truscelli G,Tanzilli G,Viceconte N,Dominici M,Arrivi A,Sommariva L,Granatelli A,Gaudio C,Mangieri E

    更新日期:2017-05-01 00:00:00

  • Are consumers satisfied with the use of prosthetic sports feet and the provision process? A mixed-methods study.

    abstract:BACKGROUND:Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Poonsiri J,van Putten SWE,Ausma AT,Geertzen JHB,Dijkstra PU,Dekker R

    更新日期:2020-10-01 00:00:00

  • BDNF-trkB-KCC2-GABA pathway may be related to chronic stress-induced hyperalgesia at both the spinal and supraspinal level.

    abstract::Chronic stresses can induce physiological and psychological changes and result in stress-related neuropsychiatry, sometimes they may also contribute to hypersensitivity to pain known as stress-induced hyperalgesia (SIH). Recently it was found that GABAergic disinhibition is closely related to morphine and chronic infl...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Dai S,Ma Z

    更新日期:2014-12-01 00:00:00

  • Cancer by negative heterosis: breast and ovarian cancer excess in hybrids of inbred ethnic groups.

    abstract::Breast and ovarian cancer rates in Pakistan are significantly higher than in neighboring countries. The cancer rate discrepancies cannot be explained with discrepancies of their risk factors. We propose that observed cancer excess in Pakistan is due to cancer development by negative heterosis. Heterosis occurs when a ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Denic S,Khatib F,Awad M,Karbani G,Milenkovic J

    更新日期:2005-01-01 00:00:00

  • Linearization of human growth curves affords new classification of dwarfism.

    abstract::We describe here a new technique for analyzing human growth curves using a first order kinetic representation. Plotting in ([h infinity-ht)/h infinity] vs time (where h infinity and ht represent the final and instantaneous heights) transforms growth curves into 3 linear phases and 2 interphases. These growth parameter...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Schreiber G,Baron B

    更新日期:1985-02-01 00:00:00

  • The world epidemic of sleep disorders is linked to vitamin D deficiency.

    abstract::An observation of sleep improvement with vitamin D supplementation led to a 2 year uncontrolled trial of vitamin D supplementation in 1500 patients with neurologic complaints who also had evidence of abnormal sleep. Most patients had improvement in neurologic symptoms and sleep but only through maintaining a narrow ra...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Gominak SC,Stumpf WE

    更新日期:2012-08-01 00:00:00

  • Kushta(s): unique herbo-mineral preparations used in South Asian traditional medicine.

    abstract::Herbs and minerals are the integral parts of traditional systems of medicine in many countries. Kushta is a form of herbo-mineral preparations used in traditional systems of medicine (Unani and Ayurvedic) of Indo-Pak subcontinent. These preparations have long been used and claimed to be the most effective and potent d...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Aziz N,Gilani AH,Rindh MA

    更新日期:2002-10-01 00:00:00

  • A new therapeutic candidate for oral aphthous ulcer: Allicin.

    abstract::Recurrent aphthous ulcer (RAU) is the most common ulcer of oral non-keratinized mucosa, but the treatment is always limited at present. Considering the multifactorial etiology of RAU, a novel therapeutic agent with multi-bioactivties should be presented. Garlic has been recognized as a favorable natural medicine again...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Jiang XW,Hu J,Mian FI

    更新日期:2008-12-01 00:00:00

  • A novel mechanism of NALP3 inducing ischemia reperfusion injury by activating MAPK pathway in acute renal failure.

    abstract::Acute renal failure (ARF) is a rapid loss of kidney function. The reasons and mechanism by which this occurs has not been clarified so far thus creating obstacles to management of this disease. Presently, the experimental research using the accepted renal ischemia reperfusion injury (I/R injury) model represented for ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hao JL,Li YF,Li RS

    更新日期:2013-04-01 00:00:00

  • Can a combination of ultrasonographic parameters accurately evaluate concussion and guide return-to-play decisions?

    abstract::Mild traumatic brain injury, often referred to as concussion, is a common, potentially debilitating, and costly condition. One of the main challenges in diagnosing and managing concussion is that there is not currently an objective test to determine the presence of a concussion and to guide return-to-play decisions fo...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Cartwright MS,Dupuis JE,Bargoil JM,Foster DC

    更新日期:2015-09-01 00:00:00

  • Paradoxical strategy for treating chronic diseases where the therapeutic effect is derived from compensatory response rather than drug effect.

    abstract::Reversing chronic conditions remains an elusive goal of medicine. The modern medical paradigm based on blocking overactive pathways or augmenting deficient pathways offers symptomatic benefit, but tolerance to therapy can develop and treatment cessation can produce rebound symptoms due to compensatory mechanisms. We p...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Yun AJ,Lee PY,Bazar KA

    更新日期:2005-01-01 00:00:00

  • N-acetylaspartate as a reservoir for glutamate.

    abstract::N-acetylaspartate (NAA) is an intermediary metabolite that is found in relatively high concentrations in the human brain. More specifically, NAA is so concentrated in the neurons that it generates one of the most visible peaks in nuclear magnetic resonance (NMR) spectra, thus allowing NAA to serve as "a neuronal marke...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Clark JF,Doepke A,Filosa JA,Wardle RL,Lu A,Meeker TJ,Pyne-Geithman GJ

    更新日期:2006-01-01 00:00:00

  • Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: X. Correlation of the induceability of hepatomas and alpha-fetoprotein gene activity.

    abstract::We have observed a distinct difference in the alpha-fetoprotein production of Sprague-Dawley rats and Swiss white mice. When both animals are fed a 1% D/L-ethionine diet, only the rat responds with increased levels of hepatic alpha-fetoprotein synthesis as shown by radioimmunoassay studies. Also, hybridization studies...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Payette R,Hancock RL

    更新日期:1982-10-01 00:00:00

  • Etiology of rheumatoid arthritis.

    abstract::The major thesis of the proposed hypothesis is that in the absence of microbial material synovial macrophages in rheumatoid arthritis patients continue to release interleukin 1, which perpetuates the inflammation so characteristic of the disease. Its release is suggested to result from an altered synovial macrophage g...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Rafter GW

    更新日期:1982-10-01 00:00:00

  • Autism and Clostridium tetani.

    abstract::Autism is a severe developmental disability believed to have multiple etiologies. This paper outlines the possibility of a subacute, chronic tetanus infection of the intestinal tract as the underlying cause for symptoms of autism observed in some individuals. A significant percentage of individuals with autism have a ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审


    authors: Bolte ER

    更新日期:1998-08-01 00:00:00

  • Chronic oxidative stress after irradiation: An unproven hypothesis.

    abstract::Injury and organ failure after irradiation of late-responding tissues is a substantial problem in radiation oncology and a major threat after accidental or belligerent exposures. The mechanisms of injury may include death of clonogens, vascular injury, activation of cytokine networks, and/or chronic oxidative stress. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审


    authors: Cohen SR,Cohen EP

    更新日期:2013-02-01 00:00:00

  • Sleep impairment during pregnancy: possible implications on mother-infant relationship.

    abstract::The modern living standard has imposed upon society a situation of chronic sleep deprivation. This chronic loss of sleep affects women more than it does men. As a result, the postponement of pregnancy has become a common choice due to the priority given to social and domestic activities. For women, pregnancy represent...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Pires GN,Andersen ML,Giovenardi M,Tufik S

    更新日期:2010-12-01 00:00:00

  • Can ataxin-2 be down-regulated by allele-specific de novo DNA methylation in SCA2 patients?

    abstract::Spinocerebellar ataxia type 2 (SCA2) is caused by a CAG trinucleotide repeat expansion within the coding region of the ataxin-2 gene. Affected individuals typically have between 34 and 57 CAG repeats. Signs of the disorder generally begin in adulthood and include progressive ataxia, dysarthria, tremor, hyporeflexia, a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Bauer PO,Zumrova A,Matoska V,Mitsui K,Goetz P

    更新日期:2004-01-01 00:00:00

  • Skeletal muscle regeneration may be enhanced by overexpression of aquaporin 1 in intramuscular capillary endothelial cells.

    abstract::The article introduces the hypothesis that aquaporin 1 of intramuscular capillary endothelial cells may enhance the capability of the skeletal myofiber regeneration. Evidence for the hypothesis is based on the indication obtained from our previous muscle xenograft study into athymic nude mice, and the indications prop...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Wakayama Y

    更新日期:2007-01-01 00:00:00

  • The origin of HIV-1, the AIDS virus.

    abstract::This article proposes a series of experiments to determine if cows and sheep could be used as animal models for HIV-1, the AIDS virus. To justify this effort, a substantial case is presented that HIV-1 is a natural recombinant of Bovine Leukemia Virus (BLV) and Visna Virus. This natural recombinant may have been inadv...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Siefkes D

    更新日期:1993-10-01 00:00:00

  • Preclinical signs of Parkinson's disease: A possible association of Parkinson's disease with skin and hair features.

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder, characterized by loss of dopaminergic neuromelanin containing neurons in the substantia nigra. Peripheral melanin, found in skin and hair, and neuromelanin appear to have some characteristics in common and share the same precursor for their synthesis; therefore...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Jucevičiūtė N,Banaitytė I,Vaitkus A,Balnytė R

    更新日期:2019-06-01 00:00:00

  • Reduction of stuttering: the dual inhibition hypothesis.

    abstract::Treatment for stuttering attempts to reduce or eliminate the observable core markers of the disorder, specifically repetitions and prolongation. In this hypothesis, it is proposed that stuttering may be inhibited by two distinct yet related procedures: active inhibition and passive inhibition. Active inhibition is bro...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Saltuklaroglu T,Dayalu VN,Kalinowski J

    更新日期:2002-01-01 00:00:00

  • Making a case for metallothioneins conferring cardioprotection in pulmonary hypertension.

    abstract::Pulmonary hypertension (PH) is defined as elevated mean pulmonary artery pressure secondary to e.g. congenital heart disease and chronic obstructive pulmonary disease. It elevates right ventricular afterload that eventually leads to cor pulmonale and right heart failure. Experimental research has shown that cardioprot...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Maarman GJ

    更新日期:2020-04-01 00:00:00

  • Mechanics of nucleocytoplasmic exchanges mediated by vertebrates' nuclear pore complex.

    abstract::The paper proposes a mechanism for regulating nucleo-cytoplasmic exchanges of macromolecules via NPC in vertebrates. Bending of NE toward the transport vector significantly contributes to the dynamics. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Matioli GT

    更新日期:2000-01-01 00:00:00

  • The correlation of hematopoietic stem cells with cancer stem cells through the regulation of stromal cells in tumor microenvironment.

    abstract::Cancer stem cells are a small population of tumor cells that have many malignant features such as chemotherapy resistance, radiotherapy resistance, tumorigenicity and are responsible for tumor progression, disease recurrence and metastasis. Therefore, insight into the regulation of the biology of cancer stem cells is ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lin S,Fu S

    更新日期:2013-04-01 00:00:00

  • Three-dimensional spring model: a new hypothesis of pathogenesis of adolescent idiopathic scoliosis.

    abstract::The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Yang Z,Xie Y,Li M

    更新日期:2009-11-01 00:00:00

  • Clonal expansion of multiphenotypic Epstein-Barr virus-infected lymphocytes in chronic active Epstein-Barr virus infection.

    abstract::Chronic active Epstein-Barr virus (EBV) infection has been recognized as clonal non-neoplastic lymphoproliferative diseases. However, some reports of cases with a multiphenotypic expansion of EBV-infected lymphocytes give rise to questions of how EBV infects multiphenotypic lymphocytes and whether chronic active EBV i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Endo R,Yoshioka M,Ebihara T,Ishiguro N,Kikuta H,Kobayashi K

    更新日期:2004-01-01 00:00:00

  • Etiology, pathogenesis, and treatment of seasonal and non-seasonal mood disorders: possible role of circadian rhythm abnormalities related to developmental alcohol exposure.

    abstract::Developmental alcohol exposure adversely influences the developing brain. Alcohol exposure during rapid brain growth causes cell loss, alters connections between brain regions, and lowers the production of biological substances responsible for the communication among neurons. It is reasonable to suggest that alcohol m...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sher L

    更新日期:2004-01-01 00:00:00

  • 5-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin.

    abstract::Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhi...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Turner EH,Blackwell AD

    更新日期:2005-01-01 00:00:00