Abstract：
:Hypertension is the leading cause of cardiovascular diseases, and an estimated 972 million people in the world are suffering from this problem. Indubitably, hypertension is an important worldwide public-health challenge. In recent years many efforts have been made to devise novel therapies involving new targets implicated in cardiovascular diseases. Hydrogen sulfide (H(2)S) is a member of a growing family of "gasotransmitters". It is clear that H(2)S plays a pivotal role in the basal regulation of vessels tone. Also studies demonstrate that intravenous sodium hydrosulfide (NaHS), a donor of H(2)S, dose-dependently decreases systolic blood pressure. However, because of its active chemical property, NaHS can be easily oxidized, even spontaneously ignited in the open air. Moreover, its solution is not stable. So the pharmacal use of NaHS is limited by its properties. Calcium sulfide (CaS), one of the effective components in a traditional herb, is another donor of H(2)S. It has more stable chemical properties than NaHS. We hypotheses that CaS might be given by mouth as a new antihypertensive drug through certain dosage form designing. To test this hypothesis, we should establish animal models for studies including drug efficacy, drug safety, drug toxicology, drug metabolism and drug kinetics.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Li YF,Xiao CS,Hui RTdoi
10.1016/j.mehy.2009.03.030subject
Has Abstractpub_date
2009-09-01 00:00:00pages
445-7issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(09)00221-7journal_volume
73pub_type
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
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pub_type： 杂志文章
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更新日期：1982-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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更新日期：2010-02-01 00:00:00
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更新日期：2017-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.10.029
更新日期：2016-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.02.038
更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90239-2
更新日期：1995-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90517-0
更新日期：1995-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0306-9877(92)90161-5
更新日期：1992-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.10.018
更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(82)90012-3
更新日期：1982-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(95)90266-x
更新日期：1995-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1089
更新日期：2000-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.06.011
更新日期：2012-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.03.025
更新日期：2011-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.08.029
更新日期：2009-03-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.07.021
更新日期：2013-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 临床试验,杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2020-02-21 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.08.047
更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90010-4
更新日期：1981-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90249-2
更新日期：1996-03-01 00:00:00
abstract：:The mechanisms of fibroproliferation disease (FPD) of the skin, such as keloids and hypertrophic scars, are still unknown. Since mechanical stress appears to be an important factor for FPD generation, we have studied the intervening factors that connect mechanical stress with keloid and scar formation. Hence, we intro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.01.032
更新日期：2008-01-01 00:00:00
