The possible role of tropical medicinal preparations in human carcinoma in Africa.

abstract：:Diabetic individuals frequently suffer from skin pathologies, especially in their feet. Co-existing peripheral vascular disease and neuropathy exacerbate the capacity of these individuals to cope with infections, minor cuts and wounds, often leading to hard to treat and chronic ulcers. Copper has potent anti-fungal an...

journal_title：Medical hypotheses

authors： Borkow G,Zatcoff RC,Gabbay J

更新日期：2009-12-01 00:00:00

abstract：:Interventions focusing on the prevention and treatment of chronic non-communicable diseases are on rise. In the current article, we propose that dysfunction of the mesocortico-limbic reward system contributes to the emergence of the WHO-identified risk behaviors (tobacco use, unhealthy diet, physical inactivity and ha...

journal_title：Medical hypotheses

authors： Zsuga J,Tajti G,Papp C,Juhasz B,Gesztelyi R

更新日期：2016-05-01 00:00:00

abstract：:Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe), manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium (Ca) - have been observed in the foodchains that traditionally support the Chamorro populations affected by high incidence clusters of Alzheimer (AD), Parkinson-like ...

journal_title：Medical hypotheses

authors： Purdey M

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...

journal_title：Medical hypotheses

authors： Shahabi S,Hassan ZM,Jazani NH,Ebtekar M

更新日期：2006-01-01 00:00:00

abstract：:This hypothesized reflex relates the vertical direction of gaze to the amount of tension exerted by the ciliary muscle. Based on simple observations the following is assumed. When looking downwards a tendency for closer focusing (near searching) exists even without a specific visual stimulus, whereas looking up favors...

journal_title：Medical hypotheses

authors： Blumenthal EZ

更新日期：1991-12-01 00:00:00

abstract：:A case-control study was conducted in order to test the hypothesis that a reduced exposure to human seminal factors in the early reproductive life of women is a risk factor in breast cancer. The relative risk of exposure to the hypothetical semen-factor deficiency is 4.7 times greater for breast-cancer patients than f...

journal_title：Medical hypotheses

authors： Gjorgov AN

更新日期：1978-03-01 00:00:00

abstract：:Hyperemesis gravidarum (HG) is the most severe form of illness within the spectrum of nausea and vomiting of pregnancy. Liver disease, usually consisting of mild serum transaminase elevation, occurs in almost 50% of patients with HG. While multiple risk factors have been proposed, the etiology and underlying mechanism...

journal_title：Medical hypotheses

authors： Outlaw WM,Ibdah JA

更新日期：2005-01-01 00:00:00

abstract：:Angiogenesis and the acquisition of an angiogenic phenotype is important for cancer cell proliferation. Copper in an essential trace element that participates in many enzymatic complexes like the cytochrome c, superoxide dismutase and lysyl oxidase and it is involved in processes, like embryogenesis, growth, angiogene...

journal_title：Medical hypotheses

authors： Antoniades V,Sioga A,Dietrich EM,Meditskou S,Ekonomou L,Antoniades K

更新日期：2013-12-01 00:00:00

abstract：:Mood disturbances and depression are supposed to have a negative impact on patients' outcome in malignant tumour disease. On the other hand, poor prognosis in cancer patients is associated with chronic immune challenge which is paralleled by enhanced degradation of the essential amino acid tryptophan and thus decrease...

journal_title：Medical hypotheses

authors： Murr C,Widner B,Sperner-Unterweger B,Ledochowski M,Schubert C,Fuchs D

更新日期：2000-08-01 00:00:00

abstract：:Lysosomes, lysosomal enzymes and oxidant processes are known to be involved in cancer processes. The prostasomes contain proteins and enzymes that would constitute pathways for the hydrolysis of proteins and peptides. However, integrated biochemical and cell biology studies are necessary to understand how lysosomal en...

journal_title：Medical hypotheses

authors： Tappel A

更新日期：2005-01-01 00:00:00

abstract：:Prostate cancer incidence increases with age; along with many other cancers, it could be considered a disease of aging. Prostate cancer screening has led to a significant proportion of men diagnosed with low-grade, low-stage prostate cancer who are now more likely to choose an active surveillance strategy rather than ...

journal_title：Medical hypotheses

authors： Liss MA,Rickborn L,DiGiovanni J,Bacich D,DeGraffenried LA,Parihar M,Thompson IM,Sharp ZD

更新日期：2018-08-01 00:00:00

abstract：:Solutes concentration in the aqueous humor of the eye is highest near the ciliary processes in the posterior chamber (p.c.) and lowest near the trabecular meshwork in the anterior chamber (a.c.). The high osmotic gradient across the semipermeable iris causes it to easily move forward at this location and occasionally ...

journal_title：Medical hypotheses

authors： Mark HH

更新日期：2003-03-01 00:00:00

abstract：:Many brilliant and ambitious young women lose their drive for top careers after childbirth. New maternal impulses are at odds with their original ambitions and for many mothers stress and frustration will be the result as they have to combine child care with workweeks of 60-80h to reach or remain at the top. Pregnancy...

journal_title：Medical hypotheses

authors： Schulpen TWJ

更新日期：2017-09-01 00:00:00

abstract：UNLABELLED:The expression of consciousness and the site of memory storage within the brain are unknown despite over a century of intense empirical scrutiny. Recent anatomical studies show that human protoplasmic astrocytes form innumerable uniform polyhedral tessellating domains that are arranged three-dimensionally. T...

journal_title：Medical hypotheses

authors： Robertson JM

更新日期：2013-12-01 00:00:00

abstract：:Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism, altering the inflammatory and metabolic signals contributing substantially to the development of hepatic IR. Current therapies for t...

journal_title：Medical hypotheses

authors： Deng J,Wang M,Guo Y,Fischer H,Yu X,Kem D,Li H

更新日期：2020-03-14 00:00:00

abstract：:Despite important advances in understanding its pathophysiology, therapy for septic shock remains largely symptomatic and supportive. Aiming to elevate the systemic arterial blood pressure by using vasoconstrictor manoeuvers are preferred without paying much attention to the ischaemia produced at the peripheral tissue...

journal_title：Medical hypotheses

authors： Iskit AB,Guc MO

更新日期：2004-01-01 00:00:00

abstract：:Geographic patterns with diminishing rates from north to south toward the equator have been described for a number of diseases, putatively related largely to "western" lifestyle. Among these the inflammatory bowel diseases; Crohn's (CD) and Ulcerative colitis (UC) have been prominent in sharing distributions with a nu...

journal_title：Medical hypotheses

authors： Szilagyi A,Xue X

更新日期：2016-11-01 00:00:00

abstract：:This paper compares two models of the sense of smell and demonstrates that the new model has advantages over the accepted model with implications for medical research. The accepted transduction model had an odourant or pheromone contacting an aqueous sensory lymph then movement through it to a receptor membrane beneat...

journal_title：Medical hypotheses

authors： Nicholson B

更新日期：2001-09-01 00:00:00

abstract：:It is well known, that most of the psychiatric diseases affect various neurotransmitter systems. It is the aim of this profile to define a set of cheap analyses, indicative for a specific psychiatric disease, to facilitate differential diagnosis and to offer an additional tool to the already existing clinical-descript...

journal_title：Medical hypotheses

authors： Niederhofer H

更新日期：2011-10-01 00:00:00

abstract：:Rheumatic heart disease (RHD) remains a major cause of cardiac related mortality and morbidity in the developing countries due to poor diagnosis and lack of proper therapeutics. The definite reason of heart valve injury during RHD is poorly understood. Valvular endothelial cells play an important role in pathogenesis ...

journal_title：Medical hypotheses

authors： Sarkar S,Chopra S,Rohit MK,Banerjee D,Chakraborti A

更新日期：2016-10-01 00:00:00

abstract：:Natural objects, live and inanimate, actively maintain their entities by using their capacities (i.e., properties, internal resources, mechanisms, and experience) adequately to their needs. It is suggested that the principle of adequate function is a law of nature. ...

journal_title：Medical hypotheses

authors： Yabrov A

更新日期：1986-03-01 00:00:00

abstract：:Numerous medical conditions present with acute and severe autonomic and muscular overactivity. These syndromes include Neuroleptic Malignant Syndrome, Serotonin Syndrome, Dysautonomia (or paroxysmal sympathetic storms) following acquired brain injury, Autonomic Dysreflexia, Parkinsonian-Hyperpyrexia Syndrome, Malignan...

journal_title：Medical hypotheses

authors： Baguley IJ

更新日期：2008-01-01 00:00:00

abstract：:Virulence factors are microbial products that are known to be harmful to the host and may assist in the pathogenesis of the micro-organism. Superantigens, including those produced by bacteria and viruses, clearly act as virulence factors. The clinical effects of superantigens can be not only acute but also chronic and...

journal_title：Medical hypotheses

authors： Soos JM,Schiffenbauer J,Torres BA,Johnson HM

更新日期：1997-03-01 00:00:00

abstract：:The "Gamma Loop" Part I compared a model of rubber tubing to the architecture of the glomerulus with emphasis placed on the observed relationship between the position of the outflow resistance clamp and the perfusion of the loop (1, 2). Part II describes the pressures observed in the different parts of the loop, as we...

journal_title：Medical hypotheses

authors： Gatzek WJ,Wells SC

更新日期：1989-05-01 00:00:00

abstract：:Dysbiosis is a prominent feature of inflammatory bowel diseases (IBD). However, the efficacy of using antibiotics aiming at the aberrant gut microflora for IBD treatment are either unsuccessful or not persistent. In contrast, long-term oral vancomycin has been proved effective in controlling both the bile duct and gut...

journal_title：Medical hypotheses

authors： Du W,Han W,Dong J

更新日期：2020-11-01 00:00:00

abstract：:The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with oth...

journal_title：Medical hypotheses

authors： Amano S,Yamagishi S,Koda Y,Tsuneoka M,Soejima M,Okamoto T,Inagaki Y,Yamada K,Kimura H

更新日期：2003-04-01 00:00:00

abstract：:Genome imprinting has an essential role in normal embryonal mammalian development. Starting early in differentiation, the transcripts of certain human genes, e.g. the paternally-H19 and the maternally-imprinted IGF2, are expressed in specific tissues and organs during fetal life. In several malignant disorders, imprin...

journal_title：Medical hypotheses

authors： Biran H,Ariel I,De Groot N,Hochberg A

更新日期：1994-08-01 00:00:00

abstract：:Neuromyelitis optica (NMO) is an uncommon, life-threatening demyelinating disease that produces transverse myelitis and optic neuritis. An important pathogenetic mechanism belongs to NMO-IgG autoantibodies directed against the ultrastructure of the water channel aquaporin-4 (AQP4), the so-called orthogonal arrays of p...

journal_title：Medical hypotheses

authors： Warth A

更新日期：2009-09-01 00:00:00

abstract：:Randomized clinical trials comparing neoadjuvant chemotherapy (NAC) followed by surgery with initial surgery in cervical cancer reported conflicting results. We provided a hypothesis explaining the different outcomes between trials. NAC was reported to make a lymph node metastasis smaller. Smaller tumors are hard to d...

journal_title：Medical hypotheses

authors： Kim K,Kim MJ,Chung HH,Choi SC,Ryu SY,Kim JW,Park NH,Song YS,Kang SB

更新日期：2009-12-01 00:00:00

abstract：:Cerebral ischemia is still one of the most confusing and enigmatic neurological disorders with least understood injuries. The EEG measures have been traditionally used to detect residual neural dysfunctions after cerebral ischemia although having several shortcomings, yielding controversial and inconsistent results. I...

journal_title：Medical hypotheses

authors： Bhattacharya P,Pandey AK,Paul S,Patnaik R

更新日期：2013-09-01 00:00:00