Abstract：
:In a survey based on the biographical sketches, obituary notes and eulogies of notable scientists, eight were identified as belonging to an elite group, having authored more than 1000 research publications, which include books, monographs and patents. They were, in chronological order, Thomas Alva Edison, Paul Karrer, Margaret Mead, Giulio Natta, Hans Selye, Herbert C Brown, Tetsuji Kametani and Carl Djerassi. Among these, Karrer, Natta and Brown were Nobelists in chemistry. Four criteria which can be identified as clues to their prolific productivity are, 1) enthusiasm for compulsive work and eccentric life style, 2) physical and/or environmental handicap, 3) pioneering efforts in a new research field, and 4) selection of research area, predominantly organic chemistry.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Kantha SSdoi
10.1016/0306-9877(92)90179-gkeywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
159-63issue
2eissn
0306-9877issn
1532-2777pii
0306-9877(92)90179-Gjournal_volume
39pub_type
历史文章,杂志文章abstract：:Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin:light therapy is hypothesized to be mediated by superoxide. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90116-x
更新日期：1981-02-01 00:00:00
abstract：:Rushton bodies (RBs) are one of the characteristic features seen in the epithelial lining of odontogenic cysts mainly radicular, dentigerous and odontogenic keratocyst. It has two different histo-morphological appearances; granular and homogeneous. Although widely investigated, the exact pathogenesis and histogenesis ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.06.007
更新日期：2016-08-01 00:00:00
abstract：:Hemolysis-associated pulmonary hypertension (HA-PH) is a serious clinical complication of various hemolytic disorders, and pulmonary hypertension (PH) is considered the greatest risk factor for death in patients with a hemolytic disorder. It is now well established that hemolysis causes the release of soluble hemoglob...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.12.043
更新日期：2009-06-01 00:00:00
abstract：:It has been hypothesized that sulfite oxidase deficient persons may be at increased risk to toxicity from SO2 and dietary sulfites widely used for food preservation. Sulfite oxidase is believed to be responsible for the detoxification of SO2 and/or sulfite to sulfate for excretion. Human and animal studies have shown ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(81)90110-9
更新日期：1981-02-01 00:00:00
abstract：:Recently, the concept of drug delivery requires that the release of encapsulated drug be produced only at the diseased site with controllable rates. Given that thermosensitive hydrogels have been widely investigated for controlled delivery based on their phase transition, we speculate that nanoparticles with the novel...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.03.023
更新日期：2008-08-01 00:00:00
abstract：:In both African AIDS populations and homosexual populations outside of Africa, a high incidence of syphilis and multiple exposures to infectious diseases results in frequent, often abusive use of antibiotics. Epidemiological evidence exists for chemical immunosuppression resulting from antibiotics and other prescribed...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90036-8
更新日期：1986-12-01 00:00:00
abstract：UNLABELLED:One plausible explanation for the controversy that surrounds the causes and clinical management of obesity is the notion that overeating and obesity may only be a couple of "symptoms" associated with a yet to be discovered medical disorder. OBJECTIVES:To introduce the Salted Food Addition Hypothesis. This t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.06.049
更新日期：2009-12-01 00:00:00
abstract：:With spinal anesthesia the level of surgical analgesia is mostly reported without reference to the neuroanatomic map of spinal nerves. The classical maps are variably and inconsistently reported in many textbooks. Because of the differences between the classical maps of Keegan and Garrett and of Foerster, and also bec...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90116-x
更新日期：1997-06-01 00:00:00
abstract：:In endemic pemphigus foliaceus (EPF) or "fogo selvagem" the epidemiological evidence shows that all the described outbreaks occur on the banks of rivers where there is mercury contamination from alluvium gold mining and deforestation. Pathophysiological evidence shows a similarity to pemphigus induced by sulphydryl (S...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.09.041
更新日期：2012-01-01 00:00:00
abstract：:Howard Gardner identified five different kinds of creative activity among eminent creators, namely, solving a well-defined problem, putting forth a general conceptual scheme, creating a product that embodies ideas, stylized innovation of an art form, and a 'high-stakes' performance in the socio-political arena. In thi...
journal_title：Medical hypotheses
pub_type： 传,历史文章,杂志文章
doi：10.1054/mehy.1998.0777
更新日期：1999-10-01 00:00:00
abstract：:Superficial fraying, splitting and fibrillation of articular cartilage as a consequence of ageing or mechanical injury is not always associated with joint pain. However, similar cartilage lesions accompanied by synovitis and engorgement of the subchondral vasculature generally is; the disorder being known as osteoarth...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90068-2
更新日期：1993-08-01 00:00:00
abstract：:A new hypothesis concerning the association of low levels of steroid hormones and hypercholesterolemia is proposed. This study presents data that concurrent restoration to youthful levels of multiple normally found steroid hormones is able to normalize or improve serum total cholesterol (TC). We evaluated 20 patients ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00324-9
更新日期：2002-12-01 00:00:00
abstract：:It is suggested that apart from aflatoxins, plant medicinal preparations containing active compounds imperatorin, dictamine, marmesin and heraclenin may be responsible for some human cancers in Nigeria and perhaps other parts of Africa. Therefore, in this paper, a hypothesis is put forward that these compounds or thei...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(83)90096-8
更新日期：1983-07-01 00:00:00
abstract：:Recently, a theory has been postulated that suggests that vital enzymes in ingested food interact synergistically with enzymes within the human body and more specifically with enzymes in the digestive tract. Alterations in food enzymes induced by bulk processing including heating and irradiation and also the addition ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90152-x
更新日期：1994-06-01 00:00:00
abstract：:The prevailing view of lung cancer is multi-step progression of normal cells into cancer cells through gain of function oncogenes coupled with loss of tumor suppressor genes. This progression of genetic damage ultimately results in the hallmarks of cancer. This theory has strong support from studies finding genetic da...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.12.050
更新日期：2006-01-01 00:00:00
abstract：:Through the analysis of accumulated experimental data of cell growth, a model of unrestricted cell growth is presented here. This model is based hypothetically on the cellular commitment to senescence as in the previously presented commitment theory. Cells are divided into 3 types, namely uncommitted cells, committed ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90034-a
更新日期：1992-08-01 00:00:00
abstract：:Rett syndrome (RTT) is an X-linked dominant postnatal severe and disabling neurodevelopmental disorder which is the second most common cause for genetic mental retardation in girls and the first pervasive disorder with a known genetic basis. The syndrome is primarily caused by mutations in the Methyl CpG binding prote...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.09.015
更新日期：2011-02-01 00:00:00
abstract：:The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 mil...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00072-0
更新日期：2003-06-01 00:00:00
abstract：:Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large numbe...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2019.109448
更新日期：2020-02-01 00:00:00
abstract：:Incretin hormones have trophic effects on beta cell function that can aid prevention and treatment of diabetes. cAMP is the primary mediator of these effects, and has been shown to potentiate glucose-stimulated insulin secretion, promote proper beta cells differentiation by increasing expression of the crucial transcr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.04.031
更新日期：2006-01-01 00:00:00
abstract：:The hepatitis B infection leads to various profound pathological processes in liver metabolism. Some biochemical alterations detectable by blood analysis are currently used for a preliminary evaluation of the infection. Based on existing data we present here evidence that non-protein amino acid L-homoserine is a patho...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1527
更新日期：2002-04-01 00:00:00
abstract：:September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Pop...
journal_title：Medical hypotheses
pub_type： 传,社论,历史文章
doi：10.1016/j.mehy.2009.09.021
更新日期：2009-12-01 00:00:00
abstract：:Chlorination of potable water supplies high in organics may yield carcinogenic compounds such as trihalomethanes. Chlorine dioxide has been proposed as an alternative disinfectant to chlorine. However, chlorine dioxide is a strong oxidant that forms significant amounts of chlorite when added to potable water supplies,...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(78)90017-8
更新日期：1978-09-01 00:00:00
abstract：:It has been suggested that dopamine may play an important role in human evolution and adaptive behaviors. Recent studies have revealed an association between the dopamine system and social support among healthy individuals. However, the underlying mechanism remains unclear. In the present study, we propose a dopamine ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.07.030
更新日期：2011-11-01 00:00:00
abstract：:Supercritical carbon dioxide (CO(2)) possesses germicide (bactericide and sporicide) effect. Despite of the fact, that this effect is used in industrial sterilization processes, the sterilization mechanism at molecular level is unclear. Our hypotheses can provide a molecular-biological explanation for the phenomenon. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.08.043
更新日期：2010-02-01 00:00:00
abstract：:Behcet's disease (BD) is a chronic, multisystem inflammatory disorder characterized by relapsing oral aphthous and genital ulcers, ocular inflammation, erythemanodosum and folliculitis-like lesions of the skin, arthritis, and central nervous system involvement. Its pathogenesis has not been fully elucidated but the et...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.01.046
更新日期：2009-07-01 00:00:00
abstract：:In the present report we have developed a mathematical model to describe the processes involved during high steroid therapy. We have shown that the model can predict clinical observations as well as determine the optimum steroid regimen without relying on trial and error methods. The model incorporates rate processes ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1308
更新日期：2001-07-01 00:00:00
abstract：:This article proposes a series of experiments to determine if cows and sheep could be used as animal models for HIV-1, the AIDS virus. To justify this effort, a substantial case is presented that HIV-1 is a natural recombinant of Bovine Leukemia Virus (BLV) and Visna Virus. This natural recombinant may have been inadv...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(93)90069-3
更新日期：1993-10-01 00:00:00
abstract：:Intrinsic radio-sensitivity is the determinant of differential response of tumours to low LET ionising radiations. The probabilistic DNA fibril both model shows intrinsic radio-sensitivity factor [I] as function of nuclear diameter (Nd) and intra cellular hydrogen ion concentration [H+]. Linking probabilities of letha...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.09.031
更新日期：2013-12-01 00:00:00
abstract：:Both, hamstring and ACL injuries are among the most typical injuries, particularly in change of direction and high speed running sports. They're also difficult to treat. Therefore, in the past few years, sports medicine practitioners and exercise scientists have mainly been focusing on the development and implementati...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.10.002
更新日期：2017-11-01 00:00:00
