Abstract：
:Prostate cancer incidence increases with age; along with many other cancers, it could be considered a disease of aging. Prostate cancer screening has led to a significant proportion of men diagnosed with low-grade, low-stage prostate cancer who are now more likely to choose an active surveillance strategy rather than definitive treatments. Definitive treatment, such as surgery and radiation therapy, is useful for high-grade disease; however, because of the low long-term risk of progression of a low-grade disease and side effects of surgery and radiation, these treatments are less commonly used for low-grade disease. While five alpha reductase inhibitors have been shown to reduce the risk of cancer detection on subsequent biopsies for men on active surveillance, no medications have been proven to prevent progression to high-grade disease. mTOR pathways have long been known to influence prostate cancer and are targets in various prostate cancer patient populations. Low-dose mTOR inhibition with rapamycin has shown promise in pre-clinical models of prostate cancer and appear to affect cellular senescence and immunomodulation in the aging population. We hypothesize that low-dose mTOR inhibition could reduce progression of low-grade prostate cancer patients, allowing them to remain on active surveillance.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Liss MA,Rickborn L,DiGiovanni J,Bacich D,DeGraffenried LA,Parihar M,Thompson IM,Sharp ZDdoi
10.1016/j.mehy.2018.06.004subject
Has Abstractpub_date
2018-08-01 00:00:00pages
63-68eissn
0306-9877issn
1532-2777pii
S0306-9877(18)30122-1journal_volume
117pub_type
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journal_title：Medical hypotheses
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pub_type： 杂志文章,评审
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