Abstract：
:Celiac disease is an immune mediated disorder, the only one with a well-established origin, resulting from a permanent gluten intolerance. Although a gluten-free diet is currently the "safe" and appropriate therapy for celiac disease, this is not always an easy and simple option as "harmful" gluten may contaminate food during the processing and preparation phases. There are also further social pressures, which might be more pressing for young celiac patients, in following a strict gluten-free diet. Therefore, a new therapeutic approaches are sought which would permit celiacs to "peacefully" coexist with gluten. Presently, the most promising looks search for genetically modified wheat lacking toxic gluten peptides and the use of oral endopeptidases in attempt to curb gluten toxicity. Recently discovered role of anti-tissue transglutaminase antibodies in celiac pathogenesis has brought a prospect for a new hypothetical therapeutic approach, an oral immunization of celiacs with xenogeneic anti-tissue transglutaminase antibodies.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Ivanovski PI,Ivanovski IP,Sedlarevic Rdoi
10.1016/j.mehy.2007.04.003subject
Has Abstractpub_date
2007-01-01 00:00:00pages
1257-60issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(07)00279-4journal_volume
69pub_type
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