Glutathione sodium salt as a novel adjunctive treatment for acute myocardial infarction.


:Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a number of different mechanisms. Based on experimental and clinical studies, interventions to treat reperfusion injury by antioxidants were considered to be an appropriate therapeutic option. We emphasize the hypothesis that glutathione sodium salt, a physiologic antioxidant, may be of value when administered to STEMI patients both at an early stage of myocardial reperfusion by primary angioplasty and for up to three days after the procedure, in addition to standard treatment.


Med Hypotheses


Medical hypotheses


Truscelli G,Tanzilli G,Viceconte N,Dominici M,Arrivi A,Sommariva L,Granatelli A,Gaudio C,Mangieri E




Has Abstract


2017-05-01 00:00:00












  • M. paratuberculosis and Parkinson's disease--is this a trigger.

    abstract::Genetic linkage studies and genome wide analysis have provided insights into complex medical diseases. Mycobacterium avium ss. paratuberculosis (MAP) causes Johne's disease, an important enteric inflammatory disease mostly studied in ruminant animals. MAP is also the putative cause of Crohn's disease. Moreover, MAP ha...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Dow CT

    更新日期:2014-12-01 00:00:00

  • Three-dimensional kinematic stress magnetic resonance image analysis shows promise for detecting altered anatomical relationships of tissues in the cervical spine associated with painful radiculopathy.

    abstract::For some patients with radiculopathy a source of nerve root compression cannot be identified despite positive electromyography (EMG) evidence. This discrepancy hampers the effective clinical management for these individuals. Although it has been well-established that tissues in the cervical spine move in a three-dimen...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Jaumard NV,Udupa JK,Siegler S,Schuster JM,Hilibrand AS,Hirsch BE,Borthakur A,Winkelstein BA

    更新日期:2013-10-01 00:00:00

  • Hv1 proton channel possibly promotes atherosclerosis by regulating reactive oxygen species production.

    abstract::Atherosclerosis and its fatal complications, such as myocardial infarction or stroke, represent the most common cause of morbidity or mortality in modern world. It was observed that an excess of reactive oxygen species (ROS) accompanies atherosclerosis. Under physiological circumstances, intracellular H+ accumulates a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Zheng Z,Zhang Z,Wang M

    更新日期:2020-08-01 00:00:00

  • Pellagra: A clue as to why energy failure causes diseases?

    abstract::Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Williams AC,Ramsden DB

    更新日期:2007-01-01 00:00:00

  • An intangible energy in the functioning biosystem. I: A search for its fate and a proposed method of delivery.

    abstract::This paper treats evidence for an increasing recognition of a force with intangible properties in biosystems with special reference to its ability to transport electrons at near 0 degree Kelvin. It is implied that such force, whose demonstration at these temperatures is an experimental contrivance to emphasise its str...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Reid BL

    更新日期:1995-06-01 00:00:00

  • Myosin regulatory light chain as a critical substrate of cell death: a hypothesis.

    abstract::As known, gamma-interferon-induced cell death in HeLa cells can be mediated via the recently identified protein kinase, death associated protein (DAP) kinase which is localized to the microfilament system of the cytoskeleton. However, the downstream or upstream effectors of DAP kinase remain uncertain. In the present ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Gerashchenko BI,Murata-Hori M,Hosoya H

    更新日期:2000-05-01 00:00:00

  • Balancing and imbalancing effects of astrocytic receptors in tripartite synapses. Common pathophysiological model of mental disorders and epilepsy.

    abstract::Based on a logic of balance mechanisms influencing information processing in tripartite synapses are proposed. It is hypothesized that the number of expressed astrocytic receptors determines balanced and imbalanced synaptic states. Synaptic information processing in mental disorders is underbalanced in depression, ove...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Mitterauer BJ

    更新日期:2015-04-01 00:00:00

  • Severe blood loss during spinal reconstructive procedures: the potential usefulness of topical hemostatic agents.

    abstract::Complex spinal reconstructive procedures are invariably associated with excessive intraoperative blood loss that significantly increases the risk of severe perioperative complications. In some cases, excessive hemorrhage is equivalent to estimated total blood volume. Unfortunately, widely exposed bony surfaces are not...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Block JE

    更新日期:2005-01-01 00:00:00

  • Serum hormonal concentrations following transcendental meditation--potential role of gamma aminobutyric acid.

    abstract::Transcendental mediation (TM) is a stylized form of physical and mental relaxation which is associated with changes in the secretion and release of several pituitary hormones. The hormonal changes induced by TM mimic the effects of the inhibitory neurotransmitter gamma aminobutyric acid (GABA). It is hypothesized that...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Elias AN,Wilson AF

    更新日期:1995-04-01 00:00:00

  • Cell therapy assisted autotransplantation of olfactory tract into the optic nerve: A potential treatment for optic neuropathy.

    abstract::Optic neuropathy is an invaliding pathology with diverse clinical manifestation and varying causes. Current understanding of etiopathological aspects of optical neuropathy does not provide an effective treatment protocol. In this article we discuss existing treatment methods, and their effectiveness, evaluated dependi...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Shkarubo AN,Nikolenko VN,Velichko AY,Sinelnikov MY

    更新日期:2020-10-01 00:00:00

  • Parasitic brain infection, endocannabinoids, and schizophrenia.

    abstract::Cannabis use has often been associated with various forms of psychosis. Today it is well established that everyone produces marijuana-like compounds known as endocannabinoids. The endocannabinoid system is a homeostatic regulator of all body systems including the nervous system. As a result, imbalances in the endocann...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Melamede R

    更新日期:2009-02-01 00:00:00

  • Stable genes.

    abstract::Some genes such as those for histones and RNAs are conserved unchanged through much of evolution and have numerous tandem repeat copies in the genome. It is proposed that as yet undetected 'polystrand' enzymes use such multiple copies as a means of conserving their sequence by comparing the copies and eliminating erro...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Frei JV

    更新日期:1990-08-01 00:00:00

  • Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXIV. Repeated embryonic genes in liver.

    abstract::Many embryonic genes may be sets of repeated genes. Processes of differentiation where the quantity of gene activity changes during embryogenesis may not reflect the transcription rate per se but instead be a result of the state of expression of constitutive repeated genes. Such repeated genes (in fact or theory) is d...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hancock RL

    更新日期:1991-03-01 00:00:00

  • Speculations on the initiation of chromosome replication in Escherichia coli: the dualism hypothesis.

    abstract::The exact nature of the mechanism that triggers initiation of chromosome replication in the best understood of all organisms, Escherichia coli, remains mysterious. Here, I suggest that this mechanism evolved in response to the problems that arise if chromosome replication does not occur. E. coli is now known to be hig...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Norris V

    更新日期:2011-05-01 00:00:00

  • Alpha helix capping and the conformation of threonine.

    abstract::The amino acid threonine contains two chiral carbons and thus can exist in four possible conformations. However, only a single conformation (2S, 3R) of threonine is incorporated in proteins by the cellular translation material. The conformation at the alpha carbon (carbon 2) is the same as that of the other amino acid...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Altschuler EL

    更新日期:2001-04-01 00:00:00

  • Neuronal-immune interactions in mediating stress effects in the etiology and course of schizophrenia: role of the amygdala in developmental co-ordination.

    abstract::Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Anderson G

    更新日期:2011-01-01 00:00:00

  • Edaravone: a new therapeutic approach for the treatment of acute stroke.

    abstract::Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kikuchi K,Kawahara K,Miyagi N,Uchikado H,Kuramoto T,Morimoto Y,Tancharoen S,Miura N,Takenouchi K,Oyama Y,Shrestha B,Matsuda F,Yoshida Y,Arimura S,Mera K,Tada K,Yoshinaga N,Maenosono R,Ohno Y,Hashiguchi T,Maruyama

    更新日期:2010-12-01 00:00:00

  • Neutrophil/lymphocyte ratio: Can a non-specific marker of inflammation helps to confirm the inflammatory hypothesis of the serious mental diseases? A case-control study.

    abstract:BACKGROUND:The hypotheses of autoimmune, allergic or infectious etiology of severe mental illness have been reported in the scientific literature repeatedly. The main objective of this work is to study the relationship of inflammatory, autoimmunity or recent infection markers with the fact of suffering Severe Mental Di...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Olcina Rodríguez JF,Díaz Fernández J,Orta Mira N,López-Briz E,Gómez-Pajares F

    更新日期:2019-09-01 00:00:00

  • The role of psychosocial factors in the progression of hepatocellular carcinoma.

    abstract::The number of deaths per year from hepatocellular carcinoma (HCC) exceeds 250000, placing it sixth as the cause of death from cancer worldwide. The primary etiology of most cases of HCC in the US is hepatitis B and/or C. Extensive research has demonstrated that the relationship between hepatitis B infection and the pr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Steel J,Carney M,Carr BI,Baum A

    更新日期:2004-01-01 00:00:00

  • Potential beneficial role of sevelamer hydrochloride in diabetic retinopathy.

    abstract::Patients with chronic kidney disease (CKD) experience co-morbid illnesses, including cardiovascular disease and retinopathy. Sevelamer hydrochloride (Renagel®); a non-calcium phosphate binder reduces coronary artery and aortic calcification as compared to calcium containing phosphate binders and additionally effects i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Draca N,Lazic R,Simic P,Dumic-Cule I,Luetic AT,Gabric N

    更新日期:2013-04-01 00:00:00

  • Vitamin C and cancer: examination of the Vale of Leven trial results using broad inductive reasoning.

    abstract::Cameron and Pauling have reported large survival increases in terminal cancer patients treated with Vitamin C. Their trials, which have been criticised because not based on random, double-blind principles, are reviewed here using a broad inductive method that relies on diverse data of varying quality. Conclusions are ...

    journal_title:Medical hypotheses

    pub_type: 临床试验,杂志文章


    authors: Jaffey M

    更新日期:1982-01-01 00:00:00

  • Acupuncture-brain interactions as hypothesized by mood scale recordings.

    abstract::Mood expressions encompassing positive scales like "activity, elation, contemplation, calmness" and negative scales like "anger, excitement, depression, fatigue" were applied for introducing a new tool to assess the effects of acupuncture on brain structures. Traditional acupuncture points defined in the literature fo...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Acker H,Schmidt-Rathjens C,Acker T,Fandrey J,Ehleben W

    更新日期:2015-09-01 00:00:00

  • An hypothesis concerning optimal therapy in HIV disease.

    abstract::Ampligen, a mismatched double stranded RNA, is hypothesized to be an ideal base therapy for HIV disease to which other agents, such as the nucleoside analogue, AZT, can be advantageously added. The unique properties of Ampligen which support this hypothesis include activation of immune cells, inhibition of virus repli...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Gillespie D,Carter WA

    更新日期:1992-01-01 00:00:00

  • Induction of malnutrition in chronic alcoholism: role of gastric emptying.

    abstract::Epidemiological studies reveal that chronic alcoholics exhibiting liver disease are generally malnourished. Experimental studies unequivocally demonstrate that incidence of malnutrition cannot be avoided in animals fed liquid diets containing high concentrations of alcohol. Furthermore, ingestion of additional amounts...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sankaran H,Larkin EC,Rao GA

    更新日期:1994-02-01 00:00:00

  • Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.

    abstract::Essential hypertension is a heterogeneous multifactorial syndrome associated with a high cardiovascular risk. A multiple choice of antihypertensive drugs is available; however, a high individual variability to the antihypertensive therapy is still responsible for a modest reduction of the CV risk and not satisfactory ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Ferrari P,Ferrandi M,Valentini G,Manunta P,Bianchi G

    更新日期:2007-01-01 00:00:00

  • Intrinsic toxicity of glucose, due to non-enzymatic glycation, is controlled in-vivo by deglycation systems including: FN3K-mediated deglycation of fructosamines and transglycation of aldosamines.

    abstract::Along with oxygen, glucose is an essential macronutrient for most cells, a source of carbons for biosynthesis and energy. However, alongside this indispensable role for cell survival and growth, glucose is intrinsically toxic by reacting with primary amines such as lysine in proteins in a non-enzymatic glycation proce...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Szwergold BS

    更新日期:2005-01-01 00:00:00

  • Positional nystagmus in middle ear cholesteatoma with labyrinthine fistula.

    abstract::Chronic otitis media with cholesteatoma can cause erosion of the dense labyrinthine bone overlying the inner ear organs, and this labyrinthine fistula allows pressure or mass-induced motion of the underlying perilymphatic and endolymphatic compartment, evoking vestibular symptoms. While the mechanism of a positive fis...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Jeong H,Lee DH,Shin JE,Kim CH

    更新日期:2020-11-01 00:00:00

  • Has enhanced folate status during pregnancy altered natural selection and possibly Autism prevalence? A closer look at a possible link.

    abstract::The inverse association between maternal folate status and incidence of infants born with neural tube defects (NTD's) was recognized over twenty years ago and led the US health agencies in the early 1990s to recommend that women of childbearing age consume 400 microg of folic acid each day. The FDA followed by mandati...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Rogers EJ

    更新日期:2008-09-01 00:00:00

  • Neuritic plaques in Alzheimer disease originate from neurofibrillary tangles.

    abstract::Amyloid beta-protein is a major focus in efforts to understand the etiology of Alzheimer disease yet there is little known about the mechanism of its deposition in plaques. I propose deposition of amyloid in neuritic plaques depends on the remains of neurofibrillary tangles after neuronal death. The interaction of the...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Perry G

    更新日期:1993-04-01 00:00:00

  • Degassed liquids to prevent/treat decompression sickness.

    abstract::Recompression and oxygen breathing constitute the primary treatments for decompression sickness (DCS). Increasing the volume of distribution of dissolved gas with high-volume liquid therapy represents an alternative strategy to prevent or treat DCS. Furthermore, degassing of ingested and infused liquids would increase...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Watenpaugh DE

    更新日期:2003-05-01 00:00:00