Embryonic and fetal cells which are not diseased or defective; possible sources of genes for disease prevention or treatment.

abstract：:Open-angle glaucoma, idiopathic intracranial hypertension, and Meniere's disease are disorders managed by different specialties in medicine viz. ophthalmology, neurology, and otorhinolaryngology respectively. By working in silos, the similarity of these disorders is overlooked. Close inspection of these disorders reve...

journal_title：Medical hypotheses

authors： Moodley A,Van Der Meyden K

更新日期：2019-11-01 00:00:00

abstract：:In this work some aspects of carcinogenesis are given. The importance of the emergence of Z or H DNA structure in the gene, or in the flanking gene sequences for the gene deletion and unusual gene recombination, is discussed. Some considerations on the role of selective pressure (of polyamines, of Mg2+, of the various...

journal_title：Medical hypotheses

authors： Juranic Z,Kidric M,Tomin R,Juranić I,Spuzić I,Petrović J

更新日期：1991-08-01 00:00:00

abstract：:HIV may induce subclinical neuroendocrine dysfunctions in some seropositive patients and these dysfunctions may be one of the co-factors that determine the pathogenesis of AIDS. ...

journal_title：Medical hypotheses

authors： Salomon JC

更新日期：1988-09-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPR...

journal_title：Medical hypotheses

authors： Varadarajan S,Balaji TM,Sarode SC,Sarode GS,Sharma NK,Gondivkar S,Gadbail A,Patil S

更新日期：2020-10-01 00:00:00

abstract：:Gas formed in tissues and the circulating blood due to decompression is thought to be a significant factor in the progression of decompression illness (DCI). DCI is a potential problem for a growing population of professional and recreational divers. We hypothesise that these gas bubbles are not the causative agent in...

journal_title：Medical hypotheses

authors： Madden LA,Laden G

更新日期：2009-04-01 00:00:00

abstract：:Too small size at birth (due to poor fetal growth and/or preterm delivery) has been associated with substantially elevated risks of the metabolic syndrome (dislipidemia, insulin resistance, hypertension), type 2 diabetes and cardiovascular disease in adulthood. The mechanisms of such "fetal origins" or "programming" o...

journal_title：Medical hypotheses

authors： Luo ZC,Fraser WD,Julien P,Deal CL,Audibert F,Smith GN,Xiong X,Walker M

更新日期：2006-01-01 00:00:00

abstract：:Trigeminal neuralgia (TN) is a rare form of neuropathic pain that results in sudden, unilateral and recurrent pains in the distribution of one or more branches of the trigeminal nerve. The aetiology of TN remains unclear and several theories have been proposed. Many medical and surgical methods have been applied with ...

journal_title：Medical hypotheses

authors： Collet C,Haen P,Laversanne S,Brignol L,Thiéry G

更新日期：2013-12-01 00:00:00

abstract：:Being born in the winter and spring significantly increases one's risk for developing schizophrenia. This birth seasonality may account for as many as 10% of all cases of schizophrenia. Maternal third trimester infections or vitamin D deficiencies are hypothesized to be the most likely cause and can account for many o...

journal_title：Medical hypotheses

authors： Schwartz PJ

更新日期：2011-06-01 00:00:00

abstract：:Late luteal phase dysphoric disorder is described as a classic biopsychosocial disorder resulting from complex interactions of biological, psychological, socioeconomic and cultural forces on women. To understand women suffering from the disorder, one must understand how the genetically designed female brain and body i...

journal_title：Medical hypotheses

authors： Severino SK

更新日期：1993-09-01 00:00:00

abstract：:In both African AIDS populations and homosexual populations outside of Africa, a high incidence of syphilis and multiple exposures to infectious diseases results in frequent, often abusive use of antibiotics. Epidemiological evidence exists for chemical immunosuppression resulting from antibiotics and other prescribed...

journal_title：Medical hypotheses

authors： McKenna JJ,Miles R,Lemen D,Dunford SA,Renirie R

更新日期：1986-12-01 00:00:00

abstract：:A primary goal in antimicrobial drug design is to find molecules which inhibit key proteins in bacteria without affecting mammalian homologues. To this aim, structural differences between eukaryotic and prokaryotic enzyme proteins involved in life processes are widely exploited. The membrane-bound enzyme complex ATP s...

journal_title：Medical hypotheses

authors： Nesci S,Ventrella V,Trombetti F,Pirini M,Pagliarani A

更新日期：2014-08-01 00:00:00

abstract：:The number of deaths per year from hepatocellular carcinoma (HCC) exceeds 250000, placing it sixth as the cause of death from cancer worldwide. The primary etiology of most cases of HCC in the US is hepatitis B and/or C. Extensive research has demonstrated that the relationship between hepatitis B infection and the pr...

journal_title：Medical hypotheses

authors： Steel J,Carney M,Carr BI,Baum A

更新日期：2004-01-01 00:00:00

abstract：:A hypothesis is proposed here to reconcile the inconsistencies observed in the IQ-P3 latency relation. The hypothesis stems from the observation that task-induced increase in P3 latency correlates positively with IQ scores. It is hypothesised that: (a) there are several parallel information processing pathways of vary...

journal_title：Medical hypotheses

authors： Sircar SS

更新日期：2000-06-01 00:00:00

abstract：:This hypothesis named Salerian Addictive Potential (SAP) suggests that the addictive potency of any substance may be calculated with an algebraic equation of A=E/T(max)xt(1/2), where A is the addictive potency, E represents the euphoric potency, T(max) is the time to reach peak plasma concentration, and t(1/2) is the ...

journal_title：Medical hypotheses

authors： Salerian AJ

更新日期：2010-06-01 00:00:00

abstract：:Preeclampsia (PE) and gestational diabetes mellitus (GDM) are two of the most common medical complications of pregnancy, with risks for both mother and child. Like many other antepartum complications, PE and GDM occur only in pregnancy. However, it is not clear if pregnancy itself is the cause of these complications o...

journal_title：Medical hypotheses

authors： Wen SW,Xie RH,Tan H,Walker MC,Smith GN,Retnakaran R

更新日期：2012-07-01 00:00:00

abstract：:Parathyroid hormone (PTH) acts as a controller of bone remodeling and has influence on periodontal tissues. In addition to the well-established catabolic effects (activation of bone resorption) of PTH, it is recognized that the PTH intermittent administration has anabolic effects (promotion of bone formation). However...

journal_title：Medical hypotheses

authors： Vasconcelos DF,Vasconcelos AC

更新日期：2016-03-01 00:00:00

abstract：:Genetic and environmental influences are both known to be causal factors in the development and maintenance of obesity. Stress related chronic stimulation of the hypothalamic-pituitary-adrenal (HPA) axis and resulting increased glucocorticoid exposure are known to be important pathophysiological mechanisms in the deve...

journal_title：Medical hypotheses

authors： Mutschler J,Kiefer F

更新日期：2011-03-01 00:00:00

abstract：:As a type of primary open-angle glaucoma, normal-tension glaucoma (NTG) is a health problem that manifests itself with low intraocular pressure (IOP) levels and preserves its importance for public health care. In population-based screenings, which take the IOP levels of 21mmHg as a cut-off for the diagnosis of glaucom...

journal_title：Medical hypotheses

authors： Atalay K,Kaldirim Erdogan H,Kirgiz A,Asik Nacaroglu S

更新日期：2017-06-01 00:00:00

abstract：:Chronic Interstitial Nephritis in Agricultural Communities (CINAC) continues to attract controversy in the scientific community. It was previously known as Chronic Kidney Disease of Unknown Etiology (CKDu) and is not associated with the common aetiological factors such as diabetes. There is general acceptance that it ...

journal_title：Medical hypotheses

authors： Rodrigo C,Nawarathne P,Jayasinghe S

更新日期：2021-01-01 00:00:00

abstract：:Growing evidence has indicated the existence of deleterious networks in the brains of neurodegenerative disorders, including Alzheimer's disease. Parkinson's disease, amyotrophic lateral sclerosis and Huntington's disease. The deleterious networks are formed on the basis of the intimate interactions among the key path...

journal_title：Medical hypotheses

authors： Ying W

更新日期：1996-10-01 00:00:00

abstract：:Over-degradation of extracellular components by matrix metalloproteinases (MMPs) has been implicated as an important characteristic during the pathological evolution of the abdominal aortic aneurysm (AAA) and cerebral aneurysm (CA), which contribute to progressive dilation of vascular wall. However, mRNA and protein e...

journal_title：Medical hypotheses

authors： Zhou X,Ji WJ,Tu Y,Yao M,Li YM

更新日期：2007-01-01 00:00:00

abstract：:Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control effor...

journal_title：Medical hypotheses

authors： Mao F,Chen T,Zhao Y,Zhang C,Bai B,Zhao S,Xu Z,Shi C

更新日期：2011-07-01 00:00:00

abstract：:In this editorial, we provide concise suggestions to help individuals decide what scientific papers to read and how to read them. We do so because--like others--we are frequently asked by people with interest in science as to how to effectively surf today's information tsunami. This is particularly important in, but n...

journal_title：Medical hypotheses

authors： Erren TC,Cullen P,Erren M

更新日期：2009-09-01 00:00:00

abstract：:The authors hypothesize that the impairment of hypothalamic-pituitary-gonadal axis in patients suffering from anorexia nervosa depends (at least in part) on the increased sensitivity to endogenous melatonin. The hypothesis is based mainly on the following facts: (1) melatonin is well known to exert an inhibitory effec...

journal_title：Medical hypotheses

authors： Pawlikowski M,Zarzycki J

更新日期：1999-02-01 00:00:00

abstract：:Primary headaches include migraine, tension, cluster headaches, paroxysmal hemicrania and miscellaneous headaches unassociated with structural lesions. A putative role of the retino-hypothalamic-pineal (RHP) axis in the pathophysiology of primary headaches is reviewed in terms of (1) retinal dysfunction, (2) hypothala...

journal_title：Medical hypotheses

authors： Deshmukh VD

更新日期：2006-01-01 00:00:00

abstract：:Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand fo...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2001-02-01 00:00:00

abstract：:We argue that our common diseases should not necessarily be taken as a sign of physiological error. Regulatory networks developed by evolutionary forces to support reproductive fitness happen to include disease as a side-effect. For example, inflammatory and autoimmune diseases are secondary to a strong defence agains...

journal_title：Medical hypotheses

authors： Bredberg A,Lavasani S

更新日期：2013-10-01 00:00:00

abstract：:A nutraceutical that has exploded onto the prescription pad in recent years is the fat soluble vitamin, vitamin D. This is due to an increasing medical interest in the utility of the vitamin in the treatment and prevention of an array of diseases and ailments. Despite the continued debate over the correct dose, form a...

journal_title：Medical hypotheses

authors： Braithwaite MC,Kumar P,Tyagi C,Tomar LK,Choonara YE,Pillay V

更新日期：2013-10-01 00:00:00

abstract：:Although frequently disseminated to other anatomical sites, neuroblastoma (NB) is rarely reported as involving the central nervous system (CNS), which may reflect insufficient research in poorly controlled systemic disease. Here we demonstrate the involvement of the CNS in patients with NB over 18 months of age at dia...

journal_title：Medical hypotheses

authors： Odone-Filho V,Cristofani LM,Maluf PT,Almeida MTA,Halley N,Vince CSC,de Azambuja AMP,Brumatti M,Lubraico P,da Camara Lopes LHA,Leite KRM,Silva JLF,Plese JPP,Weltman E

更新日期：2020-03-01 00:00:00

abstract：:A theoretical consideration of the relationship between plasma concentrations of calcium and parathyroid hormone suggests that the reported negative correlations between these variables in normal subjects and in patients with secondary hyperparathyroidism, and the positive correlation in patients with primary hyperpar...

journal_title：Medical hypotheses

authors： Walton RJ

更新日期：1977-01-01 00:00:00