Endometriosis is sustained by tumour necrosis factor-alpha.

abstract：:Some recent studies have reported a strong link between obesity and attention-deficit/hyperactivity disorder (ADHD). However, to date, the factors underlying this newly described comorbidity are still unclear and unexplored. In the present article, we proposed that the dopamine system and implicate dopamine genes cont...

journal_title：Medical hypotheses

authors： Liu LL,Li BM,Yang J,Wang YW

更新日期：2008-01-01 00:00:00

abstract：:Since forced unilateral nostril breathing activates the contralateral brain hemisphere, an animal analogue of this technique could be provided by methylmethacrylate gluing large plastic pellets in either the right or left nostrils in a group of rats. A large number of physiological, pharmacological, and immunological ...

journal_title：Medical hypotheses

authors： Backon J

更新日期：1989-03-01 00:00:00

abstract：:This paper outlines a method of demonstrating hepatitis B virus (HBV)-related transcriptional activity based on the random amplification of cDNA ends (RACE) protocol. Following RNA extraction from the appropriate tissue, cDNA is synthesized using a long oligo d(T) based primer containing unique 5' oligonucleotide sequ...

journal_title：Medical hypotheses

authors： Sallie R

更新日期：1995-08-01 00:00:00

abstract：:Micelle is a stable, passively targetable and solubilizing minute particle, and plays a key role to anticancer drug delivery for chemotherapy. With an increasing number of novel polymeric micelles synthesized, many anticancer drugs have been core-encapsulated in the micelles. However, only single drug was studied as t...

journal_title：Medical hypotheses

authors： Liu P,Wang B,Weili Qiao JL

更新日期：2008-09-01 00:00:00

abstract：:Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that o...

journal_title：Medical hypotheses

authors： Hobgood DK

更新日期：2011-08-01 00:00:00

abstract：:The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousn...

journal_title：Medical hypotheses

authors： Tonello L,Cocchi M,Gabrielli F,Tuszynski JA

更新日期：2017-04-01 00:00:00

abstract：:Oral water irrigation devices (WIDs) are widely used for oral physiotherapy in homes and dental clinics throughout the world. A major area of concern in the use of WIDs has been the possibility of injury to the sulcular epithelium and underlying tissue. There are several documented clinical cases of tissue injury with...

journal_title：Medical hypotheses

authors： Reddy NP,Kesavan SK

更新日期：1985-12-01 00:00:00

abstract：:In this communication I propose a technique for manipulating the idiotype anti-idiotype network with the aim of enhancing the immune response to tumors. The theoretical basis for this technique follows from Jerne's network theory of the immune system. By tolerizing the host to immunoglobulin bearing idiotypes directed...

journal_title：Medical hypotheses

authors： Sharpe RJ

更新日期：1985-11-01 00:00:00

abstract：:A birth involving shoulder dystocia can rapidly deteriorate-from a fetus with a reassuring tracing in the minutes before birth, to a neonate needing aggressive resuscitation. Infants experiencing a traumatic birth involving shoulder dystocia may be severely compromised, even when the preceding labor was uncomplicated....

journal_title：Medical hypotheses

authors： Mercer J,Erickson-Owens D,Skovgaard R

更新日期：2009-04-01 00:00:00

abstract：:Preliminary but increasing evidence suggests that attention-deficit/hyperactivity disorder (ADHD), Tourette's syndrome (TS), and restless legs syndrome (RLS) may be comorbid. In the present article, we hypothesize that ADHD, TS, and RLS may be part of a spectrum, and that iron deficiency contributes to the pathophysio...

journal_title：Medical hypotheses

authors： Cortese S,Lecendreux M,Bernardina BD,Mouren MC,Sbarbati A,Konofal E

更新日期：2008-01-01 00:00:00

abstract：:It has been uncovered that expansion of trinucleotide repeats in the human genome are causing a variety of genetic diseases. They are also identified in other loci that are not clearly related to particular diseases, which indicates such repeat expansion is one of the general forms of evolution occurring throughout th...

journal_title：Medical hypotheses

authors： Kubota S

更新日期：2001-03-01 00:00:00

abstract：:Down-regulation of hormonal effects is in the presented simulation related to the number of functional receptors and quantity of available hormonal stimulation. The former is in the model substituted with the quantity of stimulation able to produce a full down-regulation (Hs100) of target cells. The halftime (t1/2) of...

journal_title：Medical hypotheses

authors： Kurbel S,Kurbel B,Dicić M,Ugraji V

更新日期：1996-03-01 00:00:00

abstract：:Limbic associated pelvic pain is a proposed pathophysiology designed to explain features commonly encountered in patients with chronic pelvic pain, including the presence of multiple pain diagnoses, the frequency of previous abuse, the minimal or discordant pathologic changes of the involved organs, the paradoxical ef...

journal_title：Medical hypotheses

authors： Fenton BW

更新日期：2007-01-01 00:00:00

abstract：:Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesi...

journal_title：Medical hypotheses

authors： Ma S,Lu Q,Hu H,Du XJ

更新日期：2020-11-01 00:00:00

abstract：:An immune modulation complex is proposed which recognizes and is driven by an MHC presented epitope of the CD4 molecule present on the surface of up regulated CD4+ lymphocytes. Immune modulation is affected by both CD4 lymphocyte destruction and impairment of their potential for immune recognition. These two processes...

journal_title：Medical hypotheses

authors： Kennedy JR

更新日期：1993-11-01 00:00:00

abstract：:The adaptive value of sleep remains unknown in spite of the intense research performed throughout the last decades. However, few sleep researchers are aware of the difficulties posed by the blind acceptance of an extreme adaptationist viewpoint. Under this philosophy, every anatomical and functional detail present in ...

journal_title：Medical hypotheses

authors： Gamundí A,Akaârir M,Coenen AM,Esteban S,Rial RV,Nicolau MC

更新日期：2005-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppr...

journal_title：Medical hypotheses

authors： Damar U,Gersner R,Johnstone JT,Schachter S,Rotenberg A

更新日期：2017-02-01 00:00:00

abstract：:Recent articles about the roles and relationships of tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta 1 in various types of normal tissues and malignancies give rise to the question: 'Is there a relationship between them with regard to malignant melanoma progression?' In the light of many re...

journal_title：Medical hypotheses

authors： Kurdoglu M,Güllü IH,Akalin I

更新日期：2001-08-01 00:00:00

abstract：:A steady fall in mortality rates from cardiovascular diseases (CVD) has been reported recently in the United States. This study tests the hypothesis that fruits and vegetables had a protective effect against cardiovascular mortality among the American population from 1964-78. Special attention was focused on more spec...

journal_title：Medical hypotheses

authors： Verlangieri AJ,Kapeghian JC,el-Dean S,Bush M

更新日期：1985-01-01 00:00:00

abstract：:Recent findings demonstrate the vital role of endothelial progenitor cells in the homeostasis of the vessel wall and the development of atherosclerosis. Endothelial progenitor cells (EPCs) play important roles in repair-to-injury of arteries. Many evidences have shown Cardiovascular risk factors closely correlated wit...

journal_title：Medical hypotheses

authors： Zhang M,Zhou SH,Li XP,Shen XQ,Fang ZF

更新日期：2008-01-01 00:00:00

abstract：:Exercise-induced hypoalgesia is characterised by a reduction in pain sensitivity following exercise. Recently, low intensity exercise performed with blood flow restriction has been shown to induce hypoalgesia. The purpose of this manuscript is to discuss the mechanisms of exercise-induced hypoalgesia and provide ratio...

journal_title：Medical hypotheses

authors： Hughes L,Patterson SD

更新日期：2019-11-01 00:00:00

abstract：:Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndr...

journal_title：Medical hypotheses

authors： Williams AC,Ramsden DB

更新日期：2007-01-01 00:00:00

abstract：:Interleukin (IL)-1, an established mediator of inflammation, is also a mediator of ovulation (a cyclic inflammatory-like process). We have shown that IL-1 beta induces the in vitro expression of genes believed to play important role in ovulation (IL-1 beta itself, its receptors, IL-1 beta receptor antagonist, glucose ...

journal_title：Medical hypotheses

authors： Kol S,Kehat I,Adashi EY

更新日期：2002-01-01 00:00:00

abstract：:Anorexia nervosa manifests a wide range of features which cannot fully be explained on the basis of socio-cultural pressures to be thin, nor by starvation, nor dehydration. Evidence is emerging of a significant neurobiological contribution to its aetiology. However there has to date been no explanation for its pathoge...

journal_title：Medical hypotheses

authors： Nunn K,Frampton I,Lask B

更新日期：2012-05-01 00:00:00

abstract：:The three events, viz. schizophrenia, dissociative anaesthesia and Near-Death Experience, despite their seemingly unrelated manifestation to each other, have nevertheless similar functional basis. All three events are linked to the glutamate sensitive N-methyl-D-aspartate (NMDA) receptor complex, which serves as their...

journal_title：Medical hypotheses

authors： Bonta IL

更新日期：2004-01-01 00:00:00

abstract：:To discuss the possible pathogenesis of outlet obstructive constipation (OOC) and identify the theoretical basis of the Procedure for Prolapse and Hemorrhoids (PPH) used to treat outlet obstructive constipation (OOC). 19 patients diagnosed with outlet obstructive constipation (OOC) form the case group, and 9 healthy v...

journal_title：Medical hypotheses

authors： Qin Z,Pang L,Dai W,Yan W,Zhang J,Zhao Y,Li Q,Wu K,Zhou B

更新日期：2015-07-01 00:00:00

abstract：:Knowledge about how information is stored in neurons of animals and in the human brain is still incomplete. A hypothesis related to long-term changes in synaptic efficiency has strong experimental support, but does not seem to be able to explain all observations. It has recently been proposed that magnetite together w...

journal_title：Medical hypotheses

authors： Alfsen EM,Størmer FC,Njå A,Walløe L

更新日期：2018-10-01 00:00:00

abstract：:The paradigm of an immune system presumes that a system arose specifically to combat infection -- hence its name. This paradigm gained credibility with the discovery of antibodies and anamnestic immunity, even though these are relatively late arrivals in evolution. Another presumption has been that thymus-dependent T ...

journal_title：Medical hypotheses

authors： Cunliffe J

更新日期：1999-03-01 00:00:00

abstract：:Interleukin (IL)-17 is a pro-inflammatory cytokine originally described in T lymphocytes. Increased production of IL-17 has been linked to the induction of cytokines, chemokines and adhesion molecules in various cell types, effects that likely contribute to a number of inflammatory diseases including rheumatoid arthri...

journal_title：Medical hypotheses

authors： Csiszar A,Ungvari Z

更新日期：2004-01-01 00:00:00

abstract：:In light of the progressive, pubertal increases in serum gonadotropin (FSH, LH) levels coinciding with the peak incidence of simple goiters; the common alpha subunits associated with the gonadotropins, TSH and hCG; the ability of LH and hCG to bind to thyroid TSH receptors and affect thyroid function; and, the probabl...

journal_title：Medical hypotheses

authors： DiNicola AF

更新日期：1983-04-01 00:00:00