The possible role of sodium-potassium adenosine triphosphatase in preterm labour.

abstract：:The authors sought to establish whether maternal dietary methanol during pregnancy was a factor in the etiology of autism spectrum disorders. A seven item questionnaire was given to women who had given birth to at least one child after 1984. The subjects were solicited from a large primary care practice and several in...

journal_title：Medical hypotheses

authors： Walton RG,Monte WC

更新日期：2015-10-01 00:00:00

abstract：:In a recent paper it was argued that all stem cells are small motile cells, the haemopoietic stem cell being no exception. Although haemopoietic stem cells arise and mature in an extravascular milieu, they are present in small numbers in the peripheral circulation, where they have a lymphocyte-like appearance, and in ...

journal_title：Medical hypotheses

authors： Drummond R

更新日期：1994-09-01 00:00:00

abstract：:Genome imprinting has an essential role in normal embryonal mammalian development. Starting early in differentiation, the transcripts of certain human genes, e.g. the paternally-H19 and the maternally-imprinted IGF2, are expressed in specific tissues and organs during fetal life. In several malignant disorders, imprin...

journal_title：Medical hypotheses

authors： Biran H,Ariel I,De Groot N,Hochberg A

更新日期：1994-08-01 00:00:00

abstract：:A comparison of more important physical, chemical and biological properties of the nitric oxide (NO) and free stable nitroxyl radicals (nitroxides) on the base of their structural similarity is made in the article. The active moiety in the nitroxide molecule represents a sterically hindered nitric oxide. The mechanism...

journal_title：Medical hypotheses

authors： Raikov ZD,Raikova ET,Atanasov AT

更新日期：2001-09-01 00:00:00

abstract：:Lack of vascularization results in increased demand for oxygen and creates a defined feature of the tumor microenvironment known as tumor hypoxia. It is well established that in response to hypoxia, hypoxia-inducible factor-1 α (HIF-1α) is induced which is an important factor in angiogenesis, invasion and metastasis. ...

journal_title：Medical hypotheses

authors： Farhadi P,Yarani R,Kiani S,Mansouri K

更新日期：2021-01-01 00:00:00

abstract：:Incretin hormones have trophic effects on beta cell function that can aid prevention and treatment of diabetes. cAMP is the primary mediator of these effects, and has been shown to potentiate glucose-stimulated insulin secretion, promote proper beta cells differentiation by increasing expression of the crucial transcr...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2006-01-01 00:00:00

abstract：:The classical form of Barlow's disease or infantile scurvy, with bruises, broken bones and sores that will not heal, is rarely seen today, but it seems to be reappearing under a different guise, when infants with borderline vitamin C depletion are assaulted with too many inoculations at one time.Moreover, it is now so...

journal_title：Medical hypotheses

authors： Clemetson CA

更新日期：2002-07-01 00:00:00

abstract：:The malignant cell, in vivo, metabolizes and respires anaerobically. For a good many years scientists have been aware of anaerobia being present in malignant growths. The prevailing opinion is that the malignant cell is able to remain viable in an anaerobic medium. This assumption is incorrect and is actually misleadi...

journal_title：Medical hypotheses

authors： White MW

更新日期：1992-12-01 00:00:00

abstract：:Celiac disease is an immune mediated disorder, the only one with a well-established origin, resulting from a permanent gluten intolerance. Although a gluten-free diet is currently the "safe" and appropriate therapy for celiac disease, this is not always an easy and simple option as "harmful" gluten may contaminate foo...

journal_title：Medical hypotheses

authors： Ivanovski PI,Ivanovski IP,Sedlarevic R

更新日期：2007-01-01 00:00:00

abstract：:Neurofibromatosis 1 is a common heritable disorder. The gene causing neurofibromatosis 1 had been recognized and the protein encoded by this gene, neurofibromin, was supposed to play a role in development of various tissues. Neurofibromin was found to have GTP-ase (GAP) domain against small p21 ras. IQGAP1 is another ...

journal_title：Medical hypotheses

authors： Abdel-Wanis ME,Kawahara N

更新日期：2001-03-01 00:00:00

abstract：:Acute carbon monoxide (CO) poisoning causes the neurologic symptoms and brain lesions during both acute and delayed phase. We propose that catecholamine crises in globus pallidus and deep white matter are the key pathophysiological factors causing acute and delayed brain injuries respectively. Increased sympathetic ac...

journal_title：Medical hypotheses

authors： Park EJ,Min YG,Kim GW,Cho JP,Maeng WJ,Choi SC

更新日期：2014-08-01 00:00:00

abstract：:Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disease with no known cause. There are many clues to suggest an environmental trigger for the disease, including reports of conjugal couples and co-localized employees that developed sALS. On the island of Guam,a very high incidence of sALS occ...

journal_title：Medical hypotheses

authors： Stommel EW,Field NC,Caller TA

更新日期：2013-02-01 00:00:00

abstract：:COVID-19 due to the SARS-CoV-2 infection is a multi-systemic immune syndrome affecting mainly the lungs, oropharyngeal region, and other vascular endothelial beds. There are tremendous ongoing efforts for the aim of developing drugs against the COVID-19 syndrome-associated inflammation. However, currently no specific ...

journal_title：Medical hypotheses

authors： Beyazit F,Beyazit Y,Tanoglu A,Haznedaroglu IC

更新日期：2020-10-01 00:00:00

abstract：:Drug biotransformations are controlled in the body by tissue-differentiated choice of a selection of the induced and constitutive 57 isoforms of the human cytochromes P450 (CYP). CYP are the mixed function oxidase enzyme family (EC 1.14.14.1: mono-oxygenases that contain iron-dependent protohaematin IX). Many of the m...

journal_title：Medical hypotheses

authors： Wiseman A

更新日期：2005-01-01 00:00:00

abstract：:In plastic and reconstructive surgery, there is a tremendous clinical need for adequate implants are needed to restore soft-tissue defects resulting from tumor resection, traumatic injury, or congenital anomalies. Restoring the aesthetic function of the soft tissue is as important as restoring the natural tissue funct...

journal_title：Medical hypotheses

authors： Chang Q,Lu F

更新日期：2012-08-01 00:00:00

abstract：:Contralateral central nervous control may be an evolutionary consequence of dependence on the image-forming eye, especially in large organisms. As a result of the topological transformation of the visual stimulus in the pupillary eye, the external environmental hemispace impinges directly upon the contralateral intern...

journal_title：Medical hypotheses

authors： Capozzoli NJ

更新日期：1995-11-01 00:00:00

abstract：:Following the rate of proteoglycan synthesis as the metabolic parameter of the growth of cartilage cells, indicates that hormonal and local agents are two distinct types of extracellular regulators responsible for altering the basic metabolic rates of cells. Such changes in growth rate occur regularly at physiological...

journal_title：Medical hypotheses

authors： Nevo Z,Laron Z

更新日期：1980-04-01 00:00:00

abstract：:With spinal anesthesia the level of surgical analgesia is mostly reported without reference to the neuroanatomic map of spinal nerves. The classical maps are variably and inconsistently reported in many textbooks. Because of the differences between the classical maps of Keegan and Garrett and of Foerster, and also bec...

journal_title：Medical hypotheses

authors： Van Bogaert LJ

更新日期：1997-06-01 00:00:00

abstract：:Intractable epilepsy has always posed a challenge to management; conventional, surgical and alternative techniques available so far (e.g., vagal nerve stimulation, i.e. VNS). The author has attempted to search for a novel alternative (drug-regime) approach to its management to minimise any invasive technique or surger...

journal_title：Medical hypotheses

authors： Jaseja H

更新日期：2003-08-01 00:00:00

abstract：:The high prevalence of deleterious polygenic type 2 diabetes (T2D) is a paradox requiring explanation beyond food excess, inactivity and the obesity resulting from positive energy balance. Historically, hunting-foraging and later agrarian communities often manifested a converse negative energy balance due to nutrition...

journal_title：Medical hypotheses

authors： Wise PH

更新日期：2019-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary tumor of liver and its incidence continues to increase worldwide. HCC is a disease with multifactorial causes and genetic variability has been discussed as a risk factor for its development. Liver is a hormone-sensitive organ and therefore is influenced by gona...

journal_title：Medical hypotheses

authors： Baldissera VD,Alves AF,Almeida S,Porawski M,Giovenardi M

更新日期：2016-01-01 00:00:00

abstract：:The 2013 American Heart Association Blood Cholesterol Guidelines increased the number of patients recommended for statin therapy in the United States to 56million. Two common statin side effects are muscle pain, referred to as "statin-associated muscle symptoms", and increased risk for new onset type-2-diabetes mellit...

journal_title：Medical hypotheses

authors： Carris NW,Tipparaju SM,Magness DJ,Chapalamadugu KC,Magness RR

更新日期：2017-09-01 00:00:00

abstract：:The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 mil...

journal_title：Medical hypotheses

authors： Lim D,Flicker L,Dharamarajan A,Martins RN

更新日期：2003-06-01 00:00:00

abstract：:Erectile dysfunction after nerve injury is a common disease after radical prostatectomy. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which plays an important role in the survival of existing neurons, the differentiation of new neurons, and synaptic plasticity. It has been demonstra...

journal_title：Medical hypotheses

authors： Chiang PK,Yang FY

更新日期：2019-01-01 00:00:00

abstract：:Diabetes mellitus, a metabolic disorder with significant global health care burden, causes chronic microvascular and macrovascular complications that still comprise a therapeutic challenge. Angiotensin-(1-7), a heptapeptide with vasodilatory properties, has been found to restore vascular reactivity and endothelial cel...

journal_title：Medical hypotheses

authors： Kibel A

更新日期：2016-08-01 00:00:00

abstract：:Genetic linkage studies and genome wide analysis have provided insights into complex medical diseases. Mycobacterium avium ss. paratuberculosis (MAP) causes Johne's disease, an important enteric inflammatory disease mostly studied in ruminant animals. MAP is also the putative cause of Crohn's disease. Moreover, MAP ha...

journal_title：Medical hypotheses

authors： Dow CT

更新日期：2014-12-01 00:00:00

abstract：:It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered compositi...

journal_title：Medical hypotheses

authors： Beaugerie L,Langholz E,Nyboe-Andersen N,Pigneur B,Sokol H,ECCO Epicom.

更新日期：2018-06-01 00:00:00

abstract：:Parkinson disease (PD) is a chronic progressive degenerative disorder that affects over 6 million people worldwide. It is manifested by motor and psychiatric signs. The latter inflicts up to 88% of PD patients. With the prolongation of life expectancy, it is presumed that the prevalence of PD will further rise, togeth...

journal_title：Medical hypotheses

authors： Raskin S,Durst R

更新日期：2010-12-01 00:00:00

abstract：:The modern living standard has imposed upon society a situation of chronic sleep deprivation. This chronic loss of sleep affects women more than it does men. As a result, the postponement of pregnancy has become a common choice due to the priority given to social and domestic activities. For women, pregnancy represent...

journal_title：Medical hypotheses

authors： Pires GN,Andersen ML,Giovenardi M,Tufik S

更新日期：2010-12-01 00:00:00

abstract：:Chloroquine is one of the antimalaria drugs, also used to treat rheumatoid arthritis and systemic lupus erythematosus (SLE). Although well tolerated in most individuals, it was suggested that chloroquine can exert a profound influence on renal function, especially in individuals with compromised body fluid status. How...

journal_title：Medical hypotheses

authors： Ahmed MH,Osman MM

更新日期：2007-01-01 00:00:00