Nasopharyngeal angiofibroma with intracellular accumulation of SPARC - a hypothesis (SPARC in nasopharyngeal angiofibroma).

abstract：:In endemic pemphigus foliaceus (EPF) or "fogo selvagem" the epidemiological evidence shows that all the described outbreaks occur on the banks of rivers where there is mercury contamination from alluvium gold mining and deforestation. Pathophysiological evidence shows a similarity to pemphigus induced by sulphydryl (S...

journal_title：Medical hypotheses

authors： Robledo MA

更新日期：2012-01-01 00:00:00

abstract：:For almost 70 years, essential fatty acid deficiency has been known to be associated with skin disorders, vessel abnormalities, and increased tumorigenesis. However, the underlying molecular and cellular mechanism is largely unknown. Recently, it has been reported that essential fatty acids regulate cell adhesion by m...

journal_title：Medical hypotheses

authors： Jiang WG,Eynard AR,Mansel RE

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Huachansu, a Chinese medicine that comes from dried toad venom from the skin glands of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, has been used in treatment of cancers. We conducted a meta-analysis to evaluate the efficacy and safety of Huachansu combined with chemotherapy for advanced gas...

journal_title：Medical hypotheses

authors： Xie X,Huang X,Li J,Lv X,Huang J,Tang S,Sun Y

更新日期：2013-08-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a complex and heterogeneous disease characterized by central obesity, impaired glucose metabolism, dyslipidemia, arterial hypertension, insulin resistance and high-sensitivity C-reactive protein. In 2006, a neurotrophic hypothesis of the etiopathogenesis of MetS was launched. This hypothes...

journal_title：Medical hypotheses

authors： Hristova MG

更新日期：2013-10-01 00:00:00

abstract：:Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...

journal_title：Medical hypotheses

authors： Ghasemi R,Grassadonia A,Tinari N,Piccolo E,Natoli C,Tomao F,Iacobelli S

更新日期：2013-01-01 00:00:00

abstract：:Ebola virus (EBOV) infection is associated with modulation of cytokine expression in infected patients. EBOV has been shown to interact directly with immune cells (at minimum with macrophages and dendritic cells) and modulation of cytokine expression has also been observed in vitro, which is similar to that in vivo. T...

journal_title：Medical hypotheses

authors： Denner J

更新日期：2015-09-01 00:00:00

abstract：:The hepatitis B infection leads to various profound pathological processes in liver metabolism. Some biochemical alterations detectable by blood analysis are currently used for a preliminary evaluation of the infection. Based on existing data we present here evidence that non-protein amino acid L-homoserine is a patho...

journal_title：Medical hypotheses

authors： Gazarian KG,Gening LV,Gazarian TG

更新日期：2002-04-01 00:00:00

abstract：:Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic disease in adults, and it is thought to be increasing in incidence. FSGS is often difficult to treat and even has a high propensity to relapse after transplant. Indeed, this suggests that there might be some circulating factor responsible for pro...

journal_title：Medical hypotheses

authors： Altschuler EL

更新日期：2001-12-01 00:00:00

abstract：:Pinealectomy leads to increased formation of fibrous tissue in the abdominal cavity, increased skin pigmentation and elevated cholesterol and alkaline phosphatase levels. It also leads to reduced formation and/or action of prostaglandin (PG) E1 and thromboxane (TX) A2. PGE1 plays an important role in enhancing functio...

journal_title：Medical hypotheses

authors： Cunnane SC,Manku MS,Horrobin DF

更新日期：1979-04-01 00:00:00

abstract：:For more than 35 years the author has treated multiple serious diseases in cats and dogs by correcting an unrecognized endocrine-immune imbalance originating with a deficiency or defect of cortisol. The cortisol abnormality creates a domino effect on feedback loops involving the hypothalamus-pituitary-adrenal axis. In...

journal_title：Medical hypotheses

authors： Plechner AJ

更新日期：2004-01-01 00:00:00

abstract：:Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could...

journal_title：Medical hypotheses

authors： Du J,Wang Z

更新日期：2009-11-01 00:00:00

abstract：:Learning disability, attentional disorder and childhood major depression are frequent diagnoses in children with behavioral disturbances and impaired school performance. All three disorders are associated with right cerebral hemisphere dysfunction. Anatomical disturbance of right hemisphere function results in learnin...

journal_title：Medical hypotheses

authors： Brumback RA,Staton RD

更新日期：1982-05-01 00:00:00

abstract：:Through the analysis of accumulated experimental data of cell growth, a model of unrestricted cell growth is presented here. This model is based hypothetically on the cellular commitment to senescence as in the previously presented commitment theory. Cells are divided into 3 types, namely uncommitted cells, committed ...

journal_title：Medical hypotheses

authors： Tsuboi K,Hatabu H,Lee K,Nio Y,Tobe T,Hatanaka M

更新日期：1992-08-01 00:00:00

abstract：:The accumulation of fibrin/fibrinogen and other coagulation factors in and around solid tumors and metastatic foci has been recognized for a century as an aspect of cancer pathology. On this basis, anticoagulants and fibrinolytic agents have been deployed as adjuvant anticancer therapies, but they have proved clinical...

journal_title：Medical hypotheses

authors： Lu DY,Chen XL,Ding J

更新日期：2007-01-01 00:00:00

abstract：:A bi-directional association between mood disorders and migraine has been consistently reported. Nevertheless, the neurobiological substrate underlying the association between these disorders remains unknown. In the article herein we review evidence for the role of inflammatory cytokines in the neurobiology of bipolar...

journal_title：Medical hypotheses

authors： Brietzke E,Mansur RB,Grassi-Oliveira R,Soczynska JK,McIntyre RS

更新日期：2012-05-01 00:00:00

abstract：:Over the last century and a half there has been a secular decline in the age of menarche in Western, industrialized cultures. This trend has been largely ascribed to improved nutrition and health, and we offer an alternative hypothesis that changes in socio-economic conditions have resulted in changes in the pheromona...

journal_title：Medical hypotheses

authors： Burger J,Gochfeld M

更新日期：1985-05-01 00:00:00

abstract：:Both human cell lines HL-60 and AML-193 exhibit a myeloblastic and promyelocytic morphology, respectively, but may be regarded as bipotent leukemic precursors. They can be triggered to differentiate to either granulocytes or monocytes upon retinoic acid (RA) or 1,25-dihydroxyvitamin D (D3) addition, respectively. We h...

journal_title：Medical hypotheses

authors： Camagna A,Testa U,Masciulli R,Barberi T,Samoggia P,Tritarelli E,Pustorino E,Cipollone L,Ciancio L,del Duca P,Dionisi S,del Vecchio LR,Misasi G,de Martinis C,Peschle C

更新日期：1998-03-01 00:00:00

abstract：:Data on lymphocyte biology indicate that the humoral system of B-cells is specifically active with precise analogies at all mucosal levels. Might there be a corresponding function for T-lymphocytes at the cutaneous structure level? Certain physiological findings appear to suggest that the two main lymphocyte populatio...

journal_title：Medical hypotheses

authors： Franchi F,Seminara P,Montella F

更新日期：1981-09-01 00:00:00

abstract：:Reconciling the early promising results of radiation therapy in the treatment of epilepsy with the recent theory concerning the role of nonsynaptic mechanisms in focal epileptogenesis, it is suggested that the potential of irradiation as an alternative to temporal lobe resection in intractable epilepsy should be re-ev...

journal_title：Medical hypotheses

authors： Elomaa E

更新日期：1980-05-01 00:00:00

abstract：:Breast and ovarian cancer rates in Pakistan are significantly higher than in neighboring countries. The cancer rate discrepancies cannot be explained with discrepancies of their risk factors. We propose that observed cancer excess in Pakistan is due to cancer development by negative heterosis. Heterosis occurs when a ...

journal_title：Medical hypotheses

authors： Denic S,Khatib F,Awad M,Karbani G,Milenkovic J

更新日期：2005-01-01 00:00:00

abstract：:Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the ev...

journal_title：Medical hypotheses

authors： Kalapos MP

更新日期：1999-09-01 00:00:00

abstract：:Oral submucous fibrosis (OSMF) is a potentially malignant disorder of the oral cavity. Most of the people affected by OSMF are betel quid chewers. It is characterized by epithelial atrophy and progressive accumulation of collagen fibers in lamina propria and submucosa of the oral mucosa. 7.6% of OSMF cases undergo ora...

journal_title：Medical hypotheses

authors： Sarode SC,Sarode GS

更新日期：2013-10-01 00:00:00

abstract：:In attempts to develop a rational anticancer strategy the same homologous tissue in 3 conditions were used side by side as targets: normal epidermis of the mouse back. Tween 60R-provoked benign epidermal hyperplasia, and carcinogen-provoked malignant condition. In contrast to the highest tolerated doses of the cytosta...

journal_title：Medical hypotheses

authors： Setälä K

更新日期：1982-03-01 00:00:00

abstract：:In a recent paper it was argued that all stem cells are small motile cells, the haemopoietic stem cell being no exception. Although haemopoietic stem cells arise and mature in an extravascular milieu, they are present in small numbers in the peripheral circulation, where they have a lymphocyte-like appearance, and in ...

journal_title：Medical hypotheses

authors： Drummond R

更新日期：1994-09-01 00:00:00

abstract：:To discuss the possible pathogenesis of outlet obstructive constipation (OOC) and identify the theoretical basis of the Procedure for Prolapse and Hemorrhoids (PPH) used to treat outlet obstructive constipation (OOC). 19 patients diagnosed with outlet obstructive constipation (OOC) form the case group, and 9 healthy v...

journal_title：Medical hypotheses

authors： Qin Z,Pang L,Dai W,Yan W,Zhang J,Zhao Y,Li Q,Wu K,Zhou B

更新日期：2015-07-01 00:00:00

abstract：:The origin and initiating features of PBC remain obscure despite decades of study. However, recent papers have demonstrated loss of canals of Hering (CoH) to be the earliest histologic change in liver biopsy specimens from patients with primary biliary cholangitis (PBC). We posit that CoH loss prior to significant inf...

journal_title：Medical hypotheses

authors： Theise ND,Crawford JM,Nakanuma Y,Quaglia A

更新日期：2020-03-16 00:00:00

abstract：:Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a numb...

journal_title：Medical hypotheses

authors： Truscelli G,Tanzilli G,Viceconte N,Dominici M,Arrivi A,Sommariva L,Granatelli A,Gaudio C,Mangieri E

更新日期：2017-05-01 00:00:00

abstract：:Metabolic targeting of liver 5-aminolevulinate synthase (5-ALAS) by inhibition of heme utilisation by tryptophan (Trp) 2,3-dioxygenase (TDO) or the use of tryptophan is proposed as a therapy of acute hepatic porphyrias. 5-ALAS, the rate-limiting enzyme of heme biosynthesis, is under negative feedback control by a smal...

journal_title：Medical hypotheses

authors： Badawy AA

更新日期：2019-10-01 00:00:00

abstract：:Ergothioneine is believed not to be synthesized by man but it accumulates to high concentrations in some mammalian cells as a result of dietary intake. Ergothioneine is known to chelate divalent metal ions with high affinity. Other substances which are potent chelators of divalent metal ions such as diphenylthiocarbaz...

journal_title：Medical hypotheses

authors： Epand RM

更新日期：1982-08-01 00:00:00

abstract：:Cancer stem cells are presently viewed as carriers of the growth initiating potential, repopulation capability and drug resistance in tumors. However, many of these fundamental properties of cancer are host-related, modified by cell-cell interactions and/or dependent on angiogenesis. Indeed, it is well established tha...

journal_title：Medical hypotheses

authors： Rak J

更新日期：2006-01-01 00:00:00