Abstract：
:The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 million dollars annually. There is currently no cure for AD but various therapeutic agents have been employed in attempting to slow down the progression of the illness, one of which is oestrogen. Over the last decades, scientists have focused mainly on the roles of oestrogen in the prevention and treatment of AD. Newer evidences suggested that testosterone might also be involved in the pathogenesis of AD. Although the exact mechanisms on how androgen might affect AD are still largely unknown, it is known that testosterone can act directly via androgen receptor-dependent mechanisms or indirectly by converting to oestrogen to exert this effect. Clinical trials need to be conducted to ascertain the putative role of androgen replacement in Alzheimer's disease.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Lim D,Flicker L,Dharamarajan A,Martins RNdoi
10.1016/s0306-9877(03)00072-0keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
893-6issue
6eissn
0306-9877issn
1532-2777pii
S0306987703000720journal_volume
60pub_type
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