The role of reactive oxygen species, antioxidants and phytopharmaceuticals in human immunodeficiency virus activity.

abstract：:Whether retroviral integration is a phenomenon specific to properties of the surrounding genomic region is a widely debated question. In this paper we attempt to enlight the involvement of genomic regions prone to DNA double strand breaks in such process, as well as the more general concept of genome plasticity concer...

journal_title：Medical hypotheses

authors： Guinet E,Mimaud V,Rossignol P,Hameau L,Benboudjema L,Jasmin C,Tovey MG,Bélec L,Lang MC

更新日期：2003-02-01 00:00:00

abstract：:The hypothesis is proposed that: 1. Aflatoxin B1 and polycyclic hydrocarbon carcinogens cause the deletion of genes necessary for the production of a substance required for differentiation of the cell and activated by a steroid hormone possibly a corticosteroid. 2. Such genes could include genes for production of: glu...

journal_title：Medical hypotheses

authors： Money-Kyrle AF

更新日期：1979-09-01 00:00:00

abstract：:A hypothesis which explains disease prevalence among different socio-economic groups following early infantile modulation of cell-mediated immunity by infection and nutrition related stress is presented. Wealthy populations living under highly hygienic circumstances can develop their cell-mediated immunity to genetic ...

journal_title：Medical hypotheses

authors： Dutz W

更新日期：1975-11-01 00:00:00

abstract：:Exosomes are small vesicles that are released by almost every cell type and play a crucial role in many physiological and pathological processes associated with different diseases. Specifically, they promote angiogenesis in the pathogenesis of some diseases. According to previous research, the proteins of exosomes tak...

journal_title：Medical hypotheses

authors： Tong Y,Zhou YL,Wang YX,Zhao PQ,Wang ZY

更新日期：2016-12-01 00:00:00

abstract：:Spinocerebellar ataxia type 2 (SCA2) is caused by a CAG trinucleotide repeat expansion within the coding region of the ataxin-2 gene. Affected individuals typically have between 34 and 57 CAG repeats. Signs of the disorder generally begin in adulthood and include progressive ataxia, dysarthria, tremor, hyporeflexia, a...

journal_title：Medical hypotheses

authors： Bauer PO,Zumrova A,Matoska V,Mitsui K,Goetz P

更新日期：2004-01-01 00:00:00

abstract：:Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis pre...

journal_title：Medical hypotheses

authors： Singh V

更新日期：2016-10-01 00:00:00

abstract：:Daily disturbances of the earth's magnetic field produce variations in geomagnetic activity (GMA) that are reportedly associated with widespread effects on human health and behaviour. Some of these effects could be mediated by an established influence of GMA on the secretion of melatonin. There is evidence from unrela...

journal_title：Medical hypotheses

authors： Lipnicki DM

更新日期：2009-07-01 00:00:00

abstract：:Through the analysis of accumulated experimental data of cell growth, a model of unrestricted cell growth is presented here. This model is based hypothetically on the cellular commitment to senescence as in the previously presented commitment theory. Cells are divided into 3 types, namely uncommitted cells, committed ...

journal_title：Medical hypotheses

authors： Tsuboi K,Hatabu H,Lee K,Nio Y,Tobe T,Hatanaka M

更新日期：1992-08-01 00:00:00

abstract：:Thrombotic thrombocytopenic purpura (TTP) is a severe, occlusive, thrombotic microangiopathy characterized by a systemic platelet aggregation, organ ischemia, profound thrombocytopenia and erythrocyte fragmentation. Recent observations have documented that a deficiency of a von Willebrand factor (VWF)-cleaving proteas...

journal_title：Medical hypotheses

authors： Franchini M

更新日期：2005-01-01 00:00:00

abstract：:Inflammation integrates diverse mechanisms that are associated not only with pathological conditions, such as cardiovascular diseases, type 2 diabetes, obesity, neurodegenerative diseases and cancer, but also with physiological processes like reproduction i.e. oogenesis and embryogenesis as well as aging. In the curre...

journal_title：Medical hypotheses

authors： Aller MA,Arias N,Fuentes-Julian S,Blazquez-Martinez A,Argudo S,Miguel MP,Arias JL,Arias J

更新日期：2012-06-01 00:00:00

abstract：:For almost 70 years, essential fatty acid deficiency has been known to be associated with skin disorders, vessel abnormalities, and increased tumorigenesis. However, the underlying molecular and cellular mechanism is largely unknown. Recently, it has been reported that essential fatty acids regulate cell adhesion by m...

journal_title：Medical hypotheses

authors： Jiang WG,Eynard AR,Mansel RE

更新日期：2000-09-01 00:00:00

abstract：:We describe a six-month-old girl with microcephaly, developmental delay, truncal hypotonia, left pyramidal signs, partial seizures and myoclonic spasms, born to a feverish mother. MRI showed bilateral vascular lesions in the territory of the middle cerebral arteries, prevalent in the right hemisphere, together with hy...

journal_title：Medical hypotheses

authors： Spalice A,Del Balzo F,Papetti L,Nicita F,Ursitti F,Salvatori G,Iannetti P

更新日期：2011-08-01 00:00:00

abstract：:Prostate cancer incidence increases with age; along with many other cancers, it could be considered a disease of aging. Prostate cancer screening has led to a significant proportion of men diagnosed with low-grade, low-stage prostate cancer who are now more likely to choose an active surveillance strategy rather than ...

journal_title：Medical hypotheses

authors： Liss MA,Rickborn L,DiGiovanni J,Bacich D,DeGraffenried LA,Parihar M,Thompson IM,Sharp ZD

更新日期：2018-08-01 00:00:00

abstract：:Temporomandibular joint (TMJ) ankylosis is a disease that severely affects the human health. Although it is well known that trauma is the most common cause of TMJ ankylosis, the mechanisms by which the traumatic TMJ ankylosis develops are unclear. The existing hypothesis is not convincing in explaining the genesis of ...

journal_title：Medical hypotheses

authors： Meng FW,Zhao JL,Hu KJ,Liu YP

更新日期：2009-07-01 00:00:00

abstract：:The etiology of sudden-death ischemic heart disease (SDIHD) remains an enigma. Data will be presented which suggest that SDIHD may be due to hypomagnesemia in and around the coronary arterial and arteriolar vessels. We have found that blood vessels (especially arteries and arterioles) deficient with respect to Mg can ...

journal_title：Medical hypotheses

authors： Altura BM

更新日期：1979-08-01 00:00:00

abstract：:Despite aggressive intervention, patients who survive an out-of-hospital cardiac arrest (OHCA) generally have very poor prognoses, with nationwide survival rates of approximately 10-20%. Approximately 90% of survivors will have moderate to severe neurological injury ranging from moderate cognitive impairment to brain ...

journal_title：Medical hypotheses

authors： Gul SS,Huesgen KW,Wang KK,Mark K,Tyndall JA

更新日期：2017-08-01 00:00:00

abstract：:For some patients with radiculopathy a source of nerve root compression cannot be identified despite positive electromyography (EMG) evidence. This discrepancy hampers the effective clinical management for these individuals. Although it has been well-established that tissues in the cervical spine move in a three-dimen...

journal_title：Medical hypotheses

authors： Jaumard NV,Udupa JK,Siegler S,Schuster JM,Hilibrand AS,Hirsch BE,Borthakur A,Winkelstein BA

更新日期：2013-10-01 00:00:00

abstract：:Evidence exists for the presence of a neuro-anatomy that can produce cardiac vasospasm. Recent experimental and clinical data suggest that this neuro-anatomic mechanism can be activated by behavioral events in the psycho-social surround of the patient with coronary artery disease. I hypothesize that this mechanism can...

journal_title：Medical hypotheses

authors： Natelson BH

更新日期：1987-12-01 00:00:00

abstract：:The mechanism by which polyglutamine expansions in several proteins lead to neurodegenerative disorders remains largely unknown. The biochemical properties of polyglutamine repeats suggest one possible explanation; endolytic cleavage at a glutaminyl-glutaminyl bond followed by pyroglutamate formation may contribute to...

journal_title：Medical hypotheses

authors： Saido TC

更新日期：2000-03-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is a severe pulmonary sequela which can affect up to 15% of patients with cirrhotic liver disease. There is no treatment for HPS other than liver transplantation. The cause of HPS is incompletely understood, but the pulmonary vasodilation in HPS is thought to be related to increased leve...

journal_title：Medical hypotheses

authors： Altschuler EL,Kast RE

更新日期：2004-01-01 00:00:00

abstract：:It is generally accepted that a placebo in a standard, randomized, controlled trial (RCT), being an inert substance, cannot itself produce any effects. Yet, the magnitude of the placebo effect has increased remarkably in the last three decades. We propose that macroscopic information entanglement potentially explains ...

journal_title：Medical hypotheses

authors： Manek NJ,Tiller WA

更新日期：2011-10-01 00:00:00

abstract：:The new prion diseases that have emerged in the last 15 years are bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (variant CJD). Although initially confined to the UK, these diseases have recently emerged in other European countries. The accepted cause of the human disease is that BSE spre...

journal_title：Medical hypotheses

authors： Brown DR

更新日期：2001-11-01 00:00:00

abstract：:Previous research from our group suggests that patients with lesions in the left inferior parietal lobule (IPL)-which is concerned with abstract numerical cognition and cross-modal association (which is consistent with its strategic location at the crossroads between the temporal, parietal and occipital lobes) have di...

journal_title：Medical hypotheses

authors： Jalal B,Ramachandran VS

更新日期：2014-06-01 00:00:00

abstract：:A case-control study was conducted in order to test the hypothesis that a reduced exposure to human seminal factors in the early reproductive life of women is a risk factor in breast cancer. The relative risk of exposure to the hypothetical semen-factor deficiency is 4.7 times greater for breast-cancer patients than f...

journal_title：Medical hypotheses

authors： Gjorgov AN

更新日期：1978-03-01 00:00:00

abstract：:Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the ev...

journal_title：Medical hypotheses

authors： Kalapos MP

更新日期：1999-09-01 00:00:00

abstract：:It is well known, that most of the psychiatric diseases affect various neurotransmitter systems. It is the aim of this profile to define a set of cheap analyses, indicative for a specific psychiatric disease, to facilitate differential diagnosis and to offer an additional tool to the already existing clinical-descript...

journal_title：Medical hypotheses

authors： Niederhofer H

更新日期：2011-10-01 00:00:00

abstract：:Reflux of biliary secretions into the pancreatic duct following gallstone obstruction of the common biliary pancreatic ampulla has been implicated as a cause of acute pancreatitis. However, the pancreatic duct pressure is higher than the biliary pressure and, therefore, the simple obstruction of the choledochoduodenal...

journal_title：Medical hypotheses

authors： Arendt T,Mönig H,Stüber E,Katsoulis S,Fölsch UR

更新日期：2000-04-01 00:00:00

abstract：:Tubulointerstitial fibrosis is a final common pathway to the eventual structural desolation of kidneys. However, the mechanism involved in this phenomenon is still poorly understood, and current therapies are ineffective or only marginally effective. Mast cell has a variety of physiological and pathological functions ...

journal_title：Medical hypotheses

authors： Li Y,Liu FY,Peng YM,Li J,Chen J

更新日期：2007-01-01 00:00:00

abstract：:Medicine today is an extremely heterogeneous field of knowledge, based on clinical observations and action knowledge and on data from the biological, behavioral and social sciences. We hypothesize at first that medicine suffers from a disciplinary hyper-diversity compared to the level of conceptual interdisciplinary i...

journal_title：Medical hypotheses

authors： Tretter F,Löffler-Stastka H

更新日期：2019-12-01 00:00:00

abstract：:Intrauterine Contraceptive Devices with multifaceted application potential is a need of an hour. Although, copper-based IUDs exert an effective contraceptive as well as anticancer effects in a long-term basis, but also results in multiple complications. In this regard, RISUG® a polymer based contraceptive device has b...

journal_title：Medical hypotheses

authors： Subramanian B,Agarwal T,Basak P,Maiti TK,Guha SK

更新日期：2019-03-01 00:00:00