Abstract:
:Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a number of different mechanisms. Based on experimental and clinical studies, interventions to treat reperfusion injury by antioxidants were considered to be an appropriate therapeutic option. We emphasize the hypothesis that glutathione sodium salt, a physiologic antioxidant, may be of value when administered to STEMI patients both at an early stage of myocardial reperfusion by primary angioplasty and for up to three days after the procedure, in addition to standard treatment.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Truscelli G,Tanzilli G,Viceconte N,Dominici M,Arrivi A,Sommariva L,Granatelli A,Gaudio C,Mangieri Edoi
10.1016/j.mehy.2017.03.010subject
Has Abstractpub_date
2017-05-01 00:00:00pages
48-50eissn
0306-9877issn
1532-2777pii
S0306-9877(16)30583-7journal_volume
102pub_type
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