Detection of hepatitis B virus transcriptional activity: an hypothesis.

abstract：:Obesity is a major risk-factor for the development of insulin resistance, type 2 diabetes, and cardiovascular disease. Circulating molecules associated with obesity, such as saturated fatty acids and cholesterol crystals, stimulate the innate immune system to incite a chronic inflammatory state. Studies in mouse model...

journal_title：Medical hypotheses

authors： Demidowich AP,Davis AI,Dedhia N,Yanovski JA

更新日期：2016-07-01 00:00:00

abstract：:Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large numbe...

journal_title：Medical hypotheses

authors： Huang Y,Liu A,Liu L,Wang B,Liang G

更新日期：2020-02-01 00:00:00

abstract：:The inverse association between maternal folate status and incidence of infants born with neural tube defects (NTD's) was recognized over twenty years ago and led the US health agencies in the early 1990s to recommend that women of childbearing age consume 400 microg of folic acid each day. The FDA followed by mandati...

journal_title：Medical hypotheses

authors： Rogers EJ

更新日期：2008-09-01 00:00:00

abstract：:Dementia and other causes of functional disability can create considerable burdens for families and society as a whole, but it may be possible to partially alleviate this strain through technical innovations that replace some functions of human caregivers. This article proposes the hypothesis that cell phones, interne...

journal_title：Medical hypotheses

authors： Alisky JM

更新日期：2006-01-01 00:00:00

abstract：:Temporomandibular joint (TMJ) ankylosis is a disease that severely affects the human health. Although it is well known that trauma is the most common cause of TMJ ankylosis, the mechanisms by which the traumatic TMJ ankylosis develops are unclear. The existing hypothesis is not convincing in explaining the genesis of ...

journal_title：Medical hypotheses

authors： Meng FW,Zhao JL,Hu KJ,Liu YP

更新日期：2009-07-01 00:00:00

abstract：:The disturbances of the 11p15.5 chromosomal region are associated with Beckwith-Wiedemann syndrome, Russell-Silver syndrome, Wilms tumor, IMAGe syndrome, and idiopathic hemihyperplasia. The aim of this research was to examine the hypothesis that 11p15.5 initially became unstable in the European population about 200 ye...

journal_title：Medical hypotheses

authors： Shterenshis M,Roitblat Y,Ilani J,Lumbroso J,Padilla-Raygoza N

更新日期：2018-12-01 00:00:00

abstract：:Although fibrosis and emphysema are in many ways on opposite ends of the pulmonary parenchymal disease spectrum, they seem to share common pathomechanistic steps. This is illustrated by the coexistence of both entities in lungs of individuals with combined pulmonary fibrosis and emphysema. Macroproteins elastin and co...

journal_title：Medical hypotheses

authors： Janssen R,de Brouwer B,von der Thüsen JH,Wouters EFM

更新日期：2018-11-01 00:00:00

abstract：:The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...

journal_title：Medical hypotheses

authors： Larijani B,Ghahari A,Warnock GL,Aghayan HR,Goodarzi P,Falahzadeh K,Arjmand B

更新日期：2015-06-01 00:00:00

abstract：:Melasma is an acquired disorder of pigmentation that presents with asymptomatic symmetric darkening of the face. The pathogenesis of this condition is multifactorial and influenced by several factors including female sex hormones, genetic predisposition and ultraviolet light exposure. The management of melasma is usua...

journal_title：Medical hypotheses

authors： Cohen PR

更新日期：2017-04-01 00:00:00

abstract：:Dysbiosis is a prominent feature of inflammatory bowel diseases (IBD). However, the efficacy of using antibiotics aiming at the aberrant gut microflora for IBD treatment are either unsuccessful or not persistent. In contrast, long-term oral vancomycin has been proved effective in controlling both the bile duct and gut...

journal_title：Medical hypotheses

authors： Du W,Han W,Dong J

更新日期：2020-11-01 00:00:00

abstract：:Colic is generally defined as excessive crying in early infancy and can have negative consequences on the infant as well as on the infant's family life. Excessive crying can result in escalating parental stress levels, abusive caregiver response, increased risk of shaken baby syndrome and parental postpartum depressio...

journal_title：Medical hypotheses

authors： Jordan GJ

更新日期：2014-09-01 00:00:00

abstract：:Inotropic treatment remains the cornerstone for cardiogenic shock, an emergency that requires immediate resuscitative therapy before shock irreversibly damages vital organs. Although the sympathomimetic drug dobutamine is the most widely-used inotropic drug worldwide, it has several side effects including sinus tachyc...

journal_title：Medical hypotheses

authors： Roubille F,Lattuca B,Busseuil D,Leclercq F,Davy JM,Rhéaume E,Tardif JC

更新日期：2013-08-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, with increasing incidence and prevalence in the last one-half century. IBD patients suffer from autonomic vagal neuropathy and nerve dysfunction, with deficiency of acetylcholine in inflamed mucosa. Recent studies showed that death of enteric neuron ...

journal_title：Medical hypotheses

authors： Guo Y,Lu N,Bai A

更新日期：2012-11-01 00:00:00

abstract：:The cumulative incidence of uterine leiomyoma at age 50 is ≈ 70% in White women and >80% in Black women. Although risk factor research is limited, increasing age, and being premenopausal, nulliparous or Black are risk factors for leiomyomas. Black women tend to have larger leiomyomas and be younger at diagnosis. Surpr...

journal_title：Medical hypotheses

authors： Wegienka G

更新日期：2012-08-01 00:00:00

abstract：:There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compare...

journal_title：Medical hypotheses

authors： Dahlen HG,Kennedy HP,Anderson CM,Bell AF,Clark A,Foureur M,Ohm JE,Shearman AM,Taylor JY,Wright ML,Downe S

更新日期：2013-05-01 00:00:00

abstract：:The activity of the lithium ion against DNA type viruses is explained by its competition with magnesium ions. Magnesium acts as the cofactor of the enzymes responsible for the replicative building of viral proteins and nucleosides. When lithium replaces magnesium, it appears to render the polymerase enzymes impotent. ...

journal_title：Medical hypotheses

authors： Bach RO

更新日期：1987-06-01 00:00:00

abstract：:Hypertension is the leading cause of cardiovascular diseases, and an estimated 972 million people in the world are suffering from this problem. Indubitably, hypertension is an important worldwide public-health challenge. In recent years many efforts have been made to devise novel therapies involving new targets implic...

journal_title：Medical hypotheses

authors： Li YF,Xiao CS,Hui RT

更新日期：2009-09-01 00:00:00

abstract：:Neuroleptic-induced tardive dyskinesia represents a major serious side-effect of chronic therapy with neuroleptic drugs. The pathomechanisms underlying this disorder are not well understood. Although the dopaminergic supersensitivity theory has gained most attention, there is evidence to suggest involvement of other t...

journal_title：Medical hypotheses

authors： Sandyk R

更新日期：1986-01-01 00:00:00

abstract：:Recent articles about the roles and relationships of tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta 1 in various types of normal tissues and malignancies give rise to the question: 'Is there a relationship between them with regard to malignant melanoma progression?' In the light of many re...

journal_title：Medical hypotheses

authors： Kurdoglu M,Güllü IH,Akalin I

更新日期：2001-08-01 00:00:00

abstract：:Curvilinear distraction is currently under investigation to reconstruct curved maxillofacial bone defects. However, previous studies have revealed the discrepancy between the contour of the regenerated bone in the distraction gap and the curvilinear pathway of the transport disc. We hypothesize that the discrepancy is...

journal_title：Medical hypotheses

authors： Zhou L,Shang H,Feng Z,Liu C,Ye W,Ma Q,Wu W,Liu Y

更新日期：2012-10-01 00:00:00

abstract：:The aim was to search for periodical fluctuations in daily occurrence of gout attacks during the synodic lunar cycle. 126 gout attacks were recorded between 1972 and 1994 at known calendar dates. The synodic plexogram, displaying the number of attacks for each day of the cycle, was processed by cosinor regression. A p...

journal_title：Medical hypotheses

authors： Mikulecký M,Rovenský J

更新日期：2000-07-01 00:00:00

abstract：:S-allylgutimine has immunostimulant and tumor cell inhibitory activities. This complex action may be a result of the stimulation of IL-2 production. The effectiveness of immunotherapy depends on the uncoupling of IL-2 downregulation. This principle can be widely used with those immunological diseases where IL-2 level ...

journal_title：Medical hypotheses

authors： Vértesi C

更新日期：1993-06-01 00:00:00

abstract：:Posttraumatic stress disorder (PTSD) is a severe anxiety disorder that develops after exposure to trauma. Symptoms include persistent reexperiencing, persistent avoidance, persistent numbing, and persistent hyperarousal. Subsequent to trauma exposure, the onset of symptoms of an acute stress reaction can typically dev...

journal_title：Medical hypotheses

authors： Wallace J

更新日期：2013-06-01 00:00:00

abstract：:MS risk is associated with low vitamin D status prior to disease, and Epstein Barr virus (EBV) infection seems to be a prerequisite for MS. EBV could activate autoreactive T cells by several mechanisms, but it is not clear why this leads to MS. Only a small proportion of those infected with EBV develops MS, whereas au...

journal_title：Medical hypotheses

authors： Holmøy T

更新日期：2008-01-01 00:00:00

abstract：:Several experiments show that there is a cell to cell communication by light in different cell types. This article describes theoretical mechanisms and subcellular structures that could be involved in this phenomenon. Special consideration is given to the nervous system, since it would have excellent conditions for su...

journal_title：Medical hypotheses

authors： Grass F,Klima H,Kasper S

更新日期：2004-01-01 00:00:00

abstract：:Concerning the damage to back muscles and posterior ligament complex (PLC) by posterior open approach for lumbar spinal stenosis (LSS), the oblique lateral intervertebral fusion (OLIF) is pretty popular nowadays. However, oblique lateral approach has obvious drawbacks, which are limited vision and operative scope for ...

journal_title：Medical hypotheses

authors： Du C,Wu T,Mao T,Jia F,Hai B,Zhu B,Liu X

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Migraine is a highly prevalent, disabling, and costly disorder worldwide. From a long time ago, headaches have been known to be associated with gastrointestinal (GI) disorders. Headaches originating from gastric complaints were appreciated by Persian Medicine (PM) scholars. Today, functional GI disorders are...

journal_title：Medical hypotheses

authors： Talafi Noghani M,Namdar H

更新日期：2019-04-01 00:00:00

abstract：:Hypotheses regarding the factors that predispose individuals to developing AIDS after exposure to HTLV-III/LAV are beginning to emerge. It is suggested here that surgical removal of tonsils in childhood may increase the risk of developing opportunistic infections after infection with this newly discovered retrovirus. ...

journal_title：Medical hypotheses

authors： McCombie SC

更新日期：1986-03-01 00:00:00

abstract：:Exosomes are small vesicles that are released by almost every cell type and play a crucial role in many physiological and pathological processes associated with different diseases. Specifically, they promote angiogenesis in the pathogenesis of some diseases. According to previous research, the proteins of exosomes tak...

journal_title：Medical hypotheses

authors： Tong Y,Zhou YL,Wang YX,Zhao PQ,Wang ZY

更新日期：2016-12-01 00:00:00

abstract：:The exact aetiology of mitral valve prolapse (MVP) is unknown, although this is the most common cardiac valvular abnormality currently detected. MVP has high incidence in young individuals, particularly during the second and third decades. These individuals are usually of a slender body habitus indicating higher rates...

journal_title：Medical hypotheses

authors： Kumar PD

更新日期：2000-02-01 00:00:00