Abstract:
:Cancer is caused by a combination of factors, genetic, epigenetics and environmental. Among the latter, environmental pollutants absorbed by contact, inhalation, or ingestion are major proven or suspected culprits. Depleted uranium (DU) is one of them directly pertinent to the military and civilians working in militarized areas. It is considered a weak carcinogen but its implication in cancer development in exposed individuals is supported by various data. Since not all subjects exposed to DU develop cancer, it is likely that DU-dependent carcinogenesis requires cofactors, such as genetic predisposition and deficiencies of the chaperoning and immune systems. It is of the essence to adopt every possible protective measure as well as performing careful screening for early diagnosis to protect the military that work in war areas in which weapons with DU are, or have been, used. These topics are discussed here, along with a proposed working hypothesis for investigating the pathophysiology of DU-related carcinogenesis, including the possible role of the chaperoning system.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Cappello F,Macario AJLdoi
10.1016/j.mehy.2019.01.018subject
Has Abstractpub_date
2019-03-01 00:00:00pages
26-30eissn
0306-9877issn
1532-2777pii
S0306-9877(18)31194-0journal_volume
124pub_type
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journal_title:Medical hypotheses
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