Embryonic and fetal cells which are not diseased or defective; possible sources of genes for disease prevention or treatment.


:Cancer and other diseases may be a natural biological event, the activities of which may be dependent on the constitution of the individual. Where fetal and embryonic cells are not diseased or faulty or defective, they may be useful as therapies against cancer and other diseases.


Med Hypotheses


Medical hypotheses


Caesar G





Has Abstract


2002-05-01 00:00:00














  • Down-shifting among top UK scientists? - the decline of 'revolutionary science' and the rise of 'normal science' in the UK compared with the USA.

    abstract::It is sometimes asserted that UK science is thriving, at other times that it has declined. We suggest that both assertions are partly true because the UK is thriving with respect to the volume of 'normal' science production but at the same time declining in the highest level of 'revolutionary' science. Revolutionary s...

    journal_title:Medical hypotheses

    pub_type: 社论


    authors: Charlton BG,Andras P

    更新日期:2008-01-01 00:00:00

  • Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis.

    abstract::The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The re...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Oliveira DBG

    更新日期:2018-03-01 00:00:00

  • The overlooked cause of benign prostatic hyperplasia: prostatic urethral angulation.

    abstract::Benign prostatic hyperplasia (BPH) is one of the most common problems faced by aging men and can be associated with bothersome lower urinary tract symptoms that affect quality of life by interfering with normal daily activities and sleep patterns. Despite the clinical importance of BPH, its pathogenesis is still poorl...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Cho KS,Kim J,Choi YD,Kim JH,Hong SJ

    更新日期:2008-01-01 00:00:00

  • Migraine associated with gastrointestinal disorders: A pathophysiological explanation.

    abstract:BACKGROUND:Migraine is a highly prevalent, disabling, and costly disorder worldwide. From a long time ago, headaches have been known to be associated with gastrointestinal (GI) disorders. Headaches originating from gastric complaints were appreciated by Persian Medicine (PM) scholars. Today, functional GI disorders are...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Talafi Noghani M,Namdar H

    更新日期:2019-04-01 00:00:00

  • Cancer prevention and therapy.

    abstract::Based on a consideration of biochemical mechanisms, rational methods for the prevention of cancer and for its positive regression are presented. It is demonstrated that the means employed are fundamentally opposed so that if the preventive method were to be used after the onset of cancer, it would only accelerate its ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Duchesne J

    更新日期:1981-04-01 00:00:00

  • Is the cancer process caused by deletion of one or more differentiation genes normally activated by steroid hormones?

    abstract::The hypothesis is proposed that: 1. Aflatoxin B1 and polycyclic hydrocarbon carcinogens cause the deletion of genes necessary for the production of a substance required for differentiation of the cell and activated by a steroid hormone possibly a corticosteroid. 2. Such genes could include genes for production of: glu...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Money-Kyrle AF

    更新日期:1979-09-01 00:00:00

  • Secretion of cytokines and modulation of function of immunologically competent cells.

    abstract::Cytokines and their effects are widely studied in immunology, but the cellular mechanisms responsible for producing these substances are not yet described or proven. Antigen presenting cells (APCs), macrophages and dendritic cells are suitable subjects for such a study. One of the many papers illustrating the interpla...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Fedorko ME

    更新日期:1999-08-01 00:00:00

  • Atherosclerosis regulation via media lipid-driven VSMC cholesterol efflux switch.

    abstract::It is known, that initial events in atherosclerosis arise in the intima with a parallel influx of inflammatory cells. I propose the opposite - that the disease onset begins from the media vascular smooth muscle cell (VSMC) involvement and through its utilization of modified low-density lipoproteins (LDL), and free or ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Chepelenko GV

    更新日期:2015-02-01 00:00:00

  • Endocrine factors in haematological changes seen in dogs and ferrets given oestrogens.

    abstract::High doses of oestrogens in the dog and ferret cause myeloid hyperplasia in the bone marrow superseded by hypoplasia affecting all cell lines. In the peripheral blood after an initial leucocytosis, there is thrombocytopenia, anaemia and leucopenia. These effects, which are ultimately lethal, do not occur in cats, rats...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hart JE

    更新日期:1985-02-01 00:00:00

  • Season of birth in schizophrenia: a maternal-fetal chronobiological hypothesis.

    abstract::Being born in the winter and spring significantly increases one's risk for developing schizophrenia. This birth seasonality may account for as many as 10% of all cases of schizophrenia. Maternal third trimester infections or vitamin D deficiencies are hypothesized to be the most likely cause and can account for many o...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Schwartz PJ

    更新日期:2011-06-01 00:00:00

  • Clinical indices to predict simple and mixed acid-base disturbances.

    abstract::We propose that in any acid-base disturbance there is a predictable mathematical relationship between the changes in the individual serum anionic concentrations of chloride, bicarbonate and the unmeasured anion gap. Two indices were developed, from the ratios of the changes in these anionic concentrations, that are us...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lee SM

    更新日期:1989-11-01 00:00:00

  • Etiology of neural tube defect in man--Do teratogens play any part? Evidence from sex ratios.

    abstract::Neural tube defect (NTD) is more common among spontaneously aborted fetuses than in infants born in the third trimester, but there is no direct evidence that NTD-affected conceptuses, presenting at these two different gestational ages, are components of a single disease process. Evidence for homology is here presented...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Machin GA

    更新日期:1979-02-01 00:00:00

  • Does hypoxemia prevent brain damage in birth asphyxia?

    abstract::The clinical syndrome of hypoxic ischemic encephalopathy (HIE) which occurs in association with birth asphyxia, is thought to represent a reperfusion injury consequent upon the generation of cytotoxic oxygen derived free radicals. It has recently been suggested that resuscitation of asphyxiated infants with unrestrict...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Ballot DE,Rothberg AD,Davies VA,Smith J,Kirsten G

    更新日期:1993-10-01 00:00:00

  • For ischemic brain damage, is preclinical evidence of neuroprotection by presynaptic blockade of glutamate release enough?

    abstract::Some drugs blocking glutamate release produce reduced brain injury in some animal models of cerebral ischemia whereas others lack a clear effect. Meta-analysis is a widely used technique in clinical and epidemiological studies. However, it has never been used in the analysis of preclinical studies. In order to estimat...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Nava-Ocampo AA,Reyes-Pérez H,Bello-Ramírez AM,Mansilla-Olivares A,Ponce-Monter H

    更新日期:2000-01-01 00:00:00

  • Administration of human umbilical cord blood to low birth weight infants may prevent the subsequent development of type 2 diabetes.

    abstract::Both epidemiological and experimental studies have shown that impaired growth in utero due to maternal malnutrition, resulting in low birth weight, is associated with a high incidence of glucose intolerance, insulin resistance, and type 2 diabetes in adult life. Maternal malnutrition is a worldwide problem and unavoid...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Ende N,Reddi AS

    更新日期:2006-01-01 00:00:00

  • Sudden infant death syndrome: hypothalamic failure to sense elevated blood pyrogens.

    abstract::Sudden infant death syndrome (SIDS) is frequently associated with a mild infection, the incidence peaking during the third month of life. We hypothesize that the neonatal immaturity of both the acute febrile response and hypothalamus promote neonatal protection from SIDS. Vagal afferents modify the febrile response. V...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Reid GM,Tervit H

    更新日期:1999-06-01 00:00:00

  • Hypothalamic opioid-melanocortin appetitive balance and addictive craving.

    abstract::Whilst the parallels between drug and food craving are receiving increasing attention, the recently elucidated complex physiology of the hypothalamic appetite regulatory centres has been largely overlooked in the efforts to understand drug craving which is one of the most refractory and problematic aspects of drug and...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Reece AS

    更新日期:2011-01-01 00:00:00

  • "Therapeutic" facemasks.

    abstract::There must be pathophysiological reason why "cold" viruses like SARS-CoV-2 show proclivity to nasal cavity, oral cavity, pharyngeal cavity and upper airways which have lower temperature than core body temperature. Henceforth, facemasks' "therapeutic" role against SARS-CoV-2 must be explored because personal "therapeut...

    journal_title:Medical hypotheses

    pub_type: 信件


    authors: Gupta D

    更新日期:2020-10-01 00:00:00

  • Pharmacological manipulation of ataxia-telangiectasia kinase activity as a treatment for Parkinson's disease.

    abstract::Parkinson's disease (PD) is a major cause of morbidity and mortality among older individuals. Although the causes of Parkinson's disease are multifactorial, considerable evidence indicates that elevated labile iron in the substantia nigra pars compacta plays an important role in producing oxyradicals which subsequentl...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Edwin Shackelford R,Manuszak RP,Heard SC,Link CJ,Wang S

    更新日期:2005-01-01 00:00:00

  • Treatment-induced stress syndromes.

    abstract::Placebo controlled trials in disease states as currently constituted are designed to show a drug "works" when in fact it may not. Efficacy of this type may be constructed in trials that demonstrate some marginal superiority of a drug over placebo in disease states that do not take into account any potentialities of th...

    journal_title:Medical hypotheses

    pub_type: 社论,历史文章,评审


    authors: Healy D

    更新日期:2010-05-01 00:00:00

  • Platelet hyperactivity in COVID-19: Can the tomato extract Fruitflow® be used as an antiplatelet regime?

    abstract::The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the impact of COVID-19 on neurological and haemostatic systems becomes mor...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: O'Kennedy N,Duttaroy AK

    更新日期:2021-01-04 00:00:00

  • Knowledge first, critique later: why it is a mistake for science education to encourage junior students to discuss, challenge and debate scientific knowledge.

    abstract::In UK educational circles it has long been regarded as a platitude that a good scientific education at school and undergraduate level should aim to teach critical thinking and encourage students to challenge mainstream science, debate scientific issues and express their personal opinions. However, I believe that this ...

    journal_title:Medical hypotheses

    pub_type: 社论


    authors: Charlton BG

    更新日期:2010-02-01 00:00:00

  • Is cancer a genetic program with an unknown function?

    abstract::Cancer is a tissue that requires a genetic program, possibly involving hundreds of genes, as indicated by studies of differential gene expression performed with microarrays in various types of cancer. Cancer is thus a biological process of considerable precision as described by Schrödinger's equation, and it is not si...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Garcia-Garcia A

    更新日期:2009-04-01 00:00:00

  • A hypothesis on the conflicting results of angiotensin converting enzyme inhibitor in the prevention of contrast-induced nephropathy.

    abstract::Contrast-induced nephropathy (CIN) is regarded as acute tubular necrosis resulting from the cytotoxicity of contrast media and the medullary hypoxia linking to the interplay of vasoconstriction and vasodilatation. Saline infusion may prevent CIN by inhibiting renin release and thus production of angiotensin II (ANG II...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Wong PC,Guo J,Zhang A

    更新日期:2015-12-01 00:00:00

  • Abnormal fluctuations of acetylcholine and serotonin.

    abstract::Abnormal fluctuations of acetylcholine and serotonin might cause, or be correlated with, a variety of symptoms. This communication cites evidence which suggests that fluctuations of serotonin might have a causative role in migraine, mania, and depression and that fluctuations of acetylcholine might have a causative ro...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Brown DW

    更新日期:1993-05-01 00:00:00

  • Insulin resistance: a potential marker and risk factor for active tuberculosis?

    abstract::Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control effor...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Mao F,Chen T,Zhao Y,Zhang C,Bai B,Zhao S,Xu Z,Shi C

    更新日期:2011-07-01 00:00:00

  • Is systemic hypertension only a sign of chronic sodium chloride intoxication?

    abstract::The most important obstacle for preventing hypertension is the belief that systemic hypertension has no identifiable cause. This belief, hiding the main offender, sodium chloride, causes too much time wasting for combating against hypertension. Accepting that sodium chloride is a drug and re-evaluating the situation a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Tekol Y

    更新日期:2006-01-01 00:00:00

  • Are consumers satisfied with the use of prosthetic sports feet and the provision process? A mixed-methods study.

    abstract:BACKGROUND:Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Poonsiri J,van Putten SWE,Ausma AT,Geertzen JHB,Dijkstra PU,Dekker R

    更新日期:2020-10-01 00:00:00

  • FNDC5/irisin, a molecular target for boosting reward-related learning and motivation.

    abstract::Interventions focusing on the prevention and treatment of chronic non-communicable diseases are on rise. In the current article, we propose that dysfunction of the mesocortico-limbic reward system contributes to the emergence of the WHO-identified risk behaviors (tobacco use, unhealthy diet, physical inactivity and ha...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Zsuga J,Tajti G,Papp C,Juhasz B,Gesztelyi R

    更新日期:2016-05-01 00:00:00

  • Destruction of human immunodeficiency-infected cells by ferrofluid particles manipulated by an external magnetic field: mechanical disruption and selective introduction of cytotoxic or antiretroviral substances into target cells.

    abstract::Submagnetic domain magnetic fluid particles of approximately 10 nm average diameter complexed with CD4 or monoclonal antibody and then injected into the patient, will localize to the cell membrane of the target cell. These ferrofluid particles will interact with an externally applied rotating magnetic field of rapidly...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Peasley KW

    更新日期:1996-01-01 00:00:00