Abstract：
:Ontogenesis might be considered as the development of phylogenetically consequent genic systems that mainly imply: homoeotic genes and ras protooncogene in segmentation; ras and myc protooncogenes in gastrulation; ras, myc and other nuclear protooncogenes in organogenesis; ras myc, other nuclear and cytomembrane protooncogenes in growth-differentiation. Oncogenesis is considered as the stable regression of a transformed cell into a "para-embryonal" gene-phenotypical condition, and it is usually presented as a three-phased process: mutational events on nuclear protooncogenes-myc in particular-would determine "initiation"; other mutations on cytomembrane protooncogenes-ras, especially-would determine "promotion"; other events would finally prevent the cell from carrying out its genic programme completely, thus maintaining the reiterated expression of primitive genic systems (gastrulation and organogenesis), the embryonal products of which-malignant in an adult organism-would determine tumoral "progression".
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Manzo Gdoi
10.1016/0306-9877(89)90033-9subject
Has Abstractpub_date
1989-12-01 00:00:00pages
245-57issue
4eissn
0306-9877issn
1532-2777pii
0306-9877(89)90033-9journal_volume
30pub_type
杂志文章abstract：:A comparison of more important physical, chemical and biological properties of the nitric oxide (NO) and free stable nitroxyl radicals (nitroxides) on the base of their structural similarity is made in the article. The active moiety in the nitroxide molecule represents a sterically hindered nitric oxide. The mechanism...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1284
更新日期：2001-09-01 00:00:00
abstract：:Cardiac chambers have afferent connections to the brainstem and to the spinal cord. Vagal afferents mediate depressor responses and become activated by volume expansion, increased myocardial contractility and atrial natriuretic factor. Sympathetic afferents, on the contrary, are activated by metabolic mediators, myoca...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0029
更新日期：2000-02-01 00:00:00
abstract：:High level contamination by natural and industrial sources of the alkali earth metal, barium (Ba) has been identified in the ecosystems/workplaces that are associated with high incidence clustering of multiple sclerosis (MS) and other neurodegenerative diseases such as the transmissible spongiform encephalopathies (TS...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.034
更新日期：2004-01-01 00:00:00
abstract：:Although frequently disseminated to other anatomical sites, neuroblastoma (NB) is rarely reported as involving the central nervous system (CNS), which may reflect insufficient research in poorly controlled systemic disease. Here we demonstrate the involvement of the CNS in patients with NB over 18 months of age at dia...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109479
更新日期：2020-03-01 00:00:00
abstract：:Growing evidences suggest a link between normal tension glaucoma (NTG) and Alzheimer's disease (AD). Both of them are progressive neurodegenerative disorders. Recently researches provide a clue that optineurin may be a new common underlying risk factor involved in NTG and AD. OPTINEURIN (OPTN) gene coding for "optineu...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.06.040
更新日期：2011-10-01 00:00:00
abstract：:This hypothesized reflex relates the vertical direction of gaze to the amount of tension exerted by the ciliary muscle. Based on simple observations the following is assumed. When looking downwards a tendency for closer focusing (near searching) exists even without a specific visual stimulus, whereas looking up favors...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90016-r
更新日期：1991-12-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.12.006
更新日期：2017-02-01 00:00:00
abstract：:Scrub typhus is a mite borne infectious disease which has re-emerged in India in the 3rd millennium after years of quiescence. In this review, the authors hypothesize the various factors responsible for resurgence of this disease. The main drivers that could have contributed to the upsurge in scrub typhus cases in pas...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2018.03.019
更新日期：2018-06-01 00:00:00
abstract：:Chemo- and radio-resistant cancer cells within solid tumors undermine the effectiveness of these approaches to achieving oncolysis. These resistant cells and clusters of cells typically thrive at low oxygen tensions and are reliant on anaerobic metabolic pathways that churn out lactate. This hypoxic state is one that ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.09.013
更新日期：2007-01-01 00:00:00
abstract：:Neuronal degeneration in the post-menopausal term leads to cognitive symptoms such as anxiety, difficulty in concentrating, overreacting to minor upsets, quickly becoming irritated and forgetfulness in approximately 70-80% of all women around the world. These symptoms, which result from microtubule damage in the axon ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.06.013
更新日期：2013-09-01 00:00:00
abstract：:The paper discusses a mechanism for reciprocal translocation of midsegments between two chromatids so that one of the segments is restacked in inverted configuration. Regarding malignant cells, such process could derive from anachronistic assembly of the nuclear envelope. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90277-8
更新日期：1998-06-01 00:00:00
abstract：:The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousn...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.02.013
更新日期：2017-04-01 00:00:00
abstract：:A novel virus named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) causes symptoms that are classified as coronavirus disease (COVID-19). Respiratory conditions are extensively described among more serious cases of COVID-19, and the onset of acute respiratory distress syndrome (ARDS) is one of the hallmark features of ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109760
更新日期：2020-07-01 00:00:00
abstract：:Exercise is a key component for prevention and treatment of type 2 diabetes. However, diabetes complications affect exercise habits. Computerized clinical decision support systems (CCDSSs) may help specialists improve their decision-making abilities in the management of diseases. We hypothesized that patients' diabeti...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110070
更新日期：2020-10-01 00:00:00
abstract：:Guinea-pigs sensitised to ovalbumen excrete the antigen in their urine in a therapeutic concentration which prevents anaphylactic death after injection of a challenge dose of the ovalbumen. Sublingual administration of the correct dose of urine from allergic patients also provides therapeutic control of their allergic...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(83)90076-2
更新日期：1983-10-01 00:00:00
abstract：:It is proposed here that the initial events in gastric carcinogenesis occur at the junction of the oxyntic and antral mucosae. Intestinal metaplasia represents an adaptive counter-response to early neoplastic change at this site. Chronic gastric ulceration may arise due to the elimination of overtly dedifferentiated c...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90229-r
更新日期：1991-07-01 00:00:00
abstract：:Cardiomyopathies are the group of diseases affecting the cardiac muscle. Although they have never been related to oxidative stress diseases, an analysis of the causes of these pathologies reveals the presence of a pro-oxidative agent or that the intracardiocytic balance between oxidation and antioxidation has been bro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90453-3
更新日期：1996-08-01 00:00:00
abstract：:A birth involving shoulder dystocia can rapidly deteriorate-from a fetus with a reassuring tracing in the minutes before birth, to a neonate needing aggressive resuscitation. Infants experiencing a traumatic birth involving shoulder dystocia may be severely compromised, even when the preceding labor was uncomplicated....
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.11.019
更新日期：2009-04-01 00:00:00
abstract：:The largely empirical dopamine theory has limited value in clarifying the pathogenesis of schizophrenia, due to its inability to explain consistent imaging findings, such as cortical grey matter loss, reduced frontal and thalamic activity, and, reduced D1 receptor load. Furthermore, the most effective drug for treatin...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.06.022
更新日期：2005-01-01 00:00:00
abstract：:Interleukin (IL)-1, an established mediator of inflammation, is also a mediator of ovulation (a cyclic inflammatory-like process). We have shown that IL-1 beta induces the in vitro expression of genes believed to play important role in ovulation (IL-1 beta itself, its receptors, IL-1 beta receptor antagonist, glucose ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1389
更新日期：2002-01-01 00:00:00
abstract：:Multiple sclerosis remains a rare neurological disease of unknown aetiology, with a unique distribution, both geographically and historically. Rare in equatorial regions, it becomes increasingly common in higher latitudes; historically, it was first clinically recognized in the early nineteenth century. A hypothesis, ...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/s0306-9877(97)90065-7
更新日期：1997-12-01 00:00:00
abstract：:Encouraging results have been obtained with stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). However, local control rates decrease in larger volume disease. Several studies have found a correlation between T stage or tumor volume and local progression-free survival. In man...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.01.001
更新日期：2012-04-01 00:00:00
abstract：:A comparison is made of the x-ray induced thyroid adenocarcinoma in the rat by the in-vitro, in-vivo method of Clifton et al. with previous data of Doniach on in-vivo irradiation in whole animals. The Clifton data consists of only one point at 500 rad. I have assumed that the probability of transformation per viable c...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90070-7
更新日期：1984-04-01 00:00:00
abstract：:Salt is a major mineral element that plays fundamental roles in health and disease. Excessive salt intake is a major cause of hypertension, cardiovascular disease and stroke. Miscarriage and preeclampsia are the most common pregnancy complications with multiple etiological factors, including inflammatory and autoimmun...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.02.003
更新日期：2016-04-01 00:00:00
abstract：:The psychological attributes of intelligence and personality are usually seen as being quite distinct in nature: higher intelligence being regarded a 'gift' (bestowed mostly by heredity); while personality or 'character' is morally evaluated by others, on the assumption that it is mostly a consequence of choice? So a ...
journal_title：Medical hypotheses
pub_type： 社论
doi：10.1016/j.mehy.2009.06.048
更新日期：2009-10-01 00:00:00
abstract：:There are differences in male and female height throughout the growth period. Utilising reference standard height charts we calculated the difference in male and female height as a function of age. A triphasic relationship was observed with statistically significant peaks (males greater than females) at 8 months and 1...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(87)90122-8
更新日期：1984-07-01 00:00:00
abstract：:The author reviews the criticism aimed at medical education and suggests that its shortcomings could be corrected by modifying the curriculum so that irrelevant material is eliminated and replaced in part with the humanities. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(80)90104-8
更新日期：1980-05-01 00:00:00
abstract：:Many clinical trials have clearly demonstrated the benefit of statins in the prevention of coronary heart disease. Although other effects have subsequently been described, the so-called pleiotropic effects of statins, there is a tendency to relate all those effects, more or less directly, to inhibition of 3-hydroxy-3-...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.02.046
更新日期：2006-01-01 00:00:00
abstract：:The malignant cell, in vivo, metabolizes and respires anaerobically. For a good many years scientists have been aware of anaerobia being present in malignant growths. The prevailing opinion is that the malignant cell is able to remain viable in an anaerobic medium. This assumption is incorrect and is actually misleadi...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90057-j
更新日期：1992-12-01 00:00:00
abstract：:The exact contribution of the sirtuin family of NAD+-dependent histone deacetylases to longevity in metazoans is, at present, not completely understood but nonetheless regarded as significant. Despite the rapidly accreting evidence solidifying the role of NAD+-dependent histone deacetylase activity in longevity-promot...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.08.032
更新日期：2006-01-01 00:00:00
