Abstract:
:The morphological changes used to confirm a diagnosis of coeliac disease (CD) are precisely those predicted if the surface energy of the interface between duodenal epithelium and the luminal contents were raised to levels comparable to those demonstrated by the hydrophobic nature of the stomach wall. This hypothesis pursues the concept that, in coeliac patients, the gastric mucosal barrier (GMB) is effectively extended from the stomach to coat the duodenum, thus closing the window of absorption in the Gl tract. If studies are correct which indicate that the GMB is a physical reality provided by an adsorbed monolayer of surface-active phospholipid (surfactant) which renders surfaces hydrophobic, then it could also act as a barrier to the absorption of nutrients in the duodenum. Gluten, or its more active polypeptide fragment gliadin, exacerbates the situation in CD by acting as very effective carriers for the insoluble phospholipid which is deposited at the duodenal surface where they are digested by brush-border and pancreatic enzymes.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Hills BA,Godwin IRdoi
10.1016/0306-9877(90)90126-ysubject
Has Abstractpub_date
1990-07-01 00:00:00pages
219-23issue
3eissn
0306-9877issn
1532-2777pii
0306-9877(90)90126-Yjournal_volume
32pub_type
杂志文章abstract::We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...
journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.09.041
更新日期:2012-01-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.07.027
更新日期:2012-08-20 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1984-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(78)90051-8
更新日期:1978-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1308
更新日期:2001-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.06.027
更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.12.020
更新日期:2019-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.09.014
更新日期:2014-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.06.040
更新日期:2011-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.09.008
更新日期:2014-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.02.050
更新日期:2004-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(82)90116-5
更新日期:1982-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90185-0
更新日期:1989-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1298
更新日期:2001-07-01 00:00:00