Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease.

abstract：:Cancer cells have a greater need for energy and a ready supply of the building blocks necessary for the synthesis of macromolecules (nucleotides, protein, lipids) in order to duplicate genome and biomass. The hypothesis can be postulated that those precursors for synthetic processes, which can only be furnished by gly...

journal_title：Medical hypotheses

authors： Dell' Antone P

更新日期：2012-09-01 00:00:00

abstract：:Exocytosis and endocytosis are the way of macromolecules transmembrane transport. Pulmonary surfactant (PS), one of such macromolecules, is secreted via exocytosis of lamellar bodies and recycled via endocytosis by type II alveolar epithelial cells (AEC II). It maintains low alveolar surface tension and is therefore e...

journal_title：Medical hypotheses

authors： Xu C,Liu W,Wang Y,Chen Z,Ji Y

更新日期：2009-02-01 00:00:00

abstract：:The incidence and prevalence of Crohn's disease (CD) among children in developed countries is extremely high. Although, dietary factors have long been implicated, to date no single causative element has been identified. Risks or benefits for CD from dietary elements would depend on their appropriate metabolism within ...

journal_title：Medical hypotheses

authors： K Amre D,G Seidman E

更新日期：2003-03-01 00:00:00

abstract：:The right timing of surgical intervention in patients with aortic insufficiency is the crucial precondition for optimal postoperative course. To meet this demand, it is essential to have precise knowledge of the pathogenesis of this disease. Within the rabbit model of aortic insufficiency, four periods of adaptational...

journal_title：Medical hypotheses

authors： Simko F

更新日期：1995-12-01 00:00:00

abstract：:Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metaboli...

journal_title：Medical hypotheses

authors： Lehmann C,Sharawy N,Zhou J,Pavlovic D

更新日期：2012-09-01 00:00:00

abstract：:Bacterial biofilms have been found in many human bacterial infectious processes including chronic rhinosinusitis. It was found also at the surface of nasal polyps, and both at the surface of the nasal part and the stalk of the antrochoanal polyp. However, our recent research clearly demonstrated the presence of the bi...

journal_title：Medical hypotheses

authors： Mladina R,Skitarelić N

更新日期：2010-10-01 00:00:00

abstract：:The possibility of a pathway, common to progression, in entities in which activated macrophages or microglia are present, amenable to particular therapies, is discussed. Immunoglobulin synthesis and activation of the complement pathway may be critical elements in progression. It is possible progression in a proportion...

journal_title：Medical hypotheses

authors： Milder DG

更新日期：2006-01-01 00:00:00

abstract：:In this work we propose a simple mathematical model for the analysis of the impact of control measures against an emerging infection, namely, the severe acute respiratory syndrome (SARS). The model provides a testable hypothesis by considering a dynamical equation for the contact parameter, which drops exponentially w...

journal_title：Medical hypotheses

authors： Massad E,Burattini MN,Lopez LF,Coutinho FA

更新日期：2005-01-01 00:00:00

abstract：:p27(Kip1) (here after referred to as p27) is a member of a family of cyclin-dependent kinase inhibitors that control cell cycle. There is a considerable evidence that p27 plays a pivotal role in multiple foundational cellular processes, including cell proliferation, cell differentiation, and apoptosis. A large number ...

journal_title：Medical hypotheses

authors： Guan X,Chen L,Wang J

更新日期：2007-01-01 00:00:00

abstract：:Auer rods are cytoplasmic inclusions found only in the leukaemic cells of some cases of acute myeloid leukaemia (AML). The ultrastructure of Auer rods is different in different sub-types of the disease and it is suggested here that this may be a consequence of the Auer rods consisting of different crystalline forms of...

journal_title：Medical hypotheses

authors： Pearson EC

更新日期：1989-11-01 00:00:00

abstract：:Bacteria initiated peri-implantitis can lead to bone destruction around a dental implant, modifying its surface and preventing re-osseointegration. Consequently, all available methods for treating periimplantitis have disappointing long-term results. Implant failure will lead to loss of the prosthetic reconstruction a...

journal_title：Medical hypotheses

authors： Chaushu L,Shabat R,Gadyukov A,Chaushu G

更新日期：2018-12-01 00:00:00

abstract：:Over the last century and a half there has been a secular decline in the age of menarche in Western, industrialized cultures. This trend has been largely ascribed to improved nutrition and health, and we offer an alternative hypothesis that changes in socio-economic conditions have resulted in changes in the pheromona...

journal_title：Medical hypotheses

authors： Burger J,Gochfeld M

更新日期：1985-05-01 00:00:00

abstract：:The results of numerous investigations on the impact of obesity on renal insufficiency conducted in recent years introduce certain dilemmas about their mutual agreement. Some studies suggest that obesity is negatively correlated with the terminal phase of renal failure. On the other hand, other research has shown that...

journal_title：Medical hypotheses

authors： Stolic R

更新日期：2010-12-01 00:00:00

abstract：:Delayed healing and nonunions of bone fracture are critical problems in orthopedic surgery. Electrical stimulation has been used as a therapeutic method for enhancing bone healing for a long time. Despite unanimous clinical success, the underlying mechanism concerning bone tissue in response to electrical stimulation ...

journal_title：Medical hypotheses

authors： Huang CP,Chen XM,Chen ZQ

更新日期：2008-01-01 00:00:00

abstract：:The high prevalence of deleterious polygenic type 2 diabetes (T2D) is a paradox requiring explanation beyond food excess, inactivity and the obesity resulting from positive energy balance. Historically, hunting-foraging and later agrarian communities often manifested a converse negative energy balance due to nutrition...

journal_title：Medical hypotheses

authors： Wise PH

更新日期：2019-06-01 00:00:00

abstract：:For some patients with radiculopathy a source of nerve root compression cannot be identified despite positive electromyography (EMG) evidence. This discrepancy hampers the effective clinical management for these individuals. Although it has been well-established that tissues in the cervical spine move in a three-dimen...

journal_title：Medical hypotheses

authors： Jaumard NV,Udupa JK,Siegler S,Schuster JM,Hilibrand AS,Hirsch BE,Borthakur A,Winkelstein BA

更新日期：2013-10-01 00:00:00

abstract：:In mathematics and physics, chaos theory deals with the behavior of certain nonlinear dynamical systems that under certain conditions exhibit a phenomenon known as chaos, which is characterised by a sensitivity to initial conditions. Mathematicians paradoxically call such states of order chaos and distinguish them fro...

journal_title：Medical hypotheses

authors： Zifan A,Gharibzadeh S

更新日期：2006-01-01 00:00:00

abstract：:Carcinoma constitution originates in the hetero-duplication mitoses (4) which divide non-maturable stem cells into two different types of daughter cells: maturable and non-maturable cancerous stem cells. Throughout the progression of such mitoses, the organoid continuity of the cancer depends only on the non-maturable...

journal_title：Medical hypotheses

authors： Hirata Y

更新日期：1999-06-01 00:00:00

abstract：:The prevailing view of lung cancer is multi-step progression of normal cells into cancer cells through gain of function oncogenes coupled with loss of tumor suppressor genes. This progression of genetic damage ultimately results in the hallmarks of cancer. This theory has strong support from studies finding genetic da...

journal_title：Medical hypotheses

authors： Haura EB

更新日期：2006-01-01 00:00:00

abstract：:Numerous studies have shown that opioids and cannabinoids share some pharmacological properties. Accordingly, similarly to opioids, tolerance and dependence develops after chronic use of cannabinoids. Nitric oxide (NO) has been shown to play important roles both in opioid- and cannabinoid-induced tolerance and depende...

journal_title：Medical hypotheses

authors： Ulugol A

更新日期：2009-08-01 00:00:00

abstract：:Anorexia nervosa was explored as the possible expression of an aberration of the processing of information which ordinarily has value in life protection or extension. Each of 6 areas was briefly reviewed, and noted to have the potential for failure to balance 2 or more factors. Anorexia nervosa may prove to be a psych...

journal_title：Medical hypotheses

authors： Spencer RP

更新日期：1990-09-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) experience co-morbid illnesses, including cardiovascular disease and retinopathy. Sevelamer hydrochloride (Renagel®); a non-calcium phosphate binder reduces coronary artery and aortic calcification as compared to calcium containing phosphate binders and additionally effects i...

journal_title：Medical hypotheses

authors： Draca N,Lazic R,Simic P,Dumic-Cule I,Luetic AT,Gabric N

更新日期：2013-04-01 00:00:00

abstract：:Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuit...

journal_title：Medical hypotheses

authors： Julu POO,Shah M,Monro JA,Puri BK

更新日期：2018-01-01 00:00:00

abstract：:Apoptosis is defined as the process of ''programmed cell death'' (PCD), during which many cells simultaneously die from within along a very orderly pattern. PCD is as intrinsic for cells as mitosis and is involved in both degenerative and developmental processes of organs and organisms. The pattern of apoptotic cell d...

journal_title：Medical hypotheses

authors： Bongaerts GP

更新日期：2008-01-01 00:00:00

abstract：:Many risk factors that promote cardiovascular disease (CVD) have been identified. These include hypertension, hypercholesterolemia, diabetes, decreased estrogen in post-menopausal women, increased homocysteine, and cigarette smoking. It has recently become clear that a mechanism common to these risk factors is oxidati...

journal_title：Medical hypotheses

authors： Castelao JE,Gago-Dominguez M

更新日期：2008-01-01 00:00:00

abstract：:Increased chemotactic activity of peripheral polymorphonuclear (PMN) cells has been described in disease states of different etiology and may represent a common pathway in the generation of an inflammatory reaction. The suppressive effect of colchicine on PMN chemotaxis may explain its effect in apparently unrelated d...

journal_title：Medical hypotheses

authors： Levy M,Ehrenfeld M,Gallily R,Eliakim M

更新日期：1981-01-01 00:00:00

abstract：:One area of relative agreement in schizophrenic research is that there is grey matter volume deficit in various cortical areas associated with this illness. One theory attempting to explain this involves an exaggerated action of the normal CNS pruning process. Various aspects of this process were discussed along with ...

journal_title：Medical hypotheses

authors： Rosenthal R

更新日期：2011-07-01 00:00:00

abstract：:A hypothetical pathogenesis for a typical case of amyotrophic lateral sclerosis (ALS) follows from opinions of Rowland and results of neuroscientists at Baylor. ALS might typically result from an autoimmune disorder that causes IgG to enhance release of acetylcholine (ACh) from axon terminals. Motor neuron overactivit...

journal_title：Medical hypotheses

authors： Brown DW

更新日期：1994-06-01 00:00:00

abstract：:Many embryonic genes may be sets of repeated genes. Processes of differentiation where the quantity of gene activity changes during embryogenesis may not reflect the transcription rate per se but instead be a result of the state of expression of constitutive repeated genes. Such repeated genes (in fact or theory) is d...

journal_title：Medical hypotheses

authors： Hancock RL

更新日期：1991-03-01 00:00:00

abstract：:COVID-19 exacts a disproportionate toll on both the elderly and those with diabetes; these patients are more likely to require costly intensive care, longer hospitalisation, and die from complications. Nations would thus find it extremely difficult to either lift or sustain socially, economically, and politically dama...

journal_title：Medical hypotheses

authors： Wee AKH

更新日期：2021-01-01 00:00:00