Retinal pigment epithelium cell-derived exosomes: Possible relevance to CNV in wet-age related macular degeneration.

abstract：:This hypothesis would help to elevate safety in nanogold-therapy of some cancers. It has no previous record in published media and there is no existing protocol for what is expressed in this paper. The hypothesis makes some experimental recommendations for future research at the interface of nanotechnology and biologi...

journal_title：Medical hypotheses

authors： Bonjar LS

更新日期：2013-05-01 00:00:00

abstract：:In the AKR strain of mice a high incidence of spontaneous lymphoid leukemia develops before 12 months of age. Genetic, viral, and endocrine factors interact during development to produce the syndrome. Many of the deficiencies of AKR mice are associated with gene action in chromosome 17, at or near the major histocompa...

journal_title：Medical hypotheses

authors： Vriend J

更新日期：1976-11-01 00:00:00

abstract：:Space adaptation syndrome (SAS) incapacitates about 50% of the astronauts with symptoms of headache, malaise, vomiting, vertigo, etc. A hypothesis that SAS is caused by elevated intracranial pressure secondary to the cephalad fluid shift in zero G is proposed. A mechanism of how the cephalad fluid shift could cause el...

journal_title：Medical hypotheses

authors： Jennings T

更新日期：1990-08-01 00:00:00

abstract：:Pseudohypoaldosteronism Type I may occur due to several different causes. The authors recommend distinguishing between effector and receptor disorders with regard to the diverse mode of inheritance and prognosis. ...

journal_title：Medical hypotheses

authors： Bayer M,Kutílek S

更新日期：1993-09-01 00:00:00

abstract：:Studies have reported an increasing incidence of thyroid cancer worldwide. The reasons are likely related to improved imaging modalities, altered histopathologic criteria for diagnosis of thyroid cancer, and nuclear exposure. However, the classical assumption derived from epidemiological studies is that it should be q...

journal_title：Medical hypotheses

authors： Gursoy A

更新日期：2010-01-01 00:00:00

abstract：:Hypotheses generally conform to paradigms which, over time, change, usually tardily, after they have become increasingly difficult to sustain under the impact of non-conforming evidence and alternative hypotheses, but more important, when they no longer are comfortably ensconced in the surrounding social-economic-poli...

journal_title：Medical hypotheses

authors： Kaellis E

更新日期：2006-01-01 00:00:00

abstract：:For almost 70 years, essential fatty acid deficiency has been known to be associated with skin disorders, vessel abnormalities, and increased tumorigenesis. However, the underlying molecular and cellular mechanism is largely unknown. Recently, it has been reported that essential fatty acids regulate cell adhesion by m...

journal_title：Medical hypotheses

authors： Jiang WG,Eynard AR,Mansel RE

更新日期：2000-09-01 00:00:00

abstract：:It is proposed that gastrin promotes the uptake of divalent and trivalent metal ions from the gastrointestinal lumen by catalyzing the binding of metal ions to luminal albumin and transferrin respectively. The following observations are consistent with this hypothesis: 1. Gastrin binds both divalent and trivalent meta...

journal_title：Medical hypotheses

authors： Baldwin GS

更新日期：1992-05-01 00:00:00

abstract：:Mandibular asymmetry (MA) is one of the most common craniofacial malformations. However, there is no optimal technique for this malformation nowadays. A novel technique for both children and adults with less disadvantages is a must. Parathyroid hormone (PTH) is a straight-chain polypeptide secreted by the parathyroid ...

journal_title：Medical hypotheses

authors： Wan Q,Li ZB

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Short-term acute care public county hospitals in the US were a mainstay of much "safety net" medical care in the early twentieth century. The private sector currently provides much of what was in the past public medical care. Does this transition affect health care indices? METHODS:The presence of public ho...

journal_title：Medical hypotheses

authors： Shandera WX

更新日期：2019-11-01 00:00:00

abstract：:The hypterphosphorylation of tau proteins is a well-established step in the expression of the pathological features in Alzheimer's disease (AD). While a primary event that links aluminum and AD, the so-called 'aluminum hypotheses', is far from being demonstrated, however, the metal ion could be an important etiologica...

journal_title：Medical hypotheses

authors： Zatta PF

更新日期：1995-03-01 00:00:00

abstract：:The few existing hypotheses for the function of the human hymen are weak. These are briefly reviewed, and a new hypothesis is proposed. We suggest that the appearance of the juvenile human hymen is based on 'premature' birth, following which infant helplessness and a subsequent advantage for vaginal protection from ex...

journal_title：Medical hypotheses

authors： Hobday AJ,Haury L,Dayton PK

更新日期：1997-08-01 00:00:00

abstract：:The hepatitis B infection leads to various profound pathological processes in liver metabolism. Some biochemical alterations detectable by blood analysis are currently used for a preliminary evaluation of the infection. Based on existing data we present here evidence that non-protein amino acid L-homoserine is a patho...

journal_title：Medical hypotheses

authors： Gazarian KG,Gening LV,Gazarian TG

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Geldanamycin, which is one of the most potent and effective hsp90 alpha inhibitor until date, is normally used to target breast cancer. Inhibition of hsp90 alpha leads to the degradation of client proteins involved in the initiation and progress of breast cancer pathogenesis. Hence, Geldanamycin has been wid...

journal_title：Medical hypotheses

authors： Mahanta S,Pilla S,Paul S

更新日期：2013-09-01 00:00:00

abstract：:In a survey based on the biographical sketches, obituary notes and eulogies of notable scientists, eight were identified as belonging to an elite group, having authored more than 1000 research publications, which include books, monographs and patents. They were, in chronological order, Thomas Alva Edison, Paul Karrer,...

journal_title：Medical hypotheses

authors： Kantha SS

更新日期：1992-10-01 00:00:00

abstract：:Corona virus disease 2019 (Covid-19), a pandemia emerged recently, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). The receptor for corona virus and influenza A is the mucosal cell membrane protein angiotensin converting enzyme 2 (ACE2), which is abundant on the membrane of alveolar cells and ...

journal_title：Medical hypotheses

authors： Niv Y

更新日期：2020-10-01 00:00:00

abstract：:Periodontal disease is a chronic multifactorial infectious and inflammatory disease associated with several chronic systemic diseases, such as diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease, hypertension, Alzheimer's disease and so on. These same systemic diseases have been associated w...

journal_title：Medical hypotheses

authors： Räisänen IT,Umeizudike KA,Pärnänen P,Heikkilä P,Tervahartiala T,Nwhator SO,Grigoriadis A,Sakellari D,Sorsa T

更新日期：2020-11-01 00:00:00

abstract：:For many years there was a general belief that the enzyme renin, having been secreted into the circulation by the kidney in response to appropriate stimuli, initially generates the inactive decapeptide angiotensin I in the bloodstream. This is then converted to the biologically active octapeptide angiotensin II by ang...

journal_title：Medical hypotheses

authors： Duckworth AJ,Goodship AE,Kendall HJ,Osborn EC

更新日期：2001-04-01 00:00:00

abstract：:Nitrosamines have been identified in vaginal secretions of women with trichomoniasis. Both nitrites and amines the elements for nitrosamine synthesis are produced by the abnormal-predominantly anaerobic-vaginal flora of patients with bacterial vaginosis/trichomoniasis. The final formation of nitrosamines could also de...

journal_title：Medical hypotheses

authors： Pavić N

更新日期：1984-12-01 00:00:00

abstract：:A general theory of neural circuitry is proposed wherein neural impulses travel in a continuous circuit from the brain to the extremities and back to the brain. At the extremities the impulse may be modified by the environment there. At the spinal column the return signal is compared with the outgoing signal and the a...

journal_title：Medical hypotheses

authors： Kingham DJ

更新日期：1994-05-01 00:00:00

abstract：:Neandertals were an anatomically distinct hominoid species inhabiting a vast geographical area ranging from Portugal to western Siberia and from northern Europe to the Middle East. The species became extinct 28,000 years ago, coinciding with the arrival of anatomically modern humans (AMHs) in Europe 40,000 years ago. ...

journal_title：Medical hypotheses

authors： Wolff H,Greenwood AD

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Huachansu, a Chinese medicine that comes from dried toad venom from the skin glands of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, has been used in treatment of cancers. We conducted a meta-analysis to evaluate the efficacy and safety of Huachansu combined with chemotherapy for advanced gas...

journal_title：Medical hypotheses

authors： Xie X,Huang X,Li J,Lv X,Huang J,Tang S,Sun Y

更新日期：2013-08-01 00:00:00

abstract：:Many studies have focused on the detrimental effects of malnourishment to the performance of the brain and peripheral nerves. Undernourished children and adults have been studied extensively to establish these consequences. Little attention has been given to the body habitus that affects optimum neurological performan...

journal_title：Medical hypotheses

authors： Grantham J,Henneberg M

更新日期：2014-11-01 00:00:00

abstract：:Neurodegenerative diseases are associated with neuronal inclusions, comprised of protein aggregates. In Alzheimer's Disease (AD) and Lewy Body Disease (LBD) such lesions are distributed in a hierarchical retrograde transynaptic spatial pattern. This implies a retrograde transynaptic temporal propagation as well. There...

journal_title：Medical hypotheses

authors： Royall DR

更新日期：2013-02-01 00:00:00

abstract：:Glaucoma is the leading cause of irreversible blindness worldwide, which is now viewed as a disease of brain with pathogenesis not fully understood. The main diagnostic methods are examining the retinal nerve fiber layer through optical coherence tomography and investigating visual field defect, but these methods pres...

journal_title：Medical hypotheses

authors： Sun Y,Huang W,Li F,Li H,Wang L,Huang Y,Zhang X

更新日期：2019-02-01 00:00:00

abstract：:Bipedal locomotion and fine motility of hand and larynx of humans introduced musculoskeletal adaptations, new pyramidal, corticostriatal, corticobulbar, nigrostriatal, and cerebellar pathways and expansions of prefrontal, cingular, parieto-temporal and occipital cortices with derived new brain capabilities. All select...

journal_title：Medical hypotheses

authors： Ghika J

更新日期：2008-11-01 00:00:00

abstract：:Preliminary reports have demonstrated that anterior nucleus thalamus high-frequency electrical stimulation (ANT-HFS) is an effective treatment for patients who suffer from medically refractory epilepsy. However, its extensive application has been hampered by the high cost and the unpredictable outcome before the opera...

journal_title：Medical hypotheses

authors： Yan N,Chen N,Lu J,Wang Y,Wang W

更新日期：2013-09-01 00:00:00

abstract：:Schizophrenia, if not the most difficult, is one of the most difficult mysterious puzzles for psychiatrists, psychologists, and neuroscientists to solve. In this paper, based on the previously known pathologies of schizophrenia, a new model is proposed for explanation of the formation of positive psychotic symptoms of...

journal_title：Medical hypotheses

authors： Javanbakht A

更新日期：2006-01-01 00:00:00

abstract：UNLABELLED:One plausible explanation for the controversy that surrounds the causes and clinical management of obesity is the notion that overeating and obesity may only be a couple of "symptoms" associated with a yet to be discovered medical disorder. OBJECTIVES:To introduce the Salted Food Addition Hypothesis. This t...

journal_title：Medical hypotheses

authors： Cocores JA,Gold MS

更新日期：2009-12-01 00:00:00

abstract：:The S-oxidation of S-carboxymethyl-l-cysteine has been reported previously to be a biomarker of disease susceptibility in Parkinson's disease and Amyotrophic lateral sclerosis. In this investigation, the original observations have been confirmed with the incidence of the poor metaboliser phenotype (no urinary recovery...

journal_title：Medical hypotheses

authors： Steventon GB,Mitchell SC

更新日期：2018-09-01 00:00:00