Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches.

abstract：:The affected individual of hair loss demands help, because hair is viewed as a sign of youth and good health. Nowadays treatment of alopecia includes drug therapy and hair transplantation. Some drugs may promote hair growth, at least temporarily, but the treatment is effective only in milder alopecia, instead of exten...

journal_title：Medical hypotheses

authors： Zhao J,Liu LQ,Wang YJ,Yang W,Geng WX,Wei J,Li LW,Chen FL

更新日期：2008-01-01 00:00:00

abstract：:Hyperplasia of the coronoid process of the mandible has been observed in conditions like Oral submucous fibrosis, TMJ ankylosis, etc. The etiopathogenesis of this coronoid overgrowth has not been clearly sequenced or adequately hypothesized, and no definite mechanism has so far been advocated to explain this elongatio...

journal_title：Medical hypotheses

authors： Chakranarayan A,Jeyaraj P

更新日期：2011-11-01 00:00:00

abstract：:With spinal anesthesia the level of surgical analgesia is mostly reported without reference to the neuroanatomic map of spinal nerves. The classical maps are variably and inconsistently reported in many textbooks. Because of the differences between the classical maps of Keegan and Garrett and of Foerster, and also bec...

journal_title：Medical hypotheses

authors： Van Bogaert LJ

更新日期：1997-06-01 00:00:00

abstract：:This paper compares two models of the sense of smell and demonstrates that the new model has advantages over the accepted model with implications for medical research. The accepted transduction model had an odourant or pheromone contacting an aqueous sensory lymph then movement through it to a receptor membrane beneat...

journal_title：Medical hypotheses

authors： Nicholson B

更新日期：2001-09-01 00:00:00

abstract：:The major thesis of the proposed hypothesis is that in the absence of microbial material synovial macrophages in rheumatoid arthritis patients continue to release interleukin 1, which perpetuates the inflammation so characteristic of the disease. Its release is suggested to result from an altered synovial macrophage g...

journal_title：Medical hypotheses

authors： Rafter GW

更新日期：1982-10-01 00:00:00

abstract：:It has been previously proposed that conscious process involves the collapse of quantum, dynamical brain states through conscious observation. It has been further proposed that the brain process has an active role in selecting the status of uncertain stimuli. On the basis of these proposals it was predicted that event...

journal_title：Medical hypotheses

authors： Germine M

更新日期：2004-01-01 00:00:00

abstract：:Genetic diseases of the skeletal system are difficult to accurately diagnose. Changes in the chemical structure of collagen significantly modify the structure of collagen in bone. The ratio of collagen hydration to hydroxylation reflects specific features of the collagen structure. The hypothesis proposes to use this ...

journal_title：Medical hypotheses

authors： Papatheofanis FJ

更新日期：1988-11-01 00:00:00

abstract：:The human placenta contains a significant amount of histamine, a potent vasoconstrictor of the placental vasculature, shown by the author to be stored within the tissues' mast cells. The proposed hypothesis suggests that placental mast cells may have an important role in normal and, or pathological processes during pr...

journal_title：Medical hypotheses

authors： Purcell WM

更新日期：1992-11-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) is regarded as acute tubular necrosis resulting from the cytotoxicity of contrast media and the medullary hypoxia linking to the interplay of vasoconstriction and vasodilatation. Saline infusion may prevent CIN by inhibiting renin release and thus production of angiotensin II (ANG II...

journal_title：Medical hypotheses

authors： Wong PC,Guo J,Zhang A

更新日期：2015-12-01 00:00:00

abstract：:Arthritis is inflammation in a joint often with joint damage, usually accompanied by pain, swelling and stiffness, resulting from infection, trauma, degenerative changes, metabolic disturbances, autoimmune or other causes. It occurs in various forms, including rheumatoid arthritis, osteoarthritis, bacterial arthritis ...

journal_title：Medical hypotheses

authors： Eby G

更新日期：2005-01-01 00:00:00

abstract：:The morphological changes used to confirm a diagnosis of coeliac disease (CD) are precisely those predicted if the surface energy of the interface between duodenal epithelium and the luminal contents were raised to levels comparable to those demonstrated by the hydrophobic nature of the stomach wall. This hypothesis p...

journal_title：Medical hypotheses

authors： Hills BA,Godwin IR

更新日期：1990-07-01 00:00:00

abstract：:Transient period represents the time window between the exposure and response to the given stimuli inflicting the stress on the host. However, this time window is unlikely to engage in variety of signaling to culminate drastic impact on the host cell rather it is evolutionary in its sense implying a slow process. But ...

journal_title：Medical hypotheses

authors： Kannan S

更新日期：2004-01-01 00:00:00

abstract：:Mucous membrane pemphigoid (MMP) is a subtype of autoimmune subepidermal blistering diseases characterized by autoantibodies to structural components of the hemidesmosome primarily affecting mucous membranes. Inflammation-related progressive scarring can lead to serious complications, including blindness, and the dise...

journal_title：Medical hypotheses

authors： Kasperkiewicz M,Płatkowska A,Zalewska A,Zillikens D

更新日期：2015-10-01 00:00:00

abstract：:Peripheral arterial disease in the legs represents a subset of atherosclerosis that manifests a particularly sinister profile. A predominance of sympathetic activity in the periphery favors the development of neurogenic atherosclerosis. Atherosclerosis may then produce flow derangements and decreased physical activity...

journal_title：Medical hypotheses

authors： Simpson JD,Doux JD,Lee PY,Yun AJ

更新日期：2006-01-01 00:00:00

abstract：:A study of the strikingly low incidence of sudden infant death syndrome in Eastern countries revealed significant differences in infant handling thought to have an etiological bearing; therefore this writer suggested that adoption of certain Eastern methods of nursing may reduce the incidence of sudden infant death sy...

journal_title：Medical hypotheses

authors： David CM

更新日期：1997-07-01 00:00:00

abstract：:The 'Big Bang' is used to describe the origin of the Universe. While such an event could not create itself the expression is graphic. Tissue damage, traumatic, thermal, chemical; bites; insect, animal or human are all bad, but also well known factors which favor and initiate pathogenic activity. Antedating and outrank...

journal_title：Medical hypotheses

authors： Baggot MG

更新日期：1991-06-01 00:00:00

abstract：:We were interested whether fluorine, at the concentrations regarded as normal, can play a role in PCOS pathogenesis. The effect was not described in PCOS. Women with PCOS were diagnosed according to Rotterdam's criteria. The average age of 40 examined women with PCOS was 26.3 ± 5.5 years, BMI-29.16 ± 0.8, WHR-0.91 ± 0...

journal_title：Medical hypotheses

authors： Szczuko M,Splinter J,Zapałowska-Chwyć M,Ziętek M,Maciejewska D

更新日期：2019-07-01 00:00:00

abstract：:Essential hypertension is a heterogeneous multifactorial syndrome associated with a high cardiovascular risk. A multiple choice of antihypertensive drugs is available; however, a high individual variability to the antihypertensive therapy is still responsible for a modest reduction of the CV risk and not satisfactory ...

journal_title：Medical hypotheses

authors： Ferrari P,Ferrandi M,Valentini G,Manunta P,Bianchi G

更新日期：2007-01-01 00:00:00

abstract：:A comparison is made of the x-ray induced thyroid adenocarcinoma in the rat by the in-vitro, in-vivo method of Clifton et al. with previous data of Doniach on in-vivo irradiation in whole animals. The Clifton data consists of only one point at 500 rad. I have assumed that the probability of transformation per viable c...

journal_title：Medical hypotheses

authors： Rosen P

更新日期：1984-04-01 00:00:00

abstract：:It is postulated that the metabolically variable fine structure of pericellular heparan glycosaminoglycans affects the ability of these molecules to influence cell proliferation-associated proteinase-catalysed reactions occurring at cell surfaces. Evidence suggesting the possibility of a wide repertoire of glycosamino...

journal_title：Medical hypotheses

authors： Long WF,Williamson FB

更新日期：1983-07-01 00:00:00

abstract：:Neandertals were an anatomically distinct hominoid species inhabiting a vast geographical area ranging from Portugal to western Siberia and from northern Europe to the Middle East. The species became extinct 28,000 years ago, coinciding with the arrival of anatomically modern humans (AMHs) in Europe 40,000 years ago. ...

journal_title：Medical hypotheses

authors： Wolff H,Greenwood AD

更新日期：2010-07-01 00:00:00

abstract：:Lymphocytes of the CD8 phenotype play an important role in controlling viral burden in HIV-1 infection. Cytotoxic CD8+ T lymphocytes (CTL) can kill HIV-infected cells and in addition, are able to secrete a soluble factor that inhibits HIV replication. In most cases, HIV-infected individuals experience an unexplained C...

journal_title：Medical hypotheses

authors： Mercure L,Wainberg MA

更新日期：1994-03-01 00:00:00

abstract：:The concept of local pathology has long served neurology admirably. Relevant models include self-organizing nonlinear brain dynamics, global workspace and dynamic core theories. However such models are inconsistent with certain clinical phenomena found in Charles Bonnet syndrome, disjunctive agnosia and schizophrenia,...

journal_title：Medical hypotheses

authors： Globus GG,O'Carroll CP

更新日期：2010-11-01 00:00:00

abstract：:The authors hypothesize that the impairment of hypothalamic-pituitary-gonadal axis in patients suffering from anorexia nervosa depends (at least in part) on the increased sensitivity to endogenous melatonin. The hypothesis is based mainly on the following facts: (1) melatonin is well known to exert an inhibitory effec...

journal_title：Medical hypotheses

authors： Pawlikowski M,Zarzycki J

更新日期：1999-02-01 00:00:00

abstract：:TP53 (Tumor Protein 53, previously known as p53) is probably the best known of all tumor suppressor genes, and is mutated in nearly all (96%) high-grade serous ovarian cancer (HGS-OvCa), which is the most common histopathological type of epithelial ovarian cancer (EOC). Recently, TP53 is found to involve in regulating...

journal_title：Medical hypotheses

authors： Hu J,Liu Z,Wang X

更新日期：2013-10-01 00:00:00

abstract：:Restless legs syndrome (RLS) exhibits sensorimotor symptoms. In familial cases, a gene at chromosomal location 9p-24-22 is linked to RLS and the expressed mutation is Dopamine Receptor Specific Individual Sensitivity (DRSIS). The symptoms are triggered during changes in alertness, generally at sleep hours, resulting f...

journal_title：Medical hypotheses

authors： Akpinar S

更新日期：2009-08-01 00:00:00

abstract：:COVID-19 exacts a disproportionate toll on both the elderly and those with diabetes; these patients are more likely to require costly intensive care, longer hospitalisation, and die from complications. Nations would thus find it extremely difficult to either lift or sustain socially, economically, and politically dama...

journal_title：Medical hypotheses

authors： Wee AKH

更新日期：2021-01-01 00:00:00

abstract：:Exercise-induced hypoalgesia is characterised by a reduction in pain sensitivity following exercise. Recently, low intensity exercise performed with blood flow restriction has been shown to induce hypoalgesia. The purpose of this manuscript is to discuss the mechanisms of exercise-induced hypoalgesia and provide ratio...

journal_title：Medical hypotheses

authors： Hughes L,Patterson SD

更新日期：2019-11-01 00:00:00

abstract：:No survival profit has been achieved for patients with disseminated prostate cancer since hormonal therapy was introduced. It is proposed that dissemination of rare prostatic cancer stem cells may lead to metastatic disease and that resistance of these cells to androgen ablation makes them responsible for failure of c...

journal_title：Medical hypotheses

authors： Drewa T,Styczynski J

更新日期：2008-11-01 00:00:00

abstract：:Trypanosomiasis is common in Africa and South America. The surface of trypanosomes is covered by glycosyl phosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) that contains the fatty acid myristate (14:0) as its lipid moiety that is essential for its survival. Myristic acid, being a saturated fatty a...

journal_title：Medical hypotheses

authors： Das UN

更新日期：2010-04-01 00:00:00